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A kind of sensitizer for radiotherapy and its preparation method and application

A sensitizer and tumor radiotherapy technology, which is applied in the fields of nanomaterial chemistry and biochemistry, can solve the problems of radiosensitizers failing to improve the hypoxic state of tumor microenvironment, large amount of radioactive agent, and large tissue damage. and promotion, reducing dosage and reducing damage

Active Publication Date: 2022-06-07
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the above analysis, the present invention aims to provide a sensitizer for radiotherapy and its preparation method and application to solve the problem that existing radiotherapy sensitizers cannot improve the hypoxic state in the tumor microenvironment, radiotherapy is not sensitive, The amount of radiation dose is large and the problem of large damage to normal tissues

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  • A kind of sensitizer for radiotherapy and its preparation method and application
  • A kind of sensitizer for radiotherapy and its preparation method and application
  • A kind of sensitizer for radiotherapy and its preparation method and application

Examples

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Embodiment 1

[0046] A specific embodiment of the present invention discloses a sensitizer for radiotherapy, and the molecular formula of the sensitizer is BiO 2-x , the molecular structure has oxygen defects, and the raw materials for the preparation of sensitizers include alkali metal hydroxides and bismuthates.

[0047] Compared with the prior art, on the one hand, the sensitizer provided by the present embodiment has oxygen defects in its molecular structure, and the bismuth oxide containing oxygen defects can efficiently catalyze hydrogen peroxide to generate oxygen, and has an effect similar to catalase, The oxygen generated by catalysis can improve tumor hypoxia and improve the sensitivity of tumor radiotherapy, thereby reducing the dosage of radiotherapy agents, thereby reducing the damage to normal tissues, and achieving a very good inhibitory effect on tumors at lower radiation doses. On the other hand, by selecting metal bismuth with a specific atomic number, it has a very good a...

Embodiment 2

[0053] Another embodiment of the present invention discloses a method for preparing a sensitizer, which is used to prepare the sensitizer for radiotherapy of Example 1, comprising the following steps:

[0054] Step 1: Disperse 0.8-1.2 g of alkali metal hydroxide and 1 g of bismuth salt in deionized water, and stir to obtain a solution;

[0055] Step 2: transfer the solution to the reaction vessel, heat to 160~200℃, and react for 4~10h;

[0056] Step 3: Cool to room temperature, wash with deionized water, and dry at 60-100°C for 2-8 hours to obtain BiO 2-x .

[0057] It should be noted that in step 2, the reaction time should not be too long, because if the time is too long, many by-products, such as other oxidized products of bismuth, will be generated, which will affect the sensitivity to tumor radiotherapy; while the reaction time is too short, it will lead to reaction incomplete. The reaction time is controlled to be 4 to 10h, and the reaction temperature is controlled t...

Embodiment 3

[0065] (1) Take 0.5g NaOH and 1g NaBiO 3 Disperse in 15mL deionized water, stir for 2 hours to disperse evenly;

[0066] (2) Transfer the well-stirred solution to a 50 mL hydrothermal kettle, and react at 160° C. for 10 hours. After cooling to room temperature, wash with deionized water for 5 times and bake at 60°C for 8 hours;

[0067] (3) 400mg BiO 2-x Dissolve in 16mL of water and 16mL of ethanol, then add 16μL of Tween-20 (Tween-20) to obtain a mixed solution;

[0068] (4) ultrasonication (300W) of the mixed solution in an ultrasonic tank for 30 minutes;

[0069] (5) use an ultrasonic cell disruptor to break for 12 hours, take out after the breaking is completed, cover with a parafilm and let stand for one night, remove the material precipitated at the bottom, and take the uniformly dispersed solution on the upper layer;

[0070] (6) Centrifuge at 12,000 rpm for 5 minutes, continue to wash with deionized water three times, and then freeze-dry it for later use.

[0071...

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Abstract

The invention relates to a sensitizer for radiotherapy and its preparation method and application, belonging to the field of nanomaterial chemistry and biochemistry, and solves the problem that the existing radiotherapy sensitizer cannot improve the hypoxic state in the tumor microenvironment, and radiotherapy is not sensitive , The amount of radiation dose is large, and the problem of large damage to normal tissues. The molecular formula of the sensitizer used in radiotherapy is BiO 2‑x , there are oxygen defects in the molecular structure, and the raw materials for the preparation of the sensitizer include alkali metal hydroxides and bismuth salts. The preparation method of the sensitizer comprises: dissolving alkali metal hydroxide and bismuth salt, stirring to obtain a solution; transferring the solution to a reaction container, heating, and reacting for a period of time. BiO of the present invention 2‑x It can be used as a sensitizer for radiosensitization of tumors, and achieves a very good inhibitory effect on tumors at a lower radiation dose.

Description

technical field [0001] The invention relates to the technical fields of nanomaterial chemistry and biochemistry, in particular to a sensitizer for radiotherapy and a preparation method and application thereof. Background technique [0002] The incidence of malignant tumors in the world is increasing year by year, and the mortality rate has remained high, which seriously threatens the survival and health of human beings. Radiation therapy, as a non-invasive tumor treatment method, is widely used in the treatment of different types of tumors. In tumor radiotherapy, after tumor cells absorb a certain amount of radiation energy, radiation can directly interact with intracellular biological macromolecules to generate free radicals, causing DNA molecules to break and crosslink; radiation can also cause ionization of water molecules in tissues to generate free radicals , these free radicals interact with biological macromolecules to cause cell damage and death, thereby achieving t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/26A61P35/00C01G29/00
CPCA61P35/00C01G29/00A61K41/0038A61K33/245A61K47/549B82Y5/00C01P2004/04C01P2002/72C01P2002/85C01P2002/82
Inventor 谷战军董兴华刘慧敏赵宇亮
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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