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Abamectin nanopesticide preparation and preparation method thereof

A technology of abamectin and nano-pesticides, applied in the field of pesticides, can solve the problems of reduced drug efficacy and effective utilization rate, abamectin is easy to decompose when exposed to light, and the application amount of abamectin is increased. Effective utilization rate and bioavailability, good anti-photodegradation performance, effect of improving drug efficacy and effective utilization rate

Active Publication Date: 2020-12-29
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual use, abamectin is easy to decompose when exposed to light and has poor water solubility, which leads to an increase in the application amount of abamectin, a decrease in drug efficacy and effective utilization rate, and poor slow-release performance, which limits its application in agriculture.

Method used

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  • Abamectin nanopesticide preparation and preparation method thereof
  • Abamectin nanopesticide preparation and preparation method thereof
  • Abamectin nanopesticide preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] The preparation of embodiment 1 Abamectin nanopesticide preparation

[0091] Add 1 g sodium carboxymethyl cellulose and 40 ml sulfuric acid solution (25% v / v) into a 100 mL beaker, stir and react at room temperature for 2 h, then centrifuge and wash the product to neutrality to obtain carboxymethyl cellulose.

[0092] Put 1g of carboxymethylcellulose, 1.5g of DCC, 1.5g of DMAP and 1.6g of mPEG-CM obtained above into a round bottom flask, add 30ml of DMF, and react at 35°C for 5h to obtain an intermediate product; Vermectin was dissolved in 20ml DMF and slowly added to the round-bottomed flask containing the intermediate product, reacted overnight at 40°C, and the next day the reaction product was purified and dried at 40°C to obtain grafted avermectin product.

[0093] The avermectin graft product obtained above was dissolved in DMSO, then molecular self-assembly was carried out in water, and after 3 days, the product was freeze-dried to obtain a solid powder avermecti...

Embodiment 2

[0094] The preparation of embodiment 2 Abamectin nanopesticide preparations

[0095] Add 0.5 g of sodium carboxymethyl cellulose and 40 ml of sulfuric acid solution (25% v / v) into a 100 mL beaker, stir and react at room temperature for 1.5 h, then centrifuge and wash the product to neutrality to obtain carboxymethyl cellulose.

[0096] Put 0.5g carboxymethylcellulose, 1.3g DCC, 1.3g DMAP and 1.8g mPEG-CM obtained above into a round bottom flask, add 30ml DMF, and react at 32°C for 5.5h to obtain an intermediate product; 2g of abamectin was dissolved in 15ml of DMF and slowly added to the round bottom flask containing the intermediate product, reacted overnight at 30°C, the next day the reaction product was purified, and dried at 30°C to obtain abamectin branch product.

[0097] The avermectin graft product obtained above was dissolved in DMSO, then molecular self-assembly was carried out in water, and after 2.5 days, the product was freeze-dried to obtain a solid powder abame...

Embodiment 3

[0098] The preparation of embodiment 3 Abamectin nanopesticide preparation

[0099] Add 0.8g sodium carboxymethylcellulose and 40ml sulfuric acid solution (15% v / v) into a 100mL beaker, stir and react at room temperature for 1.7h, then centrifuge and wash the product to neutrality to obtain carboxymethylcellulose.

[0100] Put 0.8g of carboxymethylcellulose, 1g of DCC, 0.9g of DMAP and 1.4g of mPEG-CM obtained above into a round bottom flask, add 30ml of DMF, and react at 30°C for 6h to obtain an intermediate product; then 2.4g Abamectin was dissolved in 17ml of DMF and slowly added to the round bottom flask containing the intermediate product, reacted overnight at 35°C, and the next day the reaction product was purified and dried at 45°C to obtain grafted avermectin product.

[0101] The avermectin graft product obtained above was dissolved in DMSO, then molecular self-assembly was carried out in water, and the product was freeze-dried after 2 days to obtain a solid powder a...

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Abstract

The invention provides an abamectin nano pesticide preparation and a preparation method thereof. The abamectin nano pesticide preparation is prepared from the following components in parts raw material: 2 to 4.1 parts of abamectin, 0.5 to 1.5 parts of sodium carboxymethylcellulose, 1 to 2 parts of N, N-dicyclohexylcarbodiimide, 0.9 to 2.2 parts of 4-dimethylaminopyridine and 1 to 2.1 parts of methoxy-polyethylene glycol-carboxyl. The abamectin nano pesticide preparation is small in particle size, small in contact angle on leaf surfaces, good in photolysis resistance, good in esterase responseslow-release characteristic, remarkable in insecticidal effect on hyphantria cunea larvae, high in pesticide effect and effective utilization rate and good in application prospect, the agricultural control cost is greatly reduced, and the abamectin nano pesticide preparation has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of pesticides. Specifically, the present invention relates to a kind of abamectin nanopesticide preparation and preparation method thereof. Background technique [0002] Pesticides play an important role in controlling pest hazards, ensuring agricultural production safety, and increasing crop yields. The irrational use of pesticides has caused many adverse effects on human health and the ecological environment. In recent years, many sustained-release formulations of pesticides have appeared on the market. These pesticide formulations have many advantages, such as reducing the amount of pesticides used, prolonging the duration of pesticides, reducing the toxicity of highly toxic pesticides, and reducing the toxicity to non-target organisms. At present, nano-pesticides prepared by applying nanotechnology to the field of pesticides can significantly improve the water-solubility and dispersibility of pesticides...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/32A01N25/10A01P7/04A01P5/00
CPCA01N25/10A01N25/32A01N43/90
Inventor 王琰崔海信申越朱华新张燕卿
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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