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Biomarkers for Early Detection of Severity and Prognosis Evaluation of Aneurysmal Subarachnoid Hemorrhage and Their Applications

A subarachnoid space, biomarker technology, applied in the field of molecular diagnosis and molecular biology, to improve the effect of diagnosis and treatment

Active Publication Date: 2020-01-31
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, regarding the H in the CSF of aSAH patients and rats 2 The expression of S-generating enzymes has rarely been reported

Method used

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  • Biomarkers for Early Detection of Severity and Prognosis Evaluation of Aneurysmal Subarachnoid Hemorrhage and Their Applications
  • Biomarkers for Early Detection of Severity and Prognosis Evaluation of Aneurysmal Subarachnoid Hemorrhage and Their Applications
  • Biomarkers for Early Detection of Severity and Prognosis Evaluation of Aneurysmal Subarachnoid Hemorrhage and Their Applications

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Embodiment

[0055] 1. Acquisition of CSF samples from patients: This study selected 40 CSF samples from patients within 1 day after the rupture of intracranial aneurysms admitted to the Neurosurgery Department of Tai'an Central Hospital from February 2016 to January 2018. This research protocol was approved by the Ethics Committee of Tai'an Central Hospital (No. 2016-05-003). The patient underwent interventional embolization and aneurysm craniotomy and clipping. Injury severity refers to GCS score and Hunt-Hess classification. Six months after operation, mRS score was used to conduct telephone follow-up to evaluate the prognosis.

[0056] 2. Inclusion criteria and exclusion criteria: (1) aged between 40 and 70 years old, (2) receiving only interventional embolization, (3) SAH caused by single responsibility aneurysm. Exclusion criteria: (1) converted to craniotomy during craniotomy clipping or interventional embolization; (2) SAH caused by multiple responsible aneurysms; (3) intraoperat...

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Abstract

The invention provides a marker for early detection of severity and prognosis evaluation of aneurysmal subarachnoid hemorrhage and application thereof, belonging to the technical field of molecular diagnosis and molecular biology. The presence of CBS, DAO and 3-MST in CSF and its correlation with inflammatory parameters in SAH patients and rats, thus proving the expression level of CBS, DAO and 3-MST is correlated with the prognosis of patients, so it can be used as a biomarker for early detection of the severity of aneurysmal subarachnoid hemorrhage and prognosis evaluation, providing a new method for monitoring aSAH and prognosis evaluation, and helping to improve the diagnosis and treatment effect of this kind of disease.

Description

technical field [0001] The invention belongs to the technical field of molecular diagnosis and molecular biology, and specifically relates to a biomarker for early detection of aneurysmal subarachnoid hemorrhage severity and prognosis assessment and application thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Aneurysmal subarachnoid hemorrhage (aSAH) is a serious life-threatening cerebrovascular disease with high morbidity and mortality. In recent years, acute injury within 72 hours after aSAH (early brain injury) is considered to be the main cause of poor prognosis. The pathological process is complex, mainly including mitochondrial dysfunction, inflammation,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/527C12Q1/48C12Q1/26G01N33/68
CPCC12Q1/26C12Q1/48C12Q1/527G01N33/6869G01N33/6893G01N2333/5412G01N2333/90644G01N2333/91194G01N2800/2871G01N2800/52
Inventor 王贞韩敏刘德祥
Owner SHANDONG UNIV