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Soft x-ray ion source

An ion source and x-ray technology, applied in the field of ionization sources, can solve the problems of dissociation without atomic selectivity, difficulty in directional dissociation of macromolecules, and inability to detect molecular ion peaks, and achieves the ability to enrich fingerprint fragment information, Simplify the tedious sample preparation process and suppress the effect of background chemical noise interference

Inactive Publication Date: 2020-01-17
THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the light sources used in these technical publications are limited to the vacuum ultraviolet wavelength range (100-200nm), and the samples to be tested need to be dissolved in volatile organic solvents to characterize macromolecular chain segments and polypeptides that are not easily soluble and have complex structures. has certain limitations
Although vacuum ultraviolet single-photon dissociation has high efficiency, due to its low energy, it cannot cover the absorption edges of some important atoms. The dissociation is not atom-selective, and it is difficult to dissociate macromolecules in a directional manner.
There is also the use of hydrated protons (H 3 o + ) transfer as an ionization source method Proton transfer reaction source (PTR) The principle of this technology is that the proton affinity energy of most VOCs is higher than that of water but lower than that of high poly water, and can react with protons to be ionized. This method has a simple structure. The molecular ion peak is obvious, which belongs to the relatively excellent soft ionization technology, but there are para-alcohols, aldehydes and long-chain alkanes, and the application of this method will be greatly limited
For example, under normal test conditions, n-butanol cannot detect molecular ion peaks, but can only detect the peak of dehydroxylated butene, which brings great difficulties to the test of n-butanol.
[0005] Among the existing atmospheric pressure ion sources, it is difficult to find an ion source with a general solution. Various ion sources have more or less limitations in the analysis of sample types, mainly due to more or less problems in energy acquisition.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] like figure 1 As shown in the figure: 101, radiation light source; 102, protective device; 103 liquid introduction nozzle; 104, excited high-energy state environment area; 105, opening.

[0039]Among them, it can be understood that the radiation source 101 is used to generate X-rays covering the high-energy region, that is, to excite the high-energy state environment region 104, the opening 105 is the docking position of the ion source structure and the atmospheric pressure interface, and the rear end is connected to the vacuum chamber of the mass spectrometer, specifically including Necessary structures of ion guides, mass analyzers, and ion detectors at all levels; liquid samples enter the cavity from the liquid introduction nozzle 103 through manual injection or a peristaltic pump, and complete ionization, declustering and A series of processes such as desolvation, and the negative pressure environment of the mass spectrometer atmospheric pressure interface through t...

Embodiment 2

[0041] like Figure 2-3 As shown in the figure: 101, radiation light source; 102, protection device; 103 liquid introduction nozzle; 104, excited high energy state environment area; 105, opening; 106 auxiliary structure; 107, vacuum pump; 108, ion concentrator.

[0042] The difference from Embodiment 1 is that in order to improve the performance of the ion source, some supplementary structures are added.

[0043] in, figure 2 In this embodiment, auxiliary structure 106 is added. In this embodiment, auxiliary structure 106 can be a pipeline, which is used to introduce auxiliary sample radiation ionization auxiliary agent into the cavity. What needs to be further explained is that auxiliary agent is methanol, ethanol, water vapor, At least one of hydrogen sulfide, methane, helium, and nitrogen, for example, methanol and water vapor as additives. The function of improving the ionization efficiency or suppressing background chemical noise interference is accomplished. Of course...

Embodiment 3

[0047] like Figure 5 As shown in the figure: 201, radiation light source; 202, protection device; 203, placing platform; 204, excited high-energy state environment area; 205, opening.

[0048] Among them, it can be understood that the radiation source 201 is used to generate X-rays covering the high-energy region, that is, to excite the high-energy state environment region 204, the opening 205 is the docking position between the ion source structure and the atmospheric pressure interface, and the rear end is connected to the vacuum chamber of the mass spectrometer, specifically including Necessary structures such as ion guides, mass analyzers, and ion detectors at all levels; liquid or fixed samples are placed in the sample tank on the placement table 203, and ionization, declustering, and desolvation are completed in the excited high-energy state environment area 204 A series of processes, and enter the mass spectrometer through the negative pressure environment of the mass ...

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Abstract

The invention belongs to the technical field of ionization sources. The invention particularly relates to a soft x-ray ion source. The ion source comprises a radiation light source and a protection device, the radiation light source is installed on the protection device. The protection device is provided with a cavity used for wrapping short-wave radiation generated by the radiation light source.An opening is formed in the protection device; the opening is conducted with the cavity and used for connecting the ion source structure and the atmospheric pressure interface. According to the invention, the short-wave radiation source is adopted, so the ion source is small in size, simple in structure, adjustable in wave band, low in stray light, high in energy and sufficient in sample ionization energy, the problems of desolvation and ion sampling efficiency do not exist, the sensitivity is high, and the result reproducibility is good; the influence of insufficient ionization of a sample, addition of cluster ions and the like caused by an ion inhibition effect on analysis can be effectively solved; a sample which is difficult to ionize can be ionized to obtain a complete ionization product, background interference is reduced, and meanwhile, a specific auxiliary sample radiation ionization aid can be introduced so as to achieve the soft x-ray ion source.

Description

technical field [0001] The invention belongs to the technical field of ionization sources, and in particular relates to a soft X-ray ion source. Background technique [0002] The ion source is the core component of the mass spectrometer. It ionizes the injected neutral substance into ions. It is the first step in the realization of mass spectrometry and plays a very important role in the field of mass spectrometry technology. There are many types of ion sources, mainly including vacuum ionization sources and atmospheric pressure ionization sources. Vacuum ionization sources such as fast atom bombardment ionization source (FAB), electron bombardment ionization source (EI), chemical ionization source (CI), etc., these ionization sources need to work under certain vacuum conditions, while atmospheric pressure ionization sources can The ion source working in the atmospheric environment is more representative of the electrospray ionization source (ESI). As a relatively new ioniz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/10H01J49/26
CPCH01J49/10H01J49/26
Inventor 徐元宏乔金平
Owner THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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