Multifunctional nano-cluster and preparation method thereof

A nano-cluster, multi-functional technology, applied in the field of multi-functional nano-cluster and its preparation, can solve the problems of weakening magnetic properties, cumbersome operation, oxidation and iron content reduction, etc. Effect

Inactive Publication Date: 2020-04-17
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods usually contain many steps, the operation is cumbersome, and the multi-step modification process may cause Fe 3 o 4 Oxidation and reduction of iron content eventually lead to weakened magnetic properties

Method used

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  • Multifunctional nano-cluster and preparation method thereof
  • Multifunctional nano-cluster and preparation method thereof
  • Multifunctional nano-cluster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Multifunctional nanocluster of the present invention (Fe 3 o 4 @F127@FA) is prepared as follows:

[0046] Step 1, weigh 10mg oil-soluble Fe 3 o 4 Nanoparticles were dissolved in 10mL cyclohexane to obtain solution A; in addition, 5 mg of folic acid-targeted modified triblock copolymer polyoxyethylene-polyoxypropylene-polyoxyethylene (F127)@FA was dissolved in 10mL water to obtain Solution B;

[0047] Step 2, mix solution A and solution B, put it on an ice bath for ultrasonic treatment, the ultrasonic treatment power is 40W, and the time is 30min;

[0048] Step 3, after ultrasonic treatment, let stand for 12 hours, extract and collect the aqueous phase of the solution after the solution is layered;

[0049] Step 4, after the sample in the aqueous phase of the solution is obtained by magnetic separation, it is washed with water multiple times to obtain the multifunctional nanocluster for targeted drug delivery and magnetic resonance imaging.

[0050] Oil-soluble Fe ...

Embodiment 2

[0063] Multifunctional nanocluster of the present invention (Fe 3 o 4 @F127@FA) is prepared as follows:

[0064] Step 1, weigh 10mg oil-soluble Fe 3 o 4 Nanoparticles were dissolved in 10mL cyclohexane to obtain solution A; in addition, 10mg of folic acid-targeted modified block copolymer polyoxyethylene-polyoxypropylene-polyoxyethylene (F127@FA) was dissolved in 10mL water to obtain a solution B;

[0065] Step 2, mix solution A and solution B, place on ice bath for ultrasonic treatment, ultrasonic treatment power 40W, ultrasonic treatment 2s, interval 3s, total time 50min;

[0066] Step 3, after ultrasonic treatment, let it stand overnight, extract and collect the aqueous phase of the solution after the solution is layered;

[0067] Step 4, after the sample in the aqueous phase of the solution is obtained by magnetic separation, it is washed with water multiple times to obtain the multifunctional nanocluster for targeted drug delivery and magnetic resonance imaging.

[...

Embodiment 3

[0072] Multifunctional nanocluster of the present invention (Fe 3 o 4 @F127@FA) is prepared as follows:

[0073] Step 1, weigh 5mg oil-soluble Fe 3 o 4 Nanoparticles were dissolved in 10mL cyclohexane to obtain solution A; in addition, 5mg of folic acid-targeted modified block copolymer polyoxyethylene-polyoxypropylene-polyoxyethylene (F127@FA) was dissolved in 10mL water to obtain a solution B;

[0074] Step 2, mix solution A and solution B, place on ice bath for ultrasonic treatment, ultrasonic treatment power 40W, ultrasonic treatment 2s, interval 3s, total time 50min;

[0075] Step 3, after ultrasonic treatment, let it stand overnight, extract and collect the aqueous phase of the solution after the solution is layered;

[0076] Step 4, after the sample in the aqueous phase of the solution is obtained by magnetic separation, it is washed with water multiple times to obtain the multifunctional nanocluster for targeted drug delivery and magnetic resonance imaging.

[00...

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Abstract

The invention relates to a multifunctional nano-cluster for targeted drug delivery and magnetic resonance radiography and a preparation method thereof. The preparation method comprises the following steps: step 1, weighing a proper number of oil-soluble Fe3O4 nanoparticles, and dissolving the oil-soluble Fe3O4 nanoparticles in an organic solvent to obtain a solution A; in addition, weighing a proper amount of folic-acid targeting modified block copolymer polyoxyethylene-polyoxypropylene-polyoxyethylene (F127@FA), and dissolving the folic-acid targeting modified block copolymer polyoxyethylene-polyoxypropylene-polyoxyethylene (F127@FA) in water to obtain a solution B; step 2, mixing the solution A and the solution B, and placing the mixture on an ice bath for ultrasonic treatment; step 3, performing standing after ultrasonic treatment, performing extracting after layering of the solution, and collecting a solution water phase; and step 4, acquiring a sample in the aqueous phase of the solution by adopting a centrifugal or magnetic separation mode, so as to obtain a multifunctional nano-cluster for targeted drug delivery and magnetic resonance radiography. The preparation method is simple, and the prepared magnetic nano material is good in magnetic responsiveness and biocompatibility.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, and in particular relates to a multifunctional nano-cluster for targeted drug delivery and magnetic resonance imaging and a preparation method thereof. Background technique [0002] Multifunctional nanomaterials have gained widespread attention in the field of biomedicine, such as functional nanomaterials with fluorescence imaging and drug delivery, and functional nanomaterials with magnetic resonance imaging and drug delivery in the early diagnosis and treatment of tumors. has great advantages. [0003] In recent years, magnetic nanomaterials have been widely used in biomedical fields such as targeted drug delivery, cell analysis, and early diagnosis of tumors because of their unique magnetic responsiveness and biocompatibility. Among them, superparamagnetic Fe3O4 nanoparticles (Fe 3 o 4 ) is the only material approved by the U.S. Food and Drug Administration (FDA) among many magnetic material...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12A61K9/51A61K47/22A61K47/10A61K31/704A61P35/00
CPCA61K9/5123A61K9/5146A61K31/704A61K49/126A61K49/1857A61P35/00
Inventor 宋梦梦陈静张贵阳刘睿
Owner ANHUI MEDICAL UNIV
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