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Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to Anti-infectives based on redox reactions

A concentration and sensor technology, applied in biochemical equipment and methods, chemical instruments and methods, and microbial determination/inspection, etc., which can solve problems such as technical or clinician errors, complex instruments, and large testing equipment.

Active Publication Date: 2020-05-19
AVAILS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods require manual interpretation by skilled technicians and are prone to technical or clinician error
[0006] While automated inspection of such panels or media can reduce the likelihood of clinician error, the instruments currently used to perform these inspections are often complex and require the addition of reporter molecules or the use of expensive components such as transparent oxidized Indium tin (ITO) electrodes
Additionally, current instruments often rely on optical readout of the sample under study, which requires bulky detection equipment

Method used

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  • Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to Anti-infectives based on redox reactions
  • Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to Anti-infectives based on redox reactions
  • Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to Anti-infectives based on redox reactions

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Embodiment Construction

[0026] Variations of the devices, systems and methods described herein are best understood from the Detailed Description when taken in conjunction with the accompanying drawings. It is emphasized that, according to common practice, the various features of the drawings may not be drawn to scale. On the contrary, the dimensions of the various features may be arbitrarily expanded or reduced for clarity, and not all features may be seen or labeled in every drawing. The drawings are for illustrative purposes only, and are not intended to define or limit the scope of the claims to that shown.

[0027] figure 1 An embodiment of a method 100 for determining the concentration of one or more infectious agents 102 in a sample 104 is shown. Method 100 may include introducing one or more aliquots of sample 104 into one or more reaction vessels 106 . In Step 1A, the reaction vessel 106 may refer to one or more test tubes, reaction tubes, wells of a high-throughput assay plate or well pla...

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Abstract

Various methods, devices, and systems for determining the concentration of microorganisms in a sample and determining the susceptibility of such microorganisms to one or more antibiotics or other types of anti-infectives are disclosed herein. More specifically, methods for quantifying microorganisms based on redox reactions are disclosed along with systems and devices for quantifying such microorganisms using certain oxidation reduction potential (ORP) sensors. Moreover, methods for determining the susceptibility and the degree of susceptibility of microorganisms to one or more anti- infectives are disclosed along with multiplex systems for such assays.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 567,648, filed October 3, 2017, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates generally to the in vitro detection of microorganisms or infectious agents, and more particularly, to devices, systems and methods for determining the concentration of microorganisms or infectious agents and the susceptibility of such microorganisms or infectious agents to infectious agents. Background technique [0004] Infections caused by anti-infective resistant microorganisms or infectious agents are a significant problem for health care professionals in hospitals, nursing homes and other health care settings. Rapid detection of such microorganisms is crucial in order to prevent the expansion of their resistance profile. When confronted with such infections, it is preferred for the clinician to u...

Claims

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Application Information

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IPC IPC(8): B01L3/02C12Q1/04G01N1/38G01N15/06G01N33/569G01N35/10H01M4/04
CPCG01N15/06B01L3/502715B01L7/00B01L2200/143B01L2200/148B01L2300/023B01L2300/0636B01L2300/0645B01L2300/0819B01L2300/0864B01L2300/0867C12Q1/06C12Q1/18G01N2015/019G01N15/01G01N27/4168
Inventor 奥伦·S·克诺普夫马赫梅克·赫格特尼廷·K·拉赞迈克尔·D·劳弗尔
Owner AVAILS MEDICAL