Application of dehydroevodiamine in preparation of medicine for treating acute gastritis
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for dehydroevodiamine and acute gastritis, which is applied to the application field of dehydroevodiamine in the preparation of medicines for treating acute gastritis, can solve problems such as the absence of dehydroevodiamine on acute gastritis and the like, and achieves improvement of SOD level and ulcers. Formation of significant reduction and improvement effects
Inactive Publication Date: 2021-05-11
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
So far, there are no records and reports about the protective effect of dehydroevodiamine on acute gastritis in the prior art
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
experiment example 1
[0019] Experimental example 1 : Evaluate the therapeutic effect of the target compound (dehydroevodiamine) on acute gastritis by using the acute gastritis model induced by absolute ethanol in mice:
[0020] 1. Method: After adapting to the environment for 1 week, the mice were randomly divided into 4 experimental groups (control group, model group, evodiamine dosage group and dehydroevodiamine dosage group), each group containing 10 animals, Intragastric administration once a day for three consecutive days. The mice in the control group received 1% CMC (sodium carboxymethyl cellulose); the mice in the model group received 1% CMC; the evodiamine dose group was given 20 mg / kg of evodiamine by intragastric administration, and the dehydroevodiamine dose group was given dehydroevodiamine by intragastric administration. Evodiamine 20mg / kg. Before the experiment, the mice were fasted for 12 hours but had free access to water. Then the mice were treated as above, 0.01ml / g dose of ...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The application of dehydroevodiamine in the preparation of medicines for treating acute gastritis of the present invention relates to the field of biomedicine. Application of dehydroevodiamine in preparation of medicine for treating acute gastritis. Among them, dehydroevodiamine can significantly improve the levels of MDA and SOD in the gastric mucosa of mice with acute gastritis. Among them, dehydroevodiamine can significantly reduce the gastric mucosal ulcer index in mice. The medicine for treating acute gastritis comprises effective dose of dehydroevodiamine and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier is diluent, disintegrant, binder, lubricant or stabilizer. The invention has the following advantages: 1. Dehydroevodiamine can significantly improve the levels of MDA and SOD in the gastric mucosa of mice with acute gastritis; 2. The dehydroevodiamine can significantly reduce the gastric mucosal ulcer index in mice.
Description
technical field [0001] The invention relates to the field of biomedicine, in particular to the application of dehydroevodiamine in the preparation of medicines for treating acute gastritis. Background technique [0002] Acute gastritis is a transient disease mainly manifested by extensive or localized hyperemia, edema, hemorrhage, and erosion of the gastric mucosa caused by drugs, stress, ischemia, infection, and bile reflux. Simple gastritis, acute erosive gastritis, acute corrosive gastritis, acute suppurative gastritis, common and frequently-occurring diseases in digestive system diseases, mild patients with nausea, acid regurgitation, stomach burning sensation, abdominal fullness, abdominal pain , mainly diarrhea; severe patients may experience symptoms such as hematemesis, melena, and even poisoning, dehydration, and shock. At present, the main clinical treatment is symptomatic treatment. Relief of pain is the main purpose of clinical treatment of acute gastritis. Comm...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K36/754A61P1/04
CPCA61K31/519A61K36/754A61P1/04
Inventor 赵艳玲魏士长李浩田任思陈韦颖
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
Login to view more 
Login to view more