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Long-acting disinfectant stabilized by synergistic agent

A disinfectant and stable technology, applied in the field of long-acting disinfectants, can solve the problems of danger, waste of resources, secondary pollution, etc., achieve good biological safety, enhance disinfection effect, and promote the effect of dispersion

Inactive Publication Date: 2020-06-09
SHANGHAI COACHCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chlorine dioxide is favored for its excellent disinfection performance, but the concentration of chlorine dioxide in the air will be dangerous if it exceeds a certain range, and there are unsafe factors in use and storage, which make its effectiveness not fully exerted, resulting in a waste of resources , may even cause secondary pollution
[0004] Although the above strategies can stabilize chlorine dioxide to a certain extent, the additives or stabilizers used will have certain biological safety or compatibility issues, and are not suitable for personal care / disinfection products, especially those with skin products used in direct contact with

Method used

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  • Long-acting disinfectant stabilized by synergistic agent
  • Long-acting disinfectant stabilized by synergistic agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Polyethylene Glycol Long Chain Alkylamine (Polyethylene Glycol 1000 Octadecylamine):

[0028]

[0029] Alkyl chain contains 18 carbon atoms, polyethylene glycol fragment molecular weight is the polyethylene glycol long-chain alkylamine preparation method of 1000: in the autoclave of 500ml, add the polyethylene glycol monomethyl ether of molecular weight 1000 ( mPEG1000) 100 grams (0.1mol), silicon dioxide 3 grams (0.05mol), aluminum oxide 10 grams (0.1mol), octadecylamine 27 grams (0.1mol), after reacting for 36 hours at 180 degrees Celsius, water and Extracted three times with ethyl acetate. The aqueous layer was removed, and the organic layer was dried over anhydrous sodium sulfate. Remove the solvent with a rotary evaporator, then extract the product with dichloromethane and evaporate the solvent to obtain 111 grams of polyethylene glycol octadecylamine (1), with a yield of 89%

Embodiment 2

[0031] Preparation of Polyethylene Glycol Long Chain Alkylamine (Polyethylene Glycol 500 Cetylamine):

[0032]

[0033] Alkyl chain contains 16 carbon atoms, polyethylene glycol segment molecular weight is the polyethylene glycol long-chain alkylamine preparation method of 500: in the autoclave of 500ml, add the polyethylene glycol monomethyl ether ( mPEG500) 50 grams (0.1mol), silicon dioxide 3 grams (0.05mol), aluminum oxide 10 grams (0.1mol), hexadecylamine 26 grams (0.1mol), after reacting for 36 hours at 180 degrees Celsius, water and Extracted three times with ethyl acetate. The aqueous layer was removed, and the organic layer was dried over anhydrous sodium sulfate. Remove the solvent with a rotary evaporator, then extract the product with dichloromethane and evaporate the solvent to obtain 65 grams of polyethylene glycol cetylamine (2), with a yield of 88%

Embodiment 3

[0034] Embodiment 3 (disinfectant formula 1)

[0035]

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Abstract

The present invention provides a long-acting disinfectant stabilized by a synergistic agent. The synergistic agent mainly comprises polyethylene glycol long-chain alkylamine, benzalkonium chloride, polyhexamethylene guanidine hydrochloride, quaternary ammonium salt-73 and the like. The benzalkonium chloride, polyhexamethylene guanidine hydrochloride and quaternary ammonium salt-73 have bactericidal ability and can react with chlorine dioxide to disperse charges on oxygen atoms of chlorine dioxide, so that the stabilizing effect on chlorine dioxide is achieved. The polyethylene glycol long-chain alkylamine can effectively wrap chlorine dioxide, benzalkonium chloride, polyhexamethylene guanidine hydrochloride, quaternary ammonium salt-73 and other active ingredients through the coordinationeffect of a plurality of oxygen atoms of the polyethylene glycol long-chain alkylamine, and long-chain alkyl fragments have an isolation effect, so that the degradation speed of the active ingredientsis reduced, and long-acting disinfection is realized.

Description

technical field [0001] The invention relates to the fields of daily chemicals, personal cleaning, personal care, disinfection and the like, especially a long-acting disinfectant stabilized by synergistic substances. The synergistic substances in this type of disinfectant can effectively delay the decomposition of chlorine dioxide, the main disinfection component, thereby enhancing the disinfection effect. Background technique [0002] Chlorine dioxide is favored for its excellent disinfection performance, but the concentration of chlorine dioxide in the air will be dangerous if it exceeds a certain range, and there are unsafe factors in use and storage, which make its effectiveness not fully exerted, resulting in a waste of resources , and may even cause secondary pollution. Therefore, synergists are added to the disinfectant formula to establish a controlled release chlorine dioxide model, so that the release rate of chlorine dioxide can be effectively controlled, that is,...

Claims

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Application Information

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IPC IPC(8): A01N59/00A01N47/44A01N43/78A01N33/12A01N33/08A01N25/30A01P1/00A01P3/00A61K33/20A61K31/785A61K31/427A61K31/14A61P31/00
CPCA01N25/30A01N33/08A01N33/12A01N43/78A01N47/44A01N59/00A61K31/14A61K31/427A61K31/785A61K33/20A61P31/00A61K2300/00
Inventor 吴江韦萍林渊张伟
Owner SHANGHAI COACHCHEM TECH
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