Method for enhancing osteogenic ability of human umbilical cord mesenchymal stem cells
A technology of mesenchymal stem cells and osteogenic ability, applied in the field of enhancing the osteogenic ability of human umbilical cord mesenchymal stem cells, can solve the problems of cell differentiation and insufficient osteogenic ability, and achieve good compatibility
Pending Publication Date: 2020-03-27
STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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Problems solved by technology
[0006] The technical problem to be solved in the present invention is to overcome the existing problems of insufficient cell differentiation and osteogenic ability, and provide a method for enhancing the osteogenic ability of human umbilical cord mesenchymal stem cells
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[0040] Materials and methods:
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Abstract
The invention provides a method for enhancing the osteogenic ability of human umbilical cord mesenchymal stem cells. The method comprises the following steps: providing human umbilical cord mesenchymal stem cells, respectively performing osteogenesis and endothelium two-way pre-induction differentiation on the human umbilical cord mesenchymal stem cells, and performing mixed co-culture on the twodifferentiated cells to obtain cells with relatively strong osteogenic ability. The method successfully prepares the bi-differentiated human umbilical cord mesenchymal stem cells with relatively strong osteogenic ability, the cells have good compatibility with a beta-calcium triphosphate scaffold, and a new method is provided for an application of the human umbilical cord mesenchymal stem cells intissue engineered bone.
Description
technical field [0001] The invention relates to the field of biotechnology, in particular to a method for enhancing the osteogenic ability of human umbilical cord mesenchymal stem cells. Background technique [0002] Trauma, infection, tumor resection, and congenital malformation can all lead to severe bone defects, affecting the shape and function of the patient's maxillofacial region. The "gold standard" autologous bone graft repair needs to open up a second operating area, which will cause new bone defects and cause severe bone defects. The patient's physical, psychological and economic burdens are huge, and the repair effect is not ideal. The stem cell-based tissue-engineered bone graft combined with three-dimensional (3D) printing can repair bone defects in a non-invasive, safe and personalized manner, and has broad application prospects. [0003] Stem cells include adult stem cells, perinatal stem cells, embryonic stem cells, and induced pluripotent stem cells. The a...
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Patent Timeline
Login to view more IPC IPC(8): C12N5/077C12N5/0775C12N5/071A61L27/38
CPCC12N5/0668C12N5/0654C12N5/069A61L27/3834C12N2501/39C12N2500/38C12N2500/42C12N2500/34C12N2501/165C12N2501/115C12N2502/1311C12N2502/28
Inventor 周苗荣琼李树祎周杨刘尚彬吴晚秋卢冠杰
Owner STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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