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Detection method of 2-ethylbutyl ((perfluorophenoxy)(phenoxy)phosphoryl)-L-alanine ester

A perfluorophenoxy and ethylbutyl technology, which is applied in the field of chemical substance detection, can solve the problems of hindering the research of new coronavirus pneumonia of Remdesivir, difficult to control the quality of intermediates, and difficult to know the purity of intermediates. , to achieve the effect of promoting the research and development process and accurate test results

Active Publication Date: 2020-07-10
广州隽沐生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps detect harmful substances like virus particles or other contaminants from biological samples such as blood plasma for better monitoring their health statuses. It also provides precise measurement data with high accuracy compared to previous methods used before testing them against viruses. Overall, this technology improves safety measures for patients who require treatments due to novel Coronoviral Disease (COVID).

Problems solved by technology

Technological Problem addressed in this patented technical problem relating to improving the production process of Remodesiprasidium bicronate used alone or together with other drugs like etamibratorin triiodoarsimod hydrochlorothiazolon salt in treating COVID-19 patients are related issues such as lack of clarification on how much impurities can be found during manufacturing processes leading to instability over time due to changes made throughout storage conditions.

Method used

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  • Detection method of 2-ethylbutyl ((perfluorophenoxy)(phenoxy)phosphoryl)-L-alanine ester
  • Detection method of 2-ethylbutyl ((perfluorophenoxy)(phenoxy)phosphoryl)-L-alanine ester
  • Detection method of 2-ethylbutyl ((perfluorophenoxy)(phenoxy)phosphoryl)-L-alanine ester

Examples

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Embodiment 1

[0046] refer to figure 1 , is the detection method of a kind of 2-ethylbutyl ((perfluorophenoxy) (phenoxy) phosphoryl)-L-alanine ester disclosed by the present invention, comprising the following steps:

[0047] Step 1) Weigh 0.5 mg of 2-ethylbutyl ((perfluorophenoxy) (phenoxy) phosphoryl)-L-alanine ester sample, add 1 mL of methanol to a 5 mL volumetric flask, and 2 -Ethylbutyl ((perfluorophenoxy) (phenoxy) phosphoryl)-L-alanine ester sample is dropped into methanol, shake the volumetric flask until transparent, so that 2-ethylbutyl (( Perfluorophenoxy) (phenoxy) phosphoryl)-L-alanine ester sample is dissolved in methanol to form a pretreatment solution;

[0048] Step 2) Add methanol to the pretreatment solution to make the volume to 5 mL, shake the volumetric flask for 1 min, and mix well to dilute the pretreatment solution to form a sample solution;

[0049] Step 3) Take 20ul sample solution and inject it into the liquid chromatograph for detection, and record the chromat...

Embodiment 2

[0054] Compared with Example 1, the difference is only in:

[0055] In the mobile phase, the mass ratio of potassium dihydrogen phosphate solution, methanol, and acetonitrile is 10:30:60.

Embodiment 3

[0057] Compared with Example 1, the difference is only in:

[0058] In the mobile phase, the mass ratio of potassium dihydrogen phosphate solution, methanol, and acetonitrile is 20:30:50.

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Abstract

The invention relates to the field of chemical substance detection, in particular to a detection method of 2-ethylbutyl((perfluorophenoxy)(phenoxy)phosphoryl)-L-alanine ester. The method comprises thefollowing steps: 1) dissolving a 2-ethylbutyl((perfluorophenoxy)(phenoxy)phosphoryl)-L-alanine ester sample with methanol to form a pretreatment solution; 2) adding methanol into the pretreatment solution for dilution to form a sample solution, and 3) injecting the sample solution into a liquid chromatograph for detection and recording a chromatogram. The method has the effect of facilitating rapid promotion of the research and development process of novel coronavirus pneumonia drugs.

Description

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Claims

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Application Information

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Owner 广州隽沐生物科技股份有限公司
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