Flavone chromium and its producing method and use

A production method and technology of flavonoid chromium, applied in the field of flavonoid chromium and its production and application, can solve the problems such as the difficulty of inorganic chromium, achieve low cost, improve sensitivity, prevent and treat diabetes

Inactive Publication Date: 2003-05-28
宁夏百信生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inorganic chromium is not easy to be absorbed by the human body, and the aforementioned several existing organic chromium compounds, in addition to simple chromium supplementation, can only increase some nutrients such as vitamins and proteins
Plants contain a lot of flavonoi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example one:

[0028] The flavonoid chromium is a complex formed by flavonoids and trivalent chromium, and its molecular formula is RCrOH, where R is a large class of natural compounds with the following structural formula:

[0029] The flavonoid compound is rutin, and the molecular formula of the flavonoid chromium formed with trivalent chromium is: (C 27 O 16 H 31 )CrOH, the reaction equation is:

[0030]

[0031] The production method of the flavonoid chromium consists of the following specific steps:

[0032] (1) Put rutin and methanol into the reactor at a ratio of 1:40 (w / v);

[0033] (2) Add chromium trichloride in the ratio of 1:1 molar ratio of rutin to chromium, heat to dissolve, heat to react at 60-80℃, and slowly add methanol ammonia, the color of the solution is from green to yellow -The brown sequence changes. When the pH of the solution is 6, the color will be dark brown. The reaction is refluxed for 0.5 hours. When methanol and ammonia are continuously...

Example Embodiment

[0035] Embodiment two:

[0036] The flavonoid chromium is a complex formed by flavonoids in licorice and trivalent chromium, and its molecular formula is RCrOH, where R is a licorice flavonoid with the following structural formula:

[0037] The production method of the flavonoid chromium consists of the following specific steps:

[0038] (1) Put licorice flavonoids and methanol into the reactor at a ratio of 1:40 (w / v);

[0039] (2) Add chromium trichloride in the molar ratio of licorice flavonoids to chromium 1:1, heat to dissolve, heat to react at 60-80℃, and slowly add methanol ammonia, the color of the solution is from green to yellow -The brown sequence changes. When the pH of the solution is 6, the color will be dark brown. The reaction is refluxed for 0.5 hours. When methanol and ammonia are continuously added dropwise, a large amount of precipitation is formed. When the pH of the solution is 7.5, the precipitation is complete. It is called chromium flavone, named chromium...

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PUM

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Abstract

Flavone compound and chromium compound are made to react to produce flavone chromium. Flavone chromium, unlike inorganic chromium compound being not easy to be absorbed by human body, has the comprehensive curative effect of both flavone and chromium compound and can promote and raise the sensitivity of insulin, soften and dilate blood vessel, improve microcirculation, regulate metabolism, prevent and cure diabetes, hyperlipomia, hypertension, and other diseases.

Description

technical field [0001] The invention relates to a flavonoid chromium and its production method and application. Background technique [0002] Chromium is an essential trace element for the human body. The organic compounds of chromium that can be seen include chromium gluconate, yeast chromium, chromium sodium chlorophyllinate and chromium picolinate. Trivalent chromium forms glucose tolerance factor in the body and promotes glucose metabolism. Chromium deficiency in the human body can disturb glucose metabolism, leading to abnormal glucose tolerance and diabetes. Inorganic chromium is not easily absorbed by the human body, and the aforementioned several existing organic chromium compounds can only increase nutrients such as vitamins and proteins in addition to simple chromium supplementation. Plants contain a lot of flavonoids, such as rutin, licorice flavonoids, etc. As a drug, it has pharmacological functions such as softening and dilating blood vessels, normalizing mic...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/00A61P3/06A61P3/10A61P9/10C07D311/28
Inventor 刘钢刘祎春李学强熊楚明
Owner 宁夏百信生物科技有限公司
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