Lindera reflexa hemsl active ingredient composition with prevention and treatment effect on gastric ulcer as well as preparation method and application thereof

A technology for active ingredients and compositions, applied in the field of active ingredient compositions and preparations thereof, can solve the problems such as no public reports, complex composition of total flavonoids, unfavorable clinical research and new drug development, etc., and achieve significant gastric protection. and therapeutic effects, enhancing anti-oxidative stress, preventing and treating gastric ulcers

Pending Publication Date: 2021-12-28
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preliminary studies have found that the anti-ulcer activity of the total flavonoids of Shanxie is better, but the components of the total flavonoids are relatively complex, not only containing flavonoids, but also stilbenes. Extremely unfavorable
How to screen out one or a group of compounds that have the same or better effect on treating gastric ulcers and create good social and economic benefits is a technical problem that those skilled in the art need to solve. public report

Method used

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  • Lindera reflexa hemsl active ingredient composition with prevention and treatment effect on gastric ulcer as well as preparation method and application thereof
  • Lindera reflexa hemsl active ingredient composition with prevention and treatment effect on gastric ulcer as well as preparation method and application thereof
  • Lindera reflexa hemsl active ingredient composition with prevention and treatment effect on gastric ulcer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]The present invention is an active component composition (group) of Chinese sage with preventive effect on gastric ulcer. -O-β-D-glucoside, silver pinocin, 3-methoxy-5-hydroxy-trans-stilbene, 3,5-dimethoxy-trans-stilbene, 3,5 -Dihydroxy-4-[(3”R4”S)-p-menthenyl]-trans-stilbene, 3,5-dihydroxy-2-[(3”R4”R)-p-menthenyl ]-trans-stilbene, 3,5-dihydroxy-2,6-di-[(3"R4"R3"'S4"'S)-p-menthenyl]-trans-stilbene and 3,5-dihydroxy-2,4-di-[(3"R4"S3"'R4"'S)-p-menthenyl]-trans-stilbene in mass content percentage 4.57%, 28.95%, Mix 7.56%, 5.29%, 10.44%, 28.78%, 9.25%, and 5.16%, dissolve in methanol, add water twice the weight of the drug, and form a suspension of the active ingredient composition of the sage, freeze-dry to obtain the active ingredient of the sage Compositions; the silver-pinene-3,5-di-O-β-D-glucoside, silver-pinene, 3-methoxy-5-hydroxyl-trans-stilbene, 3,5- Dimethoxy-trans-stilbene, 3,5-dihydroxy-4-[(3”R4”S)-p-menthenyl]-trans-stilbene, 3,5-dihydroxy- 2-[(3”R4”R)-p-men...

Embodiment 2

[0054] The present invention is an active ingredient composition (group) of Chinese sage with preventive effect on gastric ulcer. O-β-D-glucoside, silver pinone, 3-methoxy-5-hydroxy-trans-stilbene, 3,5-dimethoxy-trans-stilbene, 3,5- Dihydroxy-4-[(3”R4”S)-p-menthenyl]-trans-stilbene, 3,5-dihydroxy-2-[(3”R4”R)-p-menthenyl] -trans-stilbene, 3,5-dihydroxy-2,6-di-[(3"R4"R3"'S4"'S)-p-menthenyl]-trans-stilbene and 3 ,5-Dihydroxy-2,4-di-[(3”R4”S3”'R4”'S)-p-menthenyl]-trans-stilbene in mass content percentage 3.67%, 31.64%, 6.06 %, 5.89%, 8.36%, 31.12%, 7.41%, and 5.85% are mixed, dissolved in methanol, and then water twice the weight of the drug is added to form a suspension of the active ingredient composition of S. thing.

Embodiment 3

[0056] The present invention is an active ingredient composition (group) of Chinese sage with preventive effect on gastric ulcer. O-β-D-glucoside, silver pinone, 3-methoxy-5-hydroxy-trans-stilbene, 3,5-dimethoxy-trans-stilbene, 3,5- Dihydroxy-4-[(3”R4”S)-p-menthenyl]-trans-stilbene, 3,5-dihydroxy-2-[(3”R4”R)-p-menthenyl] -trans-stilbene, 3,5-dihydroxy-2,6-di-[(3"R4"R3"'S4"'S)-p-menthenyl]-trans-stilbene and 3 ,5-dihydroxy-2,4-di-[(3”R4”S3”'R4”'S)-p-menthenyl]-trans-stilbene in mass content percentage 5.47%, 25.69%, 9.06 %, 4.85%, 12.52%, 26.67%, 11.09%, and 4.65% are mixed, dissolved in methanol, and then water twice the weight of the drug is added to form a suspension of the active ingredient composition of Shanxi, freeze-dried to obtain the active ingredient combination of Shanxi thing.

[0057] The present invention is the composition of 8 effective active ingredients extracted from sage, the preparation method is scientific, reasonable, and easy to operate, and the 8 acti...

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Abstract

The invention relates to a lindera reflexa hemsl active ingredient composition with prevention and treatment effects on gastric ulcer as well as a preparation method and application of the lindera reflexa hemsl active ingredient composition, effectively solves the problem that the lindera reflexa hemsl active ingredient composition can treat the gastric ulcer and can prevent and reduce the occurrence of the gastric ulcer. The preparation method comprises the following steps: mixing pinobenzene-3, 5-di-O-beta-D-glucoside, pinobenzene, 3-methoxy-5-hydroxy-trans-stilbene, 3, 5-dimethoxy-trans-stilbene, 3, 5-dihydroxy-4-[(3 "R4" S)-p-menthenyl]-trans-stilbene, 3, 5-dihydroxy-2-[(3 "R4" R)-p-menthenyl]-trans-stilbene, 3, 5-dihydroxy 2, 6-di-[(3 "R4"S3'''R4'''S)-p-menthenyl]-trans-stilbene and 3, 5-dihydroxy 2, 4-di-[(3" R4''S3'''R4'''S)-p-menthenyl]-trans-stilbene , dissolving with methanol, adding water, suspending, and freeze-drying; the preparation method is scientific, reasonable and easy to operate, the anti-oxidative stress capacity of stomach tissue is improved, inflammation is relieved, gastric ulcer repair is promoted, and remarkable stomach protection and treatment effects are achieved.

Description

technical field [0001] The present invention relates to the technical field of biological medicines, in particular to a composition (group) of active ingredients of mountain persimmons which has the effect of preventing and treating gastric ulcer, its preparation method and application. Background technique [0002] Gastric ulcer is a clinically common digestive system disease, its main features are necrosis, hemorrhage, inflammatory cell infiltration and decreased blood flow, and gastric perforation or even canceration may occur in severe cases. The pathogenesis of gastric ulcer is relatively complicated, and it is currently considered to be mainly due to the imbalance of defense factors (bicarbonate, prostaglandin and nitric oxide) and attack factors (gastric acid and pepsin) of gastric mucosa. In addition, long-term use of non-steroidal anti-inflammatory drugs, excessive drinking and smoking, excessive mental stress and Helicobacter pylori infection can also lead to gastr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034
CPCA61K31/7034A61K31/05A61K31/085A61K31/09A61P1/04C07H1/08C07H15/203C07C37/004C07C37/82C07C41/36C07C2601/16C07C39/21C07C39/23C07C43/23C07C43/2055
Inventor 陈随清付宇航孙孝亚段懿哲侯亚迪
Owner HENAN UNIV OF CHINESE MEDICINE
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