Preparation process of solifenacin succinate tablet composition

Abstract

The invention discloses a preparation process of a solifenacin succinate tablet composition. The preparation process comprises the following specific preparation steps: step 1, pretreatment: sieving solifenacin succinate and lactose by a 40-mesh sieve for later use; step 2, weighing: according to a batch prescription, re-checking and weighing the solifenacin succinate, the lactose, corn starch andhydroxypropyl methylcellulose by two persons; step 3, solution preparation: preparing 460g of 8% hydroxypropyl methylcellulose solution from the weighed hydroxypropyl methylcellulose; and step 4, preheating and primary mixing: according to the batch prescription, after the feeding amount is checked by two persons, sequentially adding the lactose, the solifenacin succinate (more different in process, directly adding or adding together with an adhesive) and the corn starch into a multifunctional fluidized bed in sequence, and preheating and mixing for 12min. The preparation effect is more outstanding by utilizing the cooperation of multiple steps, and the process is simple compared with the existing preparation technology, large-batch production can be carried out, and the production cost is greatly reduced.

Description

technical field [0001] The invention relates to a preparation process of a solifenacin succinate tablet composition, and belongs to the technical field of solifenacin succinate tablets. Background technique [0002] Solifenacin is a competitive muscarinic receptor antagonist, more selective for the bladder than the salivary gland, and the muscarinic M3 receptor plays an important role in several functions mediated primarily by cholinergics, including contraction of the bladder Smooth muscle and stimulate saliva secretion, solifenacin succinate inhibits the overactivity of the detrusor muscle by blocking the muscarinic M3 receptors of the bladder smooth muscle, thereby alleviating the urge incontinence, urgency and frequency associated with overactive bladder symptom. [0003] At present, the preparation process of the existing solifenacin succinate tablet composition is relatively complicated, and it is difficult to produce in large quantities, resulting in relatively high ...

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of preparation technology of solifenacin succinate tablet composition and using method thereof, to solve the preparation technology production process of existing solifenacin succinate tablet composition proposed in the above-mentioned background technology is relatively complicated, It is difficult to produce in large quantities, resulting in high production costs