Biomarker related to specific immunotherapy of dust mite related asthma of children and application

A biomarker and immunotherapy technology, applied in biomarkers and application fields, can solve problems such as body injury, achieve great application significance and economic value, and avoid economic loss and body injury

Active Publication Date: 2020-07-24
FOSHAN MATERNAL & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there is still a lack of biomarkers and detection methods that can be routinely used for the screening of patients with immunotherapy and the prediction of curative effect. Economic lo

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  • Biomarker related to specific immunotherapy of dust mite related asthma of children and application
  • Biomarker related to specific immunotherapy of dust mite related asthma of children and application
  • Biomarker related to specific immunotherapy of dust mite related asthma of children and application

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Embodiment Construction

[0018] The present invention provides biomarkers and applications related to the specific immunotherapy of dust mite-associated asthma in children. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail with reference to the accompanying drawings and examples . It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention. For the specific experimental methods not indicated in the following examples, conventional methods are generally used, and various commonly used chemical reagents used in the examples are all commercially available products.

[0019] A method for screening children dust mite-associated asthma-specific immunotherapy biomarkers, said method comprising the steps of:

[0020] S1. Collect subjects' samples;

[0021] S2. Determine and / or quantify keratin 1 in the su...

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Abstract

The invention discloses a biomarker related to specific immunotherapy of dust mite related asthma of children and application. The biomarker is keratin 1, and the invention also discloses applicationof the biomarker to preparation of a reagent, a kit, test paper or a chip for auxiliary screening of patients of specific immunotherapy of the dust mite related asthma of the children. According to the biomarker and the application of the biomarker, the blank that a biomarker which can be conventionally used for immunotherapy patient screening and curative effect pre-judgment is still lacked at present is filled up; and the biomarker is closely related to the specific immunotherapy of the dust mite related asthma of the children, is beneficial to accurate selection of the children patients suitable for the specific immunotherapy, avoids economic losses and body injuries caused by immunotherapy of the children patients with poor curative effects, and has great application significance and economic value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a biomarker and its application related to the specific immunotherapy of dust mite-associated asthma in children. Background technique [0002] Bronchial asthma is the most common chronic disease in childhood. Its disease course is long and easy to recur, seriously affecting children's physical and mental health, and causing huge mental and economic burdens to children's families and society. Asthma is a complex airway disease, which is chronic airway inflammation and airway remodeling caused by environmental factors, immune factors, and genetic factors. Allergens are independent risk factors for asthma, and dust mite-associated bronchial asthma is the most common type of asthma. Allergen-specific immunotherapy is the only cause-based therapy that can change the natural course of allergic diseases. Allergen-specific immunotherapy mainly includes SCIT (subcutaneous immunotherapy...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2333/4742G01N2800/122
Inventor 白珺廖旺钟嘉泳陈亮
Owner FOSHAN MATERNAL & CHILD HEALTH CARE HOSPITAL
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