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Device and method for preparing gel microsphere and gel microsphere in which antitubercular agents can be injected

A technique for preparing gel microspheres and devices, which is applied in the direction of making drugs into special physical or ingestible devices, antibacterial drugs, and block delivery, etc., and can solve the complicated manufacturing process of anti-tuberculosis drug calcium alginate microspheres , Affect the production speed and quality of normal gel microspheres, hinder the droplet from contacting the gel solidification liquid, etc., achieve the effects of shortening the residence time, good atomization effect, and improving production speed and quality

Inactive Publication Date: 2014-03-05
中国人民解放军第三0九医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unacceptable as a slow-release carrier for injectable drugs. Many rifampicin drugs dissolve from calcium alginate microspheres when the microspheres are prepared by the dripping method, and enter into the gel solidification solution, which directly leads to the loss of rifampicin drugs. The encapsulation rate is reduced and the production cost is increased
In addition, the relative density of the drug-loaded calcium alginate microspheres prepared by the above method is less than 1.01, which is lower than the density of the gel solidification liquid, and the rifampicin-sodium alginate microspheres produced float on the surface of the gel solidification liquid, hindering the subsequent falling. The droplets contact the gel solidification liquid, and then adhere to the subsequent small droplets to form a line or floc, which seriously affects the production speed and quality of normal gel microspheres
The above technical data also suggest that the production process of the anti-tuberculosis drug calcium alginate microspheres is relatively complicated, the encapsulation rate of the drug is low and the sustained release time of the drug is not long enough

Method used

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  • Device and method for preparing gel microsphere and gel microsphere in which antitubercular agents can be injected

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] figure 1 Shown is a schematic structural diagram of a preferred embodiment of the gel microsphere preparation device of the present invention, the device includes: a porous nozzle 1, a collection cup 2, a collection pipe 3, a high-voltage electrostatic generator 9, a constant-flow pump 7, and a settling tank 4. Syringe pump 8 and infiltration electrode 5.

[0044] The upper part of the multi-hole spray head 1 has a liquid inlet, which is connected to the output end of the syringe pump 8, and the input end of the syringe pump 8 is connected to the drug-loaded sol storage device. The lower part of the porous nozzle has 12 nozzles 6 arranged in a ring. The nozzle 6 is a slender needle with a length of 6 cm to 20 cm. The inner diameter of the tip is 200 μm to 800 μm. The distance between the gel solidified liquid surface in the collection cup is 15mm to 60mm. There is a cavity in the porous nozzle 1, and a ring-shaped metal sheet is set in the cavity as the wetting electr...

Embodiment 2

[0063] Using the device and steps described in Example 1, changing the production formula and conditions, small particle size rifapentine gel microspheres can be obtained, and the specific process is as follows:

[0064] (1) Weigh 1.0g of rifapentine powder and 1.0g of stearic acid, dissolve in 8ml of ethyl acetate solvent at 50°C to obtain rifapentine stearic acid solution; weigh 1.8g of sodium alginate, dissolve In 90ml of distilled water, a 2.0wt% sodium alginate solution was obtained. The above rifapentine stearic acid solution was mixed with sodium alginate solution, and ultrasonically emulsified for 1 min to obtain rifapentine sol.

[0065] (2) Weigh 50 g of anhydrous calcium chloride, dissolve it in 2000 ml of distilled water, and prepare a 2.5 wt % calcium chloride solution to obtain a gel solidification solution.

[0066] (3) Put the rifapentine sol solution into the syringe pump. Set the voltage of the high-voltage electrostatic generator to 10000V, the inner diame...

Embodiment 3

[0072] Adopt the device described in embodiment 1 and similar steps, make rifabutin gel microsphere, concrete process is as follows:

[0073] (1) Weigh 2.5g of rifabutin powder and 2.5g of stearic acid, dissolve in 9.0ml ethyl acetate solvent at 50°C to obtain rifabutin stearic acid liquid; weigh 2.4g of sodium alginate, dissolve in 85ml of distilled water to obtain a 2.8wt% sodium alginate solution. The above rifabutin stearic acid solution and sodium alginate solution were heated to 60° C. and mixed to obtain rifabutin sol.

[0074] (2) Weigh 20 g of anhydrous calcium chloride, dissolve it in 2000 ml of distilled water, and prepare a 1 wt % calcium chloride solution to obtain a gel solidification solution.

[0075] (3) Fill the rifabutin sol into a syringe as a syringe pump. Set the voltage of the high-voltage electrostatic generator to 6000V, the inner diameter of the nozzle needle to 0.4mm, the distance between the tip of the nozzle needle and the surface of the gel soli...

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Abstract

The invention relates to a device and a method for preparing a gel microsphere and a gel microsphere in which antitubercular agents can be injected. The device comprises: a porous shower nozzle, a collecting cup, a collecting tubule, a high pressure static generator, a constant current pump, a settling basin, an injection pump and an infiltration electrode. On the basis of a common static liquid drop generating device, the collecting tubule is arranged to form a liquid level flow regulating system, so that a liquid exchange passage exists between the collecting cup and the settling basin and can collect the low-density gel microspheres floating on the liquid level of the collecting cup and rapidly transfer the microspheres to the settling basin. Meanwhile, the built-in infiltration electrode type porous shower nozzle can enable the drug liquid droplet in drug-carrying sol solution to be fully charged, and form a uniform high electric field with the collecting tubule, thus enhancing the atomizing effect of the liquid column of the nozzle and enabling the drug-carrying sol solution to form monodispersity gel microspheres. The gel microsphere in which antitubercular agents can be injected contains rifapentine or rifabutin, made by the device and the method. The gel microsphere is high in yield, and large in drug-carrying capacity, and does not sink down or adhere after drying.

Description

technical field [0001] The invention relates to a gel microsphere preparation technology, in particular to a low-density gel microsphere, a preparation method and a device thereof. Background technique [0002] The treatment of tuberculosis is mainly to inhibit and kill the parasitic Mycobacterium tuberculosis in cells through drugs. Commonly used drugs are rifapentine, rifampicin, and isoniazid. The first two are lipophilic drugs that are insoluble in water and easily penetrate biomembranes. However, direct oral administration is generally adopted. Rifapentine and rifampicin lipophilic drugs are less dissolved in body fluids, and the bioavailability of the drugs is not high. function causing major damage. For clinical anti-tuberculosis drug shock therapy, excessive doses in a short period of time will cause serious toxic and side effects to the body, and during the interval between each treatment, the blood elimination half-life of anti-tuberculosis drugs is less than 6 h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/06A61K9/16A61K31/496A61K31/454A61K47/36A61P31/06
Inventor 张广宇黎立杨楠史迎昌
Owner 中国人民解放军第三0九医院
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