Acinetobacter baumannii omp22 recombinant multi-antigen epitope polypeptide and its application

A technology of Acinetobacter baumannii and epitope polypeptide, applied in A.bOmp22 recombinant multi-antigen epitope polypeptide and application field, can solve problems such as toxicity and harm, and achieve the effect of avoiding toxic effect, reducing infection and epidemic
CN110950939BActive Publication Date: 2022-05-17THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
Publication Date
2022-05-17

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Abstract

The present invention belongs to the application of Acinetobacter baumannii Omp22; specifically relates to Acinetobacter baumannii Omp22 recombinant multi-antigen epitope polypeptide and its application; A.b The highly conserved and highly immunogenic Omp22 protein was used as the target antigen, and the dominant B cell epitopes and T cell epitopes of Omp22 protein were screened by bioinformatics and immunology methods, and each dominant antigenic epitope was identified by 6-aminocaproic acid. The polypeptides are connected in series, and the recombinant multi-antigen epitope polypeptide rOmp22 is chemically synthesized, which not only retains A.b Omp22 protein immunogenicity, and avoid the virulence of the original structural protein, to develop a safe and effective anti- A.b New vaccines for bacterial infections, to reduce A.b Infection and prevalence in hospitals provides a new tool. Animal experiments show that the recombinant vaccine can induce significant cellular and humoral immune responses in the body, has immune protection against Acinetobacter baumannii infection, and is highly safe and convenient to use.
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Description

technical field

[0001] The invention belongs to the application of the outer membrane protein Omp22 of Acinetobacter baumannii, in particular to a method for treating Acinetobacter baumannii ( Acinetobacter baumannii, A.b. ) infection with immunoprotective effect A.b Omp22 recombinant multi-antigen epitope polypeptide and its application. Background technique

[0002] Acinetobacter baumannii ( Acinetobacter baumannii, A.b. ) is a non-fermenting gram-negative bacillus, which is an opportunistic pathogen. It is widely distributed in the hospital environment and can survive for a long time. It can cause infections in the respiratory system, digestive system, urinary system, and central system, and even bloodstream infections. Morbidity and mortality And the drug resistance rate is in the forefront of Gram-negative bacilli infection. A.b The mechanism of drug resistance is complex, including the generation of various inactivated enzymes, the loss of outer membrane proteins,...

Claims

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