Application of lactobacillus acidipiscis for preparing medicine capable of preventing or treating autoimmune diseases

An autoimmune and lactobacillus technology, applied in the direction of allergic diseases, metabolic diseases, bone diseases, etc., can solve the problems of toxic and side effects of patients, and achieve the effect of solving recurrence, mature amplification technology and easy to accept
CN111084792AInactive Publication Date: 2020-05-01STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
Publication Date
2020-05-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of lactobacillus acidipiscis for preparing a medicine capable of preventing and / or treating autoimmune diseases. The invention firstly provides the lactobacillus acidipiscis, Treg cell differentiation is obviously accelerated, TH1 cell or TH17 cell differentiation is inhibited, the generation of cell factors IFN (interferon)-[gamma] or IL-17 (interleukin 17) isinhibited, the generation of cell factors IL-10 or IL-13 is accelerated, and the inflammatory reaction of the autoimmune diseases is obviously reduced. The invention also provides a medicine for treating the autoimmune diseases. The medicine comprises an effective dosage of lactobacillus acidipiscis. After a patient takes the medicine, an obvious effect for treating the autoimmune diseases is achieved, no toxic and side effects are generated, and in addition, the lactobacillus acidipiscis can be conveniently obtained. Therefore, the lactobacillus acidipiscis has a wide application prospect inthe medicine capable of treating the autoimmune diseases.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of Lactobacillus acidicus in the preparation of medicines for preventing or treating autoimmune diseases. Background technique

[0002] Autoimmune disease (autoimmune disease, AID) refers to a type of disease induced by the body's immune system's immune tolerance to its own components being broken, thereby attacking its own organs, tissues or cells, causing damage; for example, multiple sclerosis , Graves' disease, autoimmune liver disease, type I diabetes, systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, etc. Abnormalities in the number and / or function of T cells play a crucial role in the pathogenesis of autoimmune diseases, among which regulatory T cells (Regulatory cells, Tregs) are a kind of T cell subsets that control autoimmune reactivity in the body. Treg group, which can inhibit their own inflammatory response,...

Claims

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