Preparation method of multi-functional nanometer material having good sun-proof effects

A nanomaterial and multifunctional technology, applied in the field of preparation of multifunctional nanomaterials, can solve the problems of serious photocatalytic activity, damage to cells and DNA, carcinogenicity, etc., and achieve good sun protection effect, low cytotoxicity, and large load effect

Active Publication Date: 2020-02-18
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although compared with organic sunscreens, inorganic sunscreens avoid the hidden danger of skin penetration, but they have serious photocatalytic activity, and the large amount of free radicals produced can damage cells and DNA, and eventually cause cancer

Method used

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  • Preparation method of multi-functional nanometer material having good sun-proof effects
  • Preparation method of multi-functional nanometer material having good sun-proof effects
  • Preparation method of multi-functional nanometer material having good sun-proof effects

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Embodiment

[0033] A preparation of a multifunctional nanomaterial with better sunscreen effect, the specific operation steps are as follows:

[0034] 1) Preparation of bismuth titanate silicon spheres (BTO-DSM) with physical sunscreen properties:

[0035] At room temperature, 0.5 g of cetyltrimethylammonium bromide was added to a mixed solution containing 70 mL of water, 0.8 mL of ammonia water, 20 mL of ether and 10 mL of ethanol and stirred for half an hour. 2.5mL tetraethyl orthosilicate and 0.05mL triaminopropyltrimethoxysilane were quickly added to the above solution in sequence and continued to stir for 4 hours, and the white precipitate after the reaction was washed with water and ethanol and dried. The obtained white solid was stirred in a mixed solution of 15 mL ethanol and 105 mL hydrochloric acid at 70° C. for 1 day, washed with water and ethanol, and oven-dried at 60° C. to obtain dendritic silica microspheres (DSM).

[0036] 0.3 g of DSM and 0.128 mL of titanium tetraisopropo...

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Abstract

The invention relates to a preparation method of a multi-functional nanometer material having good sun-proof effects, and belongs to the technical field of skin care products. The preparation method is characterized by comprising the steps of enabling a layer of nanometer-grade titanium dioxide to grow on the surface of arborization nanometer silicon dioxide, under high temperature, enabling bismuth ions to dissolve in the surfaces of the titanium dioxide, forming the nanometer material using bismuth titanate as a main component, performing amination modification on the silicon dioxide, further, enabling a carboxyl-containing chemical sun-screening agent namely a malic acid analog to be connected to the surfaces of silicon spheres by using an amino-carboxyl reaction, and finally, through an opposite electrical potential attraction principle, modifying baicalin to the outermost layer of the nanometer material. According to the method, a physical sun-screening agent, a chemical sun-screening agent ad a free radical scavenger are combined at the same time to nanometer silicon dioxide, compared with other materials, the prepared nanometer sun-proof material has the advantages that theultraviolet ray absorption range is broader, the ultraviolet screening effect is better, and the photocatalysis toxicity is lower. Due to good ultraviolet ray resistant properties and low photocatalytic activity, the multi-functional nanometer material can be widely applied to the field of bio-pharmaceutical.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to the preparation of a multifunctional nanomaterial with better sunscreen effect. Background technique [0002] Long-term exposure of the skin to UV radiation from the sun can lead to a variety of adverse effects, such as sunburn, skin aging and even skin cancer. Additionally, exposure to UV light increases the production of free radicals, which can damage gDNA and lead to immunosuppressive cytokines. Applying sunscreen with UV protection to the skin can protect the skin from the above damage. [0003] At present, the active ingredients of sunscreen products that are widely used are mainly divided into chemical sunscreens and physical sunscreens. Organic sunscreens such as avobenzone, octocrylene, and isoamyl p-dimethylaminobenzoate have been added to commercial sunscreens in large quantities over the past few decades. However, the skin permeability of organic sunscreens and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/29A61K8/25A61K8/19A61K8/60A61Q17/04
CPCA61K8/19A61K8/25A61K8/29A61K8/602A61K2800/413A61Q17/04
Inventor 董海峰乔玉春
Owner UNIV OF SCI & TECH BEIJING
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