Application of gypsogenic acid to preparation of analgesics

A technology of caryophyllic acid and drugs, which is applied in the field of preparation of analgesic drugs, can solve problems such as unsatisfactory analgesic effects, and achieve good analgesic activity, simple preparation and operation procedures, and easy-to-obtain effects

Pending Publication Date: 2020-01-14
YUNNAN MINZU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are also analgesic drugs or pharmaceutical compositions made

Method used

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  • Application of gypsogenic acid to preparation of analgesics
  • Application of gypsogenic acid to preparation of analgesics
  • Application of gypsogenic acid to preparation of analgesics

Examples

Experimental program
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preparation example Construction

[0044] The present invention also provides a preparation method of caryophyllic acid, which comprises preparing the compound from a plant of the genus Fusarium (such as Physanthus falciparum). Preferably, caryophyllic acid is prepared from the roots, stems, leaves, and fruits of a plant of the genus Fusarium lentils. Preferably, the method has the steps of:

[0045] (1) extracting with a solvent after drying and pulverizing the lentils, and merging the extract;

[0046] (2) concentrating under reduced pressure the extract in (1) to obtain extractum;

[0047] (3) suspending the extract in (2) in water, extracting with sherwood oil, ethyl acetate and n-butanol successively, and then steaming off the solvent with a rotary evaporator to obtain sherwood oil, ethyl acetate and n-butanol respectively. butanol extract;

[0048] (4) The ethyl acetate extract in (3) was separated by silica gel column chromatography, and 8 components (Fr.1-8 ).

[0049] (5) Purify Fr.2 in (4) by Sep...

Embodiment 1

[0061] Inhibitory activity of lentil extract on acetic acid writhing response in mice

[0062] Source of material: The lentils of the genus False, the lentils of Lijiang and the lentils of southern Yunnan; they were collected in Kunming, Lijiang and Mengzi, respectively, and identified as Dolicostrilobus L., D.appendiculatus by Associate Professor Yang Qingsong, College of Ethnic Medicine, Yunnan University for Nationalities Hand.-Mazz, and D.junghuhnianus Benth. The specimens are preserved in the Herbarium of the School of Medicine for Nationalities, Yunnan University for Nationalities.

[0063] Preparation of the lentil lentil extract: crush the root of the lentil lentil to obtain the root fragments of the lentil lentil; then extract the lentil lentil fragments with 95% ethanol / water reflux for 3 times, each time for 2 hours to obtain the extract ; Filtrate the lentil extract and concentrate it under reduced pressure with a rotary evaporator to obtain an extract for later u...

Embodiment 2

[0071] Further experiments with sickle lentils

[0072] Example 1 was repeated using 95% methanol / water, 70% ethanol / water and 70% acetone / water as extraction solvents respectively. The experimental results show that 95% methanol extract, 70% ethanol extract and 70% acetone obtained by using 95% methanol / water, 70% ethanol / water and 70% acetone / water as extraction solvents respectively The extract of / water also has significant inhibitory activity to the mouse acetic acid writhing reaction, so using different concentrations of ethanol / water, methanol / water or acetone / water as the extraction solvent can also obtain the mouse acetic acid writhing in the sickle lentil Components that inhibit body reactions. The results are shown in Table 2.

[0073] Table 2. Inhibitory effects of different solvent extracts of lentil lentils on the acetic acid writhing response of mice.

[0074]

[0075]

[0076] n=3

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Abstract

The invention provides application of gypsogenic acid to preparation of analgesics, and particularly relates to application of the gypsogenic acid. The gypsogenic acid is used for treating neuralgia,ostalgia, muscle pain, pain caused by traumatic injury, headache, stomach pain, intestinal colic, biliary colic, renal colic and cancer pain. The invention further discloses application of a salt of the gypsogenic acid to the preparation of the analgesics. The gypsogenic acid can be a naturally-occurring organic compound, has relative high analgesic activity, and can be used as an active ingredient together with a pharmaceutically acceptable carrier or auxiliary materials to prepare the analgesics or a pharmaceutical composition.

Description

technical field [0001] The present invention relates to the use of caryophyllic acid and its salts in the preparation of analgesic drugs, in particular to the use of caryophyllic acid and its salts which can be isolated from leguminous plants of the genus Fusarium genus (such as Fusarium lentils) in the preparation of analgesic drugs use. Background technique [0002] As one of the most common clinical symptoms, pain has been listed as the fifth vital sign after respiration, pulse, blood pressure, and body temperature. According to the duration of the disease, pain is divided into acute pain and chronic pain. At present, chronic pain has become one of the main diseases that endanger the health of our people. There are more than 300 million patients with chronic pain in my country, and the number of chronic pain patients is increasing at a rate of 10 million to 20 million every year. What's more serious is that in recent years, the population of pain patients has gradually ...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P29/00
CPCA61K31/56A61P29/00A61K2300/00
Inventor 黄相中杨淬田凯李艳红李育晓逯娅李育逵
Owner YUNNAN MINZU UNIV
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