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Diagnosis-treatment integrated nanometer material, diagnosis-treatment integrated nanometer preparation and preparation method of nanometer preparation

A nano-material and nano-preparation technology, applied in the field of nano-materials, can solve problems such as delayed treatment timing, increased pain and risk of cancer patients, and long intervals, and achieve favorable treatment effects

Inactive Publication Date: 2014-06-18
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Nanoprobes can detect tumors, and nanomedicines can treat tumors, but both nanoprobes and nanomedicines have only a single function, and they need to be administered separately during treatment and detection.
Cancer patients usually use nanoprobes in order to receive corresponding instrument diagnosis; during treatment, they also need to use other cancer treatment drugs, which will not only increase the financial burden of patients, but also increase the pain and pain of two medications in the two medical procedures of cancer patients. Risk, and the time interval between two medical procedures is long, it is easy to delay the best treatment time

Method used

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  • Diagnosis-treatment integrated nanometer material, diagnosis-treatment integrated nanometer preparation and preparation method of nanometer preparation

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preparation example Construction

[0039] see figure 2 , the preparation method of the integrated nano-preparation of diagnosis and treatment of one embodiment, comprising the following steps:

[0040] Step S110: Mix the indocyanine green solution, the polyene taxol solution and the poly(lactic-co-glycolic acid) solution at a volume ratio of 1:0.5-2:10 to obtain a first mixed solution.

[0041] A certain amount of indocyanine green is dissolved in ultrapure water to prepare an indocyanine green solution. The concentration of the indocyanine green solution is preferably 0.5-1 mg / mL.

[0042] A certain amount of docetaxel is dissolved in methanol to prepare a docetaxel solution, and the concentration of the docetaxel solution is preferably 1-5 mg / mL.

[0043] A certain amount of polylactic acid-glycolic acid copolymer is dissolved in acetonitrile to prepare a polylactic acid-glycolic acid copolymer solution, and the concentration of the polylactic acid-glycolic acid copolymer solution is preferably 1-5 mg / mL. ...

Embodiment 1

[0060] Preparation of integrated nano-preparation for diagnosis and treatment

[0061] (1) Dissolve an appropriate amount of ICG in ultrapure water to obtain an ICG solution with a concentration of 0.5 mg / mL;

[0062] (2) Dissolve an appropriate amount of docetaxel in methanol to obtain a docetaxel solution with a concentration of 1 mg / mL;

[0063] (3) Dissolve an appropriate amount of PLGA in acetonitrile to obtain a PLGA acetonitrile solution with a concentration of 2 mg / mL;

[0064] (4) Take 100 μL of ICG solution, 100 μL of docetaxel solution and 1 mL of PLGA acetonitrile solution for ultrasonic mixing to obtain the first mixed solution;

[0065] (5) Take an appropriate amount of DSPE-PEG-Folate and an appropriate amount of soybean lecithin and dissolve them respectively in a mixed solvent of chloroform and methanol with a volume ratio of 9:1 to obtain a DSPE-PEG-Folate solution with a concentration of 25 mg / ml and a concentration of 1mg / ml soybean lecithin solution;

...

Embodiment 2

[0073] Preparation of integrated nano-preparation for diagnosis and treatment

[0074] (1) Dissolve an appropriate amount of ICG in ultrapure water to obtain an ICG solution with a concentration of 1 mg / mL;

[0075] (2) Dissolve an appropriate amount of docetaxel in methanol to obtain a docetaxel solution with a concentration of 2 mg / mL;

[0076] (3) Dissolve an appropriate amount of PLGA in acetonitrile to obtain a PLGA acetonitrile solution with a concentration of 2 mg / mL;

[0077] (4) Take 100 μL of ICG solution, 50 μL of docetaxel solution and 1 mL of PLGA acetonitrile solution for ultrasonic mixing to obtain the first mixed solution;

[0078] (5) Take an appropriate amount of DSPE-PEG-Folate and an appropriate amount of soybean lecithin and dissolve them respectively in a mixed solvent of chloroform and methanol with a volume ratio of 9:1 to obtain a DSPE-PEG-Folate solution with a concentration of 25 mg / ml and a concentration of 1mg / ml soybean lecithin solution;

[00...

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Abstract

The invention provides a diagnosis-treatment integrated nanometer material. The material comprises multiple nanometer particles, each nanometer particle comprises a core formed by a mixture of indocyanine green and docetaxel, an inner shell formed by coating a polylactic-co-glycolic acid on the surface of the core, an outer shell formed by coating soya lecithin and distearoyl phosphoethanolamine-polyethylene glycol-folic acid on the surface of the inner shell, and distearoyl phosphoethanolamine-polyethylene glycol-folic acid interpenetrates soya lecithin. The diagnosis-treatment integrated nanometer material also has the functions of diagnosing and treating cancers. The invention also provides a diagnosis-treatment integrated nanometer preparation and a preparation method thereof.

Description

technical field [0001] The invention relates to the field of nanometer materials, in particular to a nanometer material integrated with diagnosis and treatment, a nanometer preparation integrated with diagnosis and treatment and a preparation method thereof. Background technique [0002] Nanoprobes can detect tumors, and nanomedicines can treat tumors, but both nanoprobes and nanomedicines have only a single function, and they need to be administered separately for treatment and detection. Cancer patients usually use nanoprobes in order to receive corresponding instrument diagnosis; during treatment, they also need to use other cancer treatment drugs, which will not only increase the economic burden of patients, but also increase the pain and pain of two medications in the two medical procedures of cancer patients. Risk, and the time interval between the two medical procedures is long, it is easy to miss the best time for treatment. Contents of the invention [0003] Base...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K9/16A61K31/337A61K47/34A61P35/00
Inventor 蔡林涛郑翠芳郑明彬龚萍
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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