Orally disintegrating tablet containing policosanol

An orally rapidly disintegrating tablet and policosanol technology, which is applied in the field of pharmaceutical preparations, can solve the problems of increasing the dissolution rate of policosanol and poor water solubility of policosanol, so as to solve the problems of poor water solubility, prolong shelf life, and increase dissolution degree of effect

Pending Publication Date: 2020-04-14
UNIV OF JINAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention can not only solve the problem of poor water solubility of policosanol, significantly increase the dissolution rate of policosanol, improve the bioavailability of policosanol; also solve the stability problem of liposomes

Method used

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  • Orally disintegrating tablet containing policosanol
  • Orally disintegrating tablet containing policosanol
  • Orally disintegrating tablet containing policosanol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepare 1000 tablets, each tablet contains 15 mg of policosanol, the amount of raw materials and auxiliary materials is: 15 parts of policosanol, 100 parts of egg yolk lecithin material, 200 parts of lactose, and 0.3 part of cyclamate. The preparation method steps are as follows:

[0035] (1) Preparation of policosanol liposomes:

[0036] Accurately weigh 15g of policosanol and 100g of egg yolk lecithin (the ratio of drug to lipid is 3:20) into 1L of ethanol solution, add magnets, and stir at 50°C for 40 minutes to completely dissolve the policosanol. And under stirring, the ethanol solution in which policosanol and phospholipids were dissolved was dropped dropwise into 19 L of distilled water with a syringe, and the ethanol and water were removed by rotary evaporation to obtain 1 L of liposome solution.

[0037] (2) Orally rapidly disintegrating tablet of policosanol liposome prepared:

[0038] Weigh other components according to the formula, add them to the above li...

Embodiment 2

[0040] Prepare 1000 tablets, each tablet contains 15 mg of policosanol, the amount of raw materials and auxiliary materials is: 10 parts of policosanol, 100 parts of soybean lecithin, 200 parts of lactose, and 0.3 part of sodium saccharin. The preparation process is the same as in Example 1.

Embodiment 3

[0042] Prepare 1000 tablets, each tablet contains 15 mg of policosanol, the amount of raw materials and auxiliary materials is: 10 parts of policosanol, 200 parts of cephalin, 200 parts of mannitol, and 0.3 part of aspartame. The preparation process is the same as in Example 1.

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Abstract

The invention discloses an orally disintegrating tablet containing policosanol. The tablet is composed of the following raw materials by weight: 1.5- 4.5 parts of policosanol, 15.0-30.0 parts of a lipid material, 30.0-60.0 parts of a freeze-drying protective agent and 0.1-0.5 part of a flavoring agent. Meanwhile, the invention also discloses a preparation method of the orally disintegrating tablet. The orally disintegrating tablet prepared according to the invention can be conveniently applied to elderly patients with dysphagia and poor compliance, at the same time, the drug is released quickly, so that the bioavailability of the drug is improved. The drug exists in the preparation in a liposome form, so that the drug solubility can be increased, the drug storage life is prolonged, and theeffect of covering bad taste of the drug is also achieved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to an orally rapidly disintegrating tablet containing policosanol. Background technique [0002] Policosanol is a lipid-lowering botanical drug extracted from sugarcane that replaces statins and has no side effects. It is produced and sold in my country by Shanchuan Pharmaceutical from Cuba. Nonclinical models suggest that policosanol acts by inhibiting cholesterol biosynthesis. In addition, this product can also promote the catabolism of low-density lipoprotein cholesterol (LDL-C) by increasing the binding and internalization process of low-density lipoprotein (LDL) to receptors, thereby reducing the level of LDL-C in plasma. At the same time, this product can also increase high-density lipoprotein cholesterol (HDL-C) levels, reduce triglycerides and very low-density lipoprotein cholesterol (VLDL-C) levels. At the same time, this product also has the effects o...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/24A61K47/26A61K31/045A61P3/06A61P9/00
CPCA61K9/0056A61K9/2013A61K9/2018A61K31/045A61P3/06A61P9/00
Inventor 王凯铭赵忠熙苏雨菲余金凤
Owner UNIV OF JINAN
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