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Application of dehydroevodiamine in preparation of drug used for treating acute gastritis

A technology for dehydroevodiamine and acute gastritis, which is applied to the application field of dehydroevodiamine in the preparation of medicines for treating acute gastritis, can solve problems such as the absence of dehydroevodiamine on acute gastritis, and achieves improvement of SOD level and improvement Significant effect, ulceration reduction effect

Inactive Publication Date: 2020-03-27
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no records and reports about the protective effect of dehydroevodiamine on acute gastritis in the prior art

Method used

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  • Application of dehydroevodiamine in preparation of drug used for treating acute gastritis
  • Application of dehydroevodiamine in preparation of drug used for treating acute gastritis
  • Application of dehydroevodiamine in preparation of drug used for treating acute gastritis

Examples

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Effect test

experiment example 1

[0019] Experimental example 1 : Evaluate the therapeutic effect of the target compound (dehydroevodiamine) on acute gastritis by using the acute gastritis model induced by absolute ethanol in mice:

[0020] 1. Method: After adapting to the environment for 1 week, the mice were randomly divided into 4 experimental groups (control group, model group, evodiamine dosage group and dehydroevodiamine dosage group), each group containing 10 animals, Intragastric administration once a day for three consecutive days. The mice in the control group received 1% CMC (sodium carboxymethyl cellulose); the mice in the model group received 1% CMC; the evodiamine dose group was given 20 mg / kg of evodiamine by intragastric administration, and the dehydroevodiamine dose group was given dehydroevodiamine by intragastric administration. Evodiamine 20mg / kg. Before the experiment, the mice were fasted for 12 hours but had free access to water. Then the mice were treated as above, 0.01ml / g dose of ...

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Abstract

The invention provides an application of dehydroevodiamine in preparation of a drug used for treating acute gastritis, and relates to the field of biological medicines. According to the application ofthe dehydroevodiamine in preparation of the drug used for treating the acute gastritis, the dehydroevodiamine can significantly improve the gastric mucosa MDA and SOD levels of mice with the acute gastritis, and the dehydroevodiamine can significantly reduce the gastric mucosal ulcer index of the mice. The drug used for treating the acute gastritis is prepared from the dehydroevodiamine with an effective amount and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier is selected from the group consisting of a diluent, a disintegrating agent, an adhesive, a lubricant and a stabilizer. The dehydroevodiamine provided by the invention has the following advantages: 1, the dehydroevodiamine can significantly improve the gastric mucosa MDA and SOD levels of theacute gastritis mice; and 2, the dehydroevodiamine can significantly reduce the gastric mucosa ulcer index of the mice;

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of dehydroevodiamine in the preparation of medicines for treating acute gastritis. Background technique [0002] Acute gastritis is a transient disease mainly manifested by extensive or localized hyperemia, edema, hemorrhage, and erosion of the gastric mucosa caused by drugs, stress, ischemia, infection, and bile reflux. Simple gastritis, acute erosive gastritis, acute corrosive gastritis, acute suppurative gastritis, common and frequently-occurring diseases in digestive system diseases, mild patients with nausea, acid regurgitation, stomach burning sensation, abdominal fullness, abdominal pain , mainly diarrhea; severe patients may experience symptoms such as hematemesis, melena, and even poisoning, dehydration, and shock. At present, the main clinical treatment is symptomatic treatment. Relief of pain is the main purpose of clinical treatment of acute gastritis. Comm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K36/754A61P1/04
CPCA61K31/519A61K36/754A61P1/04
Inventor 赵艳玲魏士长李浩田任思陈韦颖
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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