Biological patch and preparation method thereof
A bio-patch, sheet-like technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of lack of biological activity, erosion or scarring, and the interface between tendon and bone is not easy to heal, so as to improve the safety of use. , the effect of reducing immunogenicity, good cell removal effect
Active Publication Date: 2021-02-02
动之医学技术(上海)有限公司 +1
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Problems solved by technology
The success rate of traditional rotator cuff repair surgery is not high, and the postoperative tendon-bone interface is not easy to heal. Therefore, the development of medical patches for rotator cuff repair to promote the healing of rotator cuff tissue and improve the postoperative function of patients has become an important issue in recent years. to focus on
[0003] At present, most of the patches used for rotator cuff repair are mainly composed of polymer materials. Although the polymer materials used have certain biocompatibility, as inert materials, due to the lack of biological activity, it will inevitably make the human body Adverse reactions such as rejection, erosion or scarring
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[0027] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention are clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, and Not all examples. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention. Unless otherwise defined, the technical terms or scientific terms used herein shall have the usual meanings understood by those skilled in the art to which the present invention belongs. As used herein, "comprising" and similar words mean that the elements or items appearing before the word include the elements or items listed after the word and their equivalents, without excluding o...
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Abstract
The present invention provides a biological patch, which is a sheet mainly composed of acellular matrix. The acellular matrix is derived from the umbilical cord tissue from which vascular cells have been removed, the acellular matrix is mainly composed of the extracellular matrix of the umbilical cord tissue, and the extracellular matrix is rich in a variety of growth factors and has good biological activity, It can effectively recruit cells at the contact site and provide them with a suitable growth structure, induce cell directional differentiation, and thus facilitate the healing effect of rotator cuff tissue; Immunogenicity of biological patches to improve safety of use. The present invention also provides a preparation method of the biological patch.
Description
technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a biological patch and a preparation method thereof. Background technique [0002] Rotator cuff injuries are one of the most common tendon injuries in orthopedic surgery and are a common cause of shoulder pain, reduced mobility, or reduced function. The success rate of traditional rotator cuff repair surgery is not high, and the postoperative tendon-bone interface is not easy to heal. Therefore, the development of medical patches for rotator cuff repair to promote the healing of rotator cuff tissue and improve the postoperative function of patients has become an important issue in recent years. to focus on. [0003] At present, most of the patches used for rotator cuff repair are mainly composed of polymer materials. Although the polymer materials used have certain biocompatibility, as inert materials, due to the lack of biological activity, it will inevitably make ...
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IPC IPC(8): A61L27/36A61L27/50A61L27/56
CPCA61L27/3633A61L27/3691A61L27/3695A61L27/50A61L27/56A61L2430/10
Inventor 朱雪晶刘博武赵金忠王立人蒋佳
Owner 动之医学技术(上海)有限公司