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Preparation technology of drug for treating stomach illness

A preparation process and technology of medicine, which is applied in the field of medicine preparation technology, can solve problems such as difficult detection, difficult detection of active ingredients of medicines, unsatisfactory clinical curative effect of Shuangjin stomach ulcer preparation, etc., to achieve remarkable drug effect and good clinical curative effect Effect

Inactive Publication Date: 2016-09-14
贵州三仁堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors found in the course of their research that the active ingredients in the medicine are not easy to detect in the Shuangjin gastric ulcer preparation prepared by the existing extraction process, especially the active ingredient 2,7-dihydroxy-4-formazan in Baiji. Oxygen-9,10-dihydrophenanthrene-dihydrophenanthrene is not easy to detect, which makes the clinical efficacy of Shuangjin stomach ulcer preparation not ideal enough

Method used

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  • Preparation technology of drug for treating stomach illness
  • Preparation technology of drug for treating stomach illness
  • Preparation technology of drug for treating stomach illness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Recipe: 42g Snow Gallbladder, 32g Golden Buckwheat, 32g Daxueteng, 21g Purple Pearl, 32g Burlap Bag, 32g Corydalis Corydalis, 32g Agrimony, 63g Baiji, 42g Fenghuangyi, 32g Tumuxiang and 40g walnut kernel.

[0076] Process: Take the white root, add 8 times the amount of water, adjust the pH to 1.5 with hydrochloric acid, soak for 2 hours, decoct for 2.5 hours, filter while it is hot, and get the water extract, and set aside; add 8 times the amount of water to the dregs, sodium hydroxide solution Adjust the pH to 10, decoct for 3 times, each time for 1 hour, filter while hot, combine the filtrate, mix the filtrate with the above water extract, concentrate it into an extract with a relative density of 1.1-1.2 at 50-60°C, dry, and pulverize to obtain White and dry cream powder, for later use; take inulin, add 8 times the amount of cold water at 1-5°C to soak for 1 hour, soak at 75-80°C, 0.07-0.08MPa for 3 times, each time for 2.5 hours, filter, and combine the filtrates For...

Embodiment 2

[0081] Recipe: 52g of snow gall, 42g of golden buckwheat, 42g of Daxueteng, 26g of purple pearl, 42g of burlap bag, 42g of Corydalis 42g, 42g of Agrimony, 70g of Baiji, 52g of Phoenix clothes, 42g of Tumuxiang, 50g of walnut kernels and accessories.

[0082] Process: Take the white root, add 8 times the amount of water, adjust the pH to 1.5 with hydrochloric acid, soak for 2 hours, decoct for 2.5 hours, filter while it is hot, and get the water extract, and set aside; add 8 times the amount of water to the dregs, sodium hydroxide solution Adjust the pH to 10, decoct for 3 times, each time for 1 hour, filter while hot, combine the filtrate, mix the filtrate with the above water extract, concentrate it into an extract with a relative density of 1.1-1.2 at 50-60°C, dry, and pulverize to obtain White and dry cream powder, for later use; take inulin, add 8 times the amount of cold water at 1-5°C to soak for 1 hour, soak at 75-80°C, 0.07-0.08MPa for 3 times, each time for 2.5 hours, ...

Embodiment 3

[0087] Recipe: 32g snow gallbladder, 22g golden buckwheat, 22g blood vine, 15g purple pearl, 22g burlap bag, 22g corydalis, 22g Agrimony, 55g white and phoenix clothes, 32g phoenix clothes, 22g Tumuxiang, 30g walnut kernels and accessories.

[0088] Process: Take the white root, add 8 times the amount of water, adjust the pH to 1.5 with hydrochloric acid, soak for 2 hours, decoct for 2.5 hours, filter while it is hot, and get the water extract, and set aside; add 8 times the amount of water to the dregs, sodium hydroxide solution Adjust the pH to 10, decoct 3 times, each time for 1 hour, filter while hot, combine the filtrate, mix the filtrate with the above water extract, concentrate it into an extract with a relative density of 1.1-1.2 at 50-60°C, dry, and pulverize to obtain White and dry paste powder, for later use; take inulin, add 8 times the amount of cold water at 1-5°C to soak for 1 hour, soak at 75-80°C, 0.07-0.08MPa for 3 times, each time for 2.5 hours, filter, and c...

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Abstract

The invention discloses a preparation technology of a drug for treating stomach illness. The drug is mainly composed of hemsleya amabilis, wild buckwheat, sargentgloryvine stem, folium callicarpae pedunculalae, root of aconitum sinomontanum, corydalis tuber, hairyvein agrimony, bletilla rhizome, membrane of hen egg, elecampane, and walnut kernel. Based on the properties and functions of each component of Shuangjin gastric ulcer preparation, the specific manufacturing technology and parameters are improved, so that the effective component of bletilla rhizome namely 2,7-dihydroxyl-4-methoxyl-9,10-dihydro phenanthrene can be easily measured, moreover, the content of 2,7-dihydroxyl-4-methoxyl-9,10-dihydro phenanthrene is high, the drug effect is more prominent, and the clinical effect is good.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation process of a medicine for treating stomach diseases. Background technique [0002] Extraction of traditional Chinese medicine is a method commonly used in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex, and it is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture. to improve efficacy. [0003] Shuangjin Gastric Ulcer Preparation is mainly made of Snow Gallbladder, Golden Buckwheat, Daxueteng, Purple Pearl, Burlap Bag, Corydalis Corydalis, Agrimony, Baiji, Fenghuangyi, Tumuxiang and walnut kernel; , the effect of astringent and hemostasis, used for epigastric tingling caused by stagnation of liver and stomach qi and blood stasis, vomiting and acid regurgitation, abdominal distension and p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/16A61K9/20A61K9/48A61P1/00A61P1/08A61P1/14A61P1/04A61K35/57
CPCA61K36/42A61K9/1623A61K9/2059A61K9/2068A61K9/4808A61K35/57A61K36/185A61K36/28A61K36/52A61K36/66A61K36/70A61K36/714A61K36/73A61K36/85A61K36/898A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 雷华鼎
Owner 贵州三仁堂药业有限公司
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