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A kind of suspending agent and suspension liquid of rabbit coccidiosis live attenuated vaccine

A technology for live attenuated vaccine and rabbit coccidiosis, which is applied in the directions of liquid transportation, allergic diseases, emulsion transportation, etc., can solve the problems of waste, high production cost, poor solubility of suspending agent, etc. Fast dissolving effect

Active Publication Date: 2022-05-20
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the coccidia vaccine suspensions currently used in chickens are relatively complicated in components, and the required production costs are relatively high
In addition, the existing suspending agents used in chickens also have the problem of poor solubility of the suspending agents. Since most colloids are relatively insoluble, a lot of time will be wasted for dissolving the suspending agents in production and application.

Method used

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  • A kind of suspending agent and suspension liquid of rabbit coccidiosis live attenuated vaccine
  • A kind of suspending agent and suspension liquid of rabbit coccidiosis live attenuated vaccine
  • A kind of suspending agent and suspension liquid of rabbit coccidiosis live attenuated vaccine

Examples

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Effect test

preparation example Construction

[0042] The preparation process of the rabbit coccidiosis live attenuated vaccine used is as follows: Eimeria large, Eimeria medium, and Eimeria intestinalis precocious line are separated and purified by coccidia oocysts, sporulated According to 150 oocysts / head of the precocious and attenuated strain of Eimeria large, 800 oocysts / head of the precocious and attenuated strain of Eimeria intestinalis, and 3000 eggs of the precocious and attenuated strain of Eimeria medium Capsule / head portion ratio is mixed.

[0043] Wherein, the Eimeria large, Eimeria medium, and Eimeria intestinalis precocious strains are consistent with the corresponding coccidia used in the specific embodiment of CN110694058A.

[0044] The experimental animals were 30-day-old rabbits, purchased from Zhuolu Guangyi Rabbit Industry Cooperative in Zhangjiakou City, Hebei Province, and raised in isolators without coccidia contamination.

[0045] If no specific technique or condition is indicated in the examples,...

Embodiment 1

[0047] The present embodiment provides a kind of suspending agent of live attenuated coccidiosis vaccine for rabbits, which contains a suspending compound with a mass fraction of 0.2‰ and KCl with a mass fraction of 1%. The mass ratio of the suspended compound is 1: 1 composition of pectin and xanthan gum.

[0048] The preparation method is as follows: taking pectin, xanthan gum and KCl respectively according to parts by mass, mixing with water and stirring until uniform.

Embodiment 2

[0050] This example provides a suspension of live attenuated coccidiosis vaccine for rabbits, the difference from Example 1 is that the mass fraction of KCl is 0.8%.

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Abstract

The invention relates to veterinary parasitology and immunobiology, in particular to a suspending agent and a suspension of a rabbit coccidiosis live attenuated vaccine. The suspension of live attenuated coccidiosis vaccine for rabbits contains a suspending compound with a mass fraction of 0.15-0.3‰, and the suspending compound consists of pectin and yellow Raw gum composition. The live attenuated coccidiosis vaccine suspending agent for rabbits in the present invention can realize the immunization of rabbits by drinking water. In addition, the suspending agent dissolves quickly at normal temperature, and can make rabbit coccidiosis oocysts form uniform dispersion in water The system, and keep it without sinking for more than 6 hours, ensures the uniformity of rabbit coccidiosis live vaccine immunity, and provides strong technical support for the promotion and application of rabbit coccidiosis live attenuated vaccine in actual production.

Description

technical field [0001] The invention relates to veterinary parasitology and immunobiology, in particular to a suspending agent and a suspension of a rabbit coccidiosis live attenuated vaccine. Background technique [0002] Rabbit coccidiosis is a parasitic disease caused by Eimeria coccidia parasitizing in the bile duct or intestinal tract. This disease is listed as the four major rabbit diseases together with rabbit plague, rabbit pasteurella, and rabbit scabies. Among them, rabbit coccidiosis is the most common and the most serious parasitic disease. There are many kinds of coccidia in the genus Eimeria rabbits, and currently 11 species are recognized internationally, while the main popular species in my country are Eimeria magna, Eimeria media, and Eimeria intestinalis. etc. All breeds of rabbits are susceptible to Eimeria, and rabbits of 1-4 months of age are the most susceptible. Young rabbits have a high mortality rate after infection, and become long-term carriers af...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/012A61K9/10A61K39/39A61K47/36A61P33/02A61P37/04
CPCA61K39/012A61K9/10A61K39/39A61K47/36A61P37/04A61P33/02A61K2039/522A61K2039/542Y02A50/30
Inventor 刘贤勇索勋邓梦青胡丹丹成霞罗光琴索静霞汤新明
Owner CHINA AGRI UNIV
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