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Application of porcine beta-defensin 2 peptide fragment to preparation of medicine composition for preventing and treating streptococcus suis infection

A technology of Streptococcus suis and defensin, which can be applied in antibacterial drugs, pharmaceutical formulations, peptide/protein components, etc.

Inactive Publication Date: 2020-05-15
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there have been no domestic and foreign reports on the use of artificially synthesized PBD-2 peptides in the preparation of pharmaceutical compositions for the prevention and treatment of Streptococcus suis

Method used

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  • Application of porcine beta-defensin 2 peptide fragment to preparation of medicine composition for preventing and treating streptococcus suis infection
  • Application of porcine beta-defensin 2 peptide fragment to preparation of medicine composition for preventing and treating streptococcus suis infection
  • Application of porcine beta-defensin 2 peptide fragment to preparation of medicine composition for preventing and treating streptococcus suis infection

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Embodiment Construction

[0022] Description of the sequence listing:

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Abstract

The invention belongs to the technical field of prevention and treatment of animal infectious diseases, and particularly relates to application of a PBD-2 (Porcine Beta-Defensin 2) peptide fragment topreparation of a medicine composition for preventing and treating streptococcus suis infection. The PBD-2 peptide fragment has no cytotoxicity in vitro and has an obvious inhibition effect on streptococcus suis growth. Through PBD-2 treatment, the mortality rate, the inflammatory cytokine level, the tissue bacterial load quantity and the pathology damage degree of mice infected with streptococcussuis can be obviously reduced. The invention provides basic candidate medicine for pharmaceutical application of the PBD-2 peptide fragment to preparation of medicine for preventing and treatment thestreptococcus suis infection.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of animal infectious diseases, and in particular relates to the application of porcine beta-defensin 2 (PBD-2) peptides in the preparation of pharmaceutical compositions for preventing and treating Streptococcus suis infection. The PBD-2 short peptide can inhibit the growth of Streptococcus suis in vitro, and can prevent and treat the infection of Streptococcus suis on animals. Background technique [0002] Suis streptococcosis is a kind of zoonotic acute febrile infectious disease caused by a variety of pathogenic streptococci, which has brought huge losses to the pig industry and seriously threatened human health. Streptococcus suis is a gram-positive bacterium that colonizes the tonsils and nasal cavity of pigs for a long time. The clinical symptoms of Streptococcus suis infection are affected by the age and serotype of pigs, and the main manifestations are lymph node abscess,...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P31/04
CPCA61K38/1729A61P31/04
Inventor 黎璐周锐王安田黄靖黄超宋炳晓孙瑜凡
Owner HUAZHONG AGRI UNIV
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