Compositions, devices and methods for treating autism

一种自闭症、药物的技术，应用在药理学和微生物学,医学和胃肠学领域，能够解决细菌过度感染难检测出来等问题

Inactive Publication Date: 2020-03-31
托马斯·朱利叶斯·波洛迪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Some conditions are characterized clinically by fecal overinfection, but bacterial overinfection is difficult to detect, making treatment medically challenging

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] A 14-year-old autistic child (averbal) with OCD and severe abdominal pain, bloating, and constipation was started on rifaximin 500 mg bid and metronidazole 200 bid and later increased to 400 bid for gastrointestinal symptoms. His bowel symptoms gradually improved, though not completely, and vancomycin 250 mg bid was added. Over the next 6 months, his abdominal symptoms completely disappeared and he could sleep through the night without being woken up by the pain. About 9 months into his ongoing treatment, the parents reported via Skype consultation in the presence of his two caregivers that the boy is now in school, speaks more than 800 words, and follows orders. During the consultation, the child was asked to go to the garage and retrieve his father's coat, which was in the back seat of the car. The child quickly carried out the request. He continues to take oral medication and attend school.

Embodiment 2

[0147] A 22-year-old male with autism who cannot utter more than 2 words (mom and "no") was brought to treatment mainly because of his aggressive behavior (requiring two paramedics to keep him in office) and self-harming OCD. He banged his head against a brick wall until the scalp was cut so deep that the bone was visible and bled. He was scheduled to receive tinidazole 500 mg bid, rifaximin 500 mg bid 2 weeks later increasing to 1 g bid, and vancomycin 250 mg II bid. Over the next 6 months, the patient gradually lost her aggression, was able to sit and watch movies, and gradually lost most of her OCD symptoms, especially chewing on a large rubber "snake" toy. Over the next 6 months, the patient learned to say 3 words. Given the marked improvement in his behavior and language development, he continued his medication.

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PUM

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Abstract

The present invention relates to a method for treating, ameliorating, reversing and / or preventing autism or an autism spectrum disorder (ASD) via the administration of a formulation, a pharmaceuticalpreparation or a pharmaceutical composition comprising or consisting of: (a) a rifaximin (optionally a XIFAXAN, XIFAXANTA or NORMIXT), an extended intestinal release (EIR) rifaximin, a rifamycin derivative, a rifampicin (or rifampin) (optionally RIFADIN), a rifabutin (optionally MYCOBUTIN), a rifapentine (optionally PRIFTIN), a rifalazil, a bicozamycin, or a mixture or combination thereof, or (b)a rifaximin (optionally a XIFAXAN, XIFAXANTA or NORMIX) and at least one additional antimicrobial or antibiotic agent, wherein optionally the at least one additional antimicrobial or antibiotic agentcomprises a vancomycin, a metronidazole (optionally FLAGYLTM, METROTM), a tinidazole (optionally FASIGYN, SIMPLOTAN, TINDAMAX) or a combination thereof

Description

technical field [0001] The present invention relates generally to medicine and gastroenterology, pharmacology and microbiology. In alternative embodiments, pharmaceutical compositions and methods for treating, ameliorating, reversing and / or preventing (as a prophylaxis) autism or autism spectrum disorder (ASD), e.g., degenerative autism disease. In alternative embodiments, the pharmaceutical compositions and methods are administered and administered to children in need thereof. In alternative embodiments, the pharmaceutical compositions and methods are administered, formulated and administered in the form of solid, liquid or aerosol formulations or formulations. In alternative embodiments, the pharmaceutical composition includes rifaximin as the sole antibiotic, or rifaximin and other antimicrobial or antibiotic agents, such as vancomycin, metronidazole, tinidazole, or combinations thereof. Background technique [0002] Some conditions are characterized clinically by feca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61K31/496A61K31/454A61K31/495
CPCA61K38/14A61K31/4164A61K31/437A61P25/00A61K45/06A61K9/10A61K9/06A61K9/2004A61K9/4841A61K9/0056A61K9/2846A61K9/4891A61K9/19A61K9/0053A61K2300/00A61K31/357
Inventor 托马斯·朱利叶斯·波洛迪
Owner 托马斯·朱利叶斯·波洛迪
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