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Cell segmentation method, device and computer-readable storage medium

A cell and nucleus technology, applied in the field of image processing, can solve the problems of missed detection and false detection of cell segmentation methods, and achieve the effect of avoiding the problem of false detection and missed detection of cell nuclei

Active Publication Date: 2021-09-07
NORTH CHINA UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

[0010] In view of this, the embodiments of the present invention provide a cell segmentation method, device, and computer-readable storage medium to solve the problems existing in existing cell segmentation methods when the intensity distribution of image pixels is uneven and a large number of cell nuclei accumulate and overlap. The problem of detection and false detection

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  • Cell segmentation method, device and computer-readable storage medium

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Embodiment Construction

[0087] The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are only some of the embodiments of the application, not all of them. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without making creative efforts belong to the scope of protection of this application.

[0088]In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " The orientation or positional relationship indicated by "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation shown in the drawings Or positional relationship is only for the convenience of describing the present application and simplifying ...

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Abstract

The invention provides a cell division method, device and computer-readable storage medium. The method includes obtaining an original image; processing the original image to obtain an image I gray ;Using the local threshold method to image I gray processed to get the image I CLT ; Using the LoG algorithm to image I gray processed to get the image I LoG ; for image I CLT and image I LoG Perform fusion operation to get image I fuse ; for image I fuse Perform cell segmentation to obtain cell nucleus segmentation images. The present invention converts color images into grayscale images I gray Segmentation can avoid the nuclei misdetection and missed detection problems caused by uneven color distribution in the original image. The present invention uses a constrained local threshold method combined with a LoG algorithm to obtain cell nucleus pixel points, which can avoid the problem of false detection and missed detection of cell nuclei caused by uneven intensity distribution in the original image.

Description

technical field [0001] The present invention relates to the technical field of image processing, in particular to a cell segmentation method, device and computer-readable storage medium. Background technique [0002] Analysis of pathological images is an important clinical and research tool for tumor diagnosis and assessment. However, conventional manual-based qualitative or semi-quantitative analysis often has subjectivity, individual differences, and irreproducibility. The cell nucleus is the basic unit of pathological images, and it is usually the place where biomarkers are concentrated. The automatic segmentation and counting technology of cell nuclei based on image processing can obtain objective quantitative data quickly, accurately and reproducibly, thereby improving the analysis efficiency of pathological images. The difficulty of cell nucleus segmentation and counting lies in the diversity of cell nucleus morphology, uneven intensity or staining distribution of nu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T7/136G06T7/90
CPCG06T2207/20152G06T2207/20221G06T2207/30024G06T7/136G06T7/90
Inventor 束劼张永梅高齐阳
Owner NORTH CHINA UNIVERSITY OF TECHNOLOGY
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