Administration of antibiotic compounds for treatment of streptococcal infections for treatment of psoriasis

A streptococcus, antibiotic technology, applied in the fields of medicine, pharmacology and microbiology, can solve the problem of psoriasis without cure

Pending Publication Date: 2019-09-13
CENT FOR DIGESTIVE DISEASES PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Psorias...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] Example 1: Exemplary treatment of psoriasis in adults with OCD using metronidazole

[0198] A twenty-three-year-old patient with obsessive-compulsive personality disorder (OCD) was started in April 2016 on two nonabsorbable antibiotics (vancomycin and rifaximin) and absorbable metronidazole. The goal is to suppress his gut bacteria to reduce OCD. His scalp also had extensive psoriasis and dandruff-like scales.

[0199] Gradually, his behavioral changes were significantly suppressed, and his diarrhea and cramping and other accompanying symptoms were significantly improved. By November 2016, it was observed that metronidazole resulted in significant suppression of scalp psoriasis. By February 2017, little psoriasis remained on the scalp, and the OCD had improved, eg, the patient was less aggressive and more stable. This is an example of monotherapy using metronidazole to treat (eg suppress) psoriasis.

Embodiment 2

[0200] Example 2: Exemplary treatment of psoriasis with vancomycin and ceftriaxone

[0201] A 57-year-old patient with fairly extensive psoriasis of the back, buttocks, arms, and legs developed acute meningitis with neck stiffness, high fever, depth sensitivity, nausea, and vomiting. He was admitted in July 2011 and underwent baseline blood work, but unfortunately, he was treated with antibiotics before arriving at Teach Hospital, and even the lumbar puncture fluid did not grow the pathogen.

[0202] However, IV vancomycin is started along with IV ceftriaxone. Both antibiotics were given over four weeks, and while his fever stabilized, his pain and pain gradually improved. After being discharged from the hospital, he noticed that the massive psoriasis had completely disappeared. Over the next two and a half years, the psoriasis did not recur.

Embodiment 3

[0203] Example 3: Exemplary treatment of psoriasis with rifabutin, clofazimine and clarithromycin.

[0204] A patient with Crohn's disease and extensive psoriasis of the elbows, hands, knees, ankles, back, and buttocks started treatment for Mycobacterium avium paratuberculosis in January 2011, starting with oral rifabutin, clofazimine, and Clarithromycin started. He was told that his psoriasis was likely to improve very well, especially since clofazimine is known to suppress this and rifabutin has anti-inflammatory properties. The drug dose was gradually increased to reach 600mg / d rifabutin, 150mg / d clofazimine and 1g / d clarithromycin by the 6th week. It was noticed that not only was his inflammatory bowel disease slowly improving, but his rather extensive psoriasis was gradually disappearing, with new skin forming and the outer layer peeling off. He underwent three years of treatment. The psoriasis disappeared completely, and only 2 years after stopping the antibiotics, ...

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PUM

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Abstract

The present invention relates to the treatment of Streptococcal infections for the treatment of psoriasis via the administration of the antibiotic compounds vancomycin, rifamixin, metronidazole, ceftriaxone, rifabutin, clofazimine, clarithromycin, etanercept, rifampicin, or tinidazole, and combinations thereof.

Description

technical field [0001] The invention generally relates to medicine, pharmacology and microbiology. In alternative embodiments, compositions comprising therapeutic combinations of drugs are provided, and methods of using them, for example, to treat, ameliorate and prevent various bacterially induced conditions, disorders and infections in mammals, including genetic predispositions and chronic conditions. In alternative embodiments, methods using therapeutic combinations of drugs as provided herein (eg, antibiotics) are used to treat, ameliorate, inhibit or prevent a bacterially induced condition, disorder or infection in a mammal. Therapeutic combinations of these drugs, including drugs, formulations and medicaments, are effective in a broad spectrum of diseases including, for example, skin or skin-related autoimmune diseases or conditions, such as psoriasis. Background technique [0002] Psoriasis is an autoimmune disease characterized by abnormal skin patches that can rang...

Claims

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Application Information

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IPC IPC(8): A61K31/437A61K31/454A61K31/4164A61K31/496A61K38/14A61P17/06
CPCA61K31/498A61K31/546A61K31/424A61K31/435A61K31/438A61K31/437A61K38/13A61K31/538A61K31/43A61K31/7048A61K31/4164A61K31/395A61K38/1793A61K38/14A61K35/741A61K31/496A61K9/0019A61P31/04A61P17/06A61K2300/00C07K2319/30C07K2319/32A23L33/10A23V2002/00A61K2035/115
Inventor 托马斯·朱利叶斯·波洛迪
Owner CENT FOR DIGESTIVE DISEASES PTY LTD
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