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Sugar-free herba lamiophlomis rotatae oral liquid preparation and preparation method thereof

A unique, oral liquid technology, applied in anti-inflammatory agents, blood diseases, pharmaceutical formulations, etc., can solve the problems of large irritation, uneven size, slow dissolution rate, etc., to save production costs, improve extraction rate, reduce residual effect

Inactive Publication Date: 2020-01-24
TIANJIN PHARMA GROUP XINZHENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products on the market include Duyiwei capsules and Duyiwei tablets, but there are many problems in the above products; the bioavailability is not high; the drug stability is not good; the distribution area in the gastrointestinal tract is small and the irritation is large; Difficult to divide doses or coat; long disintegration time, slow dissolution rate, large dosage and other disadvantages directly affect the quality and curative effect of the drug

Method used

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  • Sugar-free herba lamiophlomis rotatae oral liquid preparation and preparation method thereof
  • Sugar-free herba lamiophlomis rotatae oral liquid preparation and preparation method thereof
  • Sugar-free herba lamiophlomis rotatae oral liquid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method of sugar-free unique oral liquid is as follows:

[0022] Step (1): 0.5 kg is removed blindly, chopped, crushed with a 10-mesh sieve, and set aside.

[0023] Step (2): After heating 15 times the prescription amount of water to about 45°C, put in unique herbs, soak for 2 hours, filter, and save the filtrate, add 12 times the amount of water to the filter residue, soak for two hours, filter, and combine The filtrate is concentrated at a temperature of 65-70°C and a vacuum of 0.06-0.08Mpa to a clear paste with a relative density of 1.10-1.15 at 70°C;

[0024] Step (3): Add ethanol to make the alcohol content reach 60%, stir well, let stand for 24 hours, filter, and recover ethanol from the filtrate to a relative density of 1.20-1.25 (70°C);

[0025] Step (4): Take 30g of xylitol to make 15% simple syrup, 2g of potassium sorbate, stir to dissolve, add water to adjust the total amount to 1000ml, stir well, filter, fill, and sterilize to obtain reddish-...

Embodiment 2

[0027] The preparation method of sugar-free unique oral liquid is as follows:

[0028] (1) Remove impurities blindly for 0.5kg, chop, crush with 10-mesh sieve, and set aside.

[0029] (2) After heating 15 times the prescription amount of water to about 45°C, add the unique medicinal material, soak for 2 hours, filter, and save the filtrate. Add 12 times the amount of water to the filter residue, soak for two hours, filter, and combine the filtrate. Concentrate (temperature 65-70°C, vacuum degree 0.06-0.08Mpa) to a clear paste with a relative density of 1.10-1.15 (70°C).

[0030] (3) Add ethanol to make the alcohol content reach 70%, stir well, let stand for 24 hours, filter, recover ethanol from the filtrate to a relative density of 1.20-1.25 (70°C),

[0031] (4) Take 40g of xylitol to make 20% simple syrup, 2g of potassium sorbate, stir to dissolve, add water to adjust the total amount to 1000ml, stir well, filter, fill, and sterilize to obtain a reddish-brown clear liquid ...

Embodiment 3

[0033] The preparation method of sugar-free unique oral liquid is as follows:

[0034] (1) Remove impurities blindly for 0.5kg, chop, crush with 10-mesh sieve, and set aside.

[0035] (2) After heating 15 times the prescription amount of water to about 45°C, add the unique medicinal material, soak for 2 hours, filter, and save the filtrate. Add 12 times the amount of water to the filter residue, soak for two hours, filter, and combine the filtrate. Concentrate (temperature 65-70°C, vacuum degree 0.06-0.08Mpa) to a clear paste with a relative density of 1.10-1.15 (70°C).

[0036] (3) Add ethanol to make the alcohol content reach 80%, stir well, let it stand for 24 hours, filter, recover ethanol from the filtrate to a relative density of 1.20-1.25 (70°C),

[0037] (4) Take 60g of xylitol to make 30% simple syrup, 2g of potassium sorbate, stir to dissolve, add water to adjust the total amount to 1000ml, stir well, filter, fill, and sterilize to obtain a reddish-brown clear liqui...

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Abstract

The invention discloses a sugar-free herba lamiophlomis rotatae oral liquid preparation, and relates to the field of pharmacy. Every 1000 ml of a herba lamiophlomis rotatae oral liquid comprises 400-600 g of herba lamiophlomis rotatae, 20-40 g of xylitol, 1-2 g of potassium sorbate, and the balance purified water. According to a prescription of the sugar-free herba lamiophlomis rotatae oral liquidpreparation, only xylitol and a small quantity of the preservative are added, thus, the sugar-free herba lamiophlomis rotatae oral liquid preparation is more suitable for being taken by diabetics suffering from post-surgery incision pain and bleeding, traumatic fractures, muscle and bone sprains, rheumatic arthralgia, and symptoms such as metrorrhagia, metrostaxis, dysmenorrhea, gingiva swellingand pain, and bleeding; and the sugar-free herba lamiophlomis rotatae oral liquid preparation has effects of blood circulation promoting, pain alleviating, stasis removing, and hemostasis.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a sugar-free unique oral liquid preparation and a preparation method thereof. Background technique [0002] Duyiwei, the name of traditional Chinese medicine. It is the unique root and rhizome or whole plant of Labiatae. It has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. Indications of traumatic injuries, muscle and bone pain, joint swelling and pain, dysmenorrhea, metrorrhagia. The products on the market include Duyiwei capsules and Duyiwei tablets, but there are many problems in the above products; the bioavailability is not high; the drug stability is not good; the distribution area in the gastrointestinal tract is small and the irritation is large; Difficult to divide dosage or coating; Disadvantages such as long disintegration time, slow dissolution rate, and large dosage directly affect the quality and cu...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/08A61P29/00A61P7/04A61P17/02A61P19/08A61P19/04A61P15/00A61P1/02A61P35/00A61P37/02A61P31/04
CPCA61K9/0095A61K36/53A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/02A61P7/04A61P15/00A61P17/02A61P19/04A61P19/08A61P29/00A61P31/04A61P35/00A61P37/02
Inventor 郭洋静周红建李俊霞白艳鹤
Owner TIANJIN PHARMA GROUP XINZHENG
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