Self-lubricating composite filler for intelligent dressing and preparation method thereof

A composite filler and self-lubricating technology, used in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problems of poor conductivity, short service life, and poor durability of dressings, prevent slippage, improve wear resistance, and increase strength. and durability effect

Inactive Publication Date: 2020-06-23
SICHUAN SHIMIAN JUFENG POWDER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem is that the patent documents are still based on the characteristics of traditional dressings, which cannot be combined with smart dressings, and cannot be used for targeted treatment of wounds through real-time monitoring.
[0005] 1. The dressing layer for assembling the intelligent sensing dressing requires higher strength and durability. Therefore, inorganic powder is needed as

Method used

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  • Self-lubricating composite filler for intelligent dressing and preparation method thereof
  • Self-lubricating composite filler for intelligent dressing and preparation method thereof
  • Self-lubricating composite filler for intelligent dressing and preparation method thereof

Examples

Experimental program
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Effect test

Example Embodiment

[0032] Example 1

[0033] The self-lubricating composite filler for smart dressing provided in this embodiment includes the following raw materials by mass percentage: 21% of hydroxyapatite; 5% of fluorinated graphene; 42% of calcium carbonate; 30% of conductive polymer; agent 2%. The hydroxyapatite is in the shape of nanorods, with a diameter of 10-15 nm and an aspect ratio of 10-13. The calcium carbonate is spherical calcium carbonate with a particle size of 40-50 μm. The molecular structural formula of the conductive polymer is:

[0034]

[0035] The adjuvant is a mixed adjuvant formed by transglutaminase (TG) and polyphenol oxidase (PPO).

[0036] A preparation method of a self-lubricating composite filler for intelligent dressing provided by the present invention includes the following steps: (1) Preparation of grade ingredients: respectively adding hydroxyapatite and calcium carbonate to a V-type mixer according to the mass ratio, and at 50 Under the condition of ...

Example Embodiment

[0037] Example 2

[0038] The self-lubricating composite filler for smart dressing provided in this embodiment includes the following raw materials by mass percentage: 21% of hydroxyapatite; 5% of fluorinated graphene; 42% of calcium carbonate; 30% of conductive polymer; agent 2%. The hydroxyapatite is in the shape of nano rods, with a diameter of 12-15 nm and an aspect ratio of 12-15. The calcium carbonate is spherical calcium carbonate with a particle size of 40-50 μm. The molecular structural formula of the conductive polymer is:

[0039]

[0040] The auxiliary agent is a mixed auxiliary agent formed by glutaraldehyde and polyphenol oxidase (PPO).

[0041] A preparation method of self-lubricating composite filler for intelligent dressing provided by the present invention includes the following steps: (1) preparation of grade ingredients: respectively adding hydroxyapatite and calcium carbonate to a V-type mixer according to mass ratio, and at 80 Under the condition o...

Example Embodiment

[0042] Example 3

[0043] The self-lubricating composite filler for smart dressing provided in this embodiment includes the following raw materials by mass percentage: 21% of hydroxyapatite; 5% of fluorinated graphene; 42% of calcium carbonate; 30% of conductive polymer; agent 2%. The hydroxyapatite is in the shape of nanorods, with a diameter of 10-15 nm and an aspect ratio of 12-14. The calcium carbonate is spherical calcium carbonate with a particle size of 40-45 μm. The molecular structural formula of the conductive polymer is:

[0044]

[0045] The auxiliary agent is a mixed auxiliary agent formed by transglutaminase (TG) and glutaraldehyde.

[0046] A preparation method of a self-lubricating composite filler for intelligent dressing provided by the present invention includes the following steps: (1) Preparation of grade ingredients: respectively adding hydroxyapatite and calcium carbonate to a V-type mixer according to the mass ratio, at 70 Under the condition of ...

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Abstract

The invention discloses a self-lubricating composite filler for intelligent dressing. The self-lubricating composite filler for intelligent dressing includes the following raw materials of: hydroxyapatite 20% to 25%, fluorinated graphene 3% to 5%, calcium carbonate 35% to 45%, conductive polymer 25% to 30%, and additives 1% to 2% in mass percentages. The preparation method of the self-lubricatingcomposite filler for intelligent dressing includes the following steps of: (1) preparation of grading ingredients; (2) mixing of additives; and (3) thermal cross-linking of the conductive polymer. Inthe invention, a grading structure is formed by micron order calcium carbonate and nano-hydroxyapatite, which greatly increases the strength and durability of the dressing; and the use of a sheet structure of fluorinated graphene and the low surface energy of fluorine atoms improve the wear resistance and achieve the purpose of self-lubrication. Meanwhile, the thermal cross-linking structure of the conductive polymer can fully cover the powder materials, so as to prevent the powder materials from slipping. The self-lubricating composite filler for intelligent dressing disclosed by the invention has the characteristics of high strength, high conductivity, and self-lubrication, can be used with various intelligent sensors, and is a composite filler of a multifunctional intelligent dressing.

Description

technical field [0001] The invention belongs to the technical field of dressings, and in particular relates to a self-lubricating composite filler for smart dressings and a preparation method thereof. Background technique [0002] Medical dressing is a kind of medical material used to cover wounds and treat wounds. It plays an important role in the treatment and repair of tissue wounds. Traditional medical dressings mainly include fiber, hydrogel, and polymer film dressings. In the actual use process, although it can play a certain role in hemostasis and accelerated wound repair, as people's awareness of medical care continues to increase, medical devices and medical products are also continuously improved and developed. A single dressing no longer satisfies the functional index requirements. For example, new dressings require high air permeability, no adhesion to tissues, and no scars. [0003] Chinese patent (application number 201220703964.9) discloses a medical hydrogel...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/18A61L15/24
CPCA61L15/18A61L15/24A61L15/42A61L2400/10A61L2400/12C08L33/24
Inventor 魏强高万超陈绍清罗义果郑建兰高剑罗晴
Owner SICHUAN SHIMIAN JUFENG POWDER
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