A kind of natamycin polymer micelle eye drop and preparation method thereof

Abstract

The invention relates to a natamycin polymer micelle eye drop and a preparation method thereof, belonging to the technical field of ophthalmic disease treatment. In order to solve the problem that the frequency of administration of the existing natamycin eye drops is too high, the invention provides a kind of natamycin polymer micelles eye drops, comprising a certain mass volume ratio of the natamycin polymer micelles and phosphate buffer saline, wherein the mass percentage of natamycin in the natamycin polymer micelle is 10 to 30%, and the balance is polyethylene glycol polyglycerol methacrylate block copolymer . In the present invention, polyethylene glycol-polyglycerol methacrylate block copolymer is placed in ethanol to self-assemble cross-linked micelles, and the natamycin polymer micelles eye drops obtained after encapsulating natamycin can Prolong the release time of natamycin, reduce the frequency of medication, and solve the problem of poor patient compliance caused by high-frequency medication. It has excellent properties such as high drug loading, slow release, safety and non-toxicity, and low-frequency eye drops can cure fungal cornea. inflammation.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic disease treatment, and in particular relates to a natamycin polymer micelle eye drop and a preparation method thereof. Background technique [0002] Fungal keratitis is an infectious corneal disease caused by pathogenic fungi with a high rate of blindness. If the diagnosis and treatment are not timely, not only visual impairment, but also serious eye complications such as corneal perforation and endophthalmitis will occur. Natamycin eye drops are the only eye drops approved by the US Food and Drug Safety Administration (FDA) for the control of fungal keratitis, and have the advantages of broad antibacterial spectrum and few adverse reactions. However, the frequency of administration of natamycin eye drops is relatively high: once every 1-2 hours at the beginning, after 3-4 days, change to 6-8 times a day for about 14-21 days. Such a high frequency of medication leads to poor patient complianc...

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that the frequency of administration of the existing natamycin eye drops is too high, the invention provides a kind of natamycin polymer micellar eye drops and a preparation method thereof

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