Water-soluble coenzyme Q10 composition and preparation method thereof

A water-soluble, composition-based technology, applied in the chemical field, can solve problems such as poor stability, low encapsulation rate, and incomplete inclusion, and achieve the effects of wide application range, simple process flow, and easy operation

Pending Publication Date: 2020-07-31
上海融澈水性材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, cyclodextrin is used as the encapsulation material. Although the cladding effect is very good, it can only enclose the quinone ring of coenzyme Q10, and the long chain of coenzyme Q10 is exposed, which cannot be completely encapsulated and placed for a period of time. After the coenzyme Q10 will be precipitated, the stability is not good, and the encapsulation efficiency is not high

Method used

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  • Water-soluble coenzyme Q10 composition and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0050]Embodiment 1, preparation of water-soluble coenzyme Q10 composition

[0051] The preparation method of water-soluble coenzyme Q10 composition comprises the steps:

[0052] (1) Weigh 10g of β-cyclodextrin, dissolve it in 300g of water to obtain an aqueous solution of cyclodextrin, heat it to 60°C, and put it into a high-speed shear; dissolve 10g of coenzyme Q10 in 20g of absolute ethanol, and then add it to In the above cyclodextrin solution, perform high-speed homogenization at a speed of 5000 rpm for 40 minutes, discharge, add to a grinder, grind for 5 minutes, and discharge to obtain an inclusion compound;

[0053] (2), the primary clathrate of step (1) is added in a high-pressure homogenizer, 10g of PVPK30 is dissolved into an aqueous solution with 50g of water, then added to a high-pressure homogenizer, circulated 10 times at 80Mpa, discharged, and then sprayed Dried to obtain a water-soluble coenzyme Q10 composition.

[0054] The encapsulation efficiency of the de...

Embodiment 2

[0056] Embodiment 2, preparation of water-soluble coenzyme Q10 composition

[0057] The preparation method of water-soluble coenzyme Q10 composition comprises the steps:

[0058] (1) Weigh 50g of β-cyclodextrin, dissolve it in 1500g of water to obtain an aqueous solution of cyclodextrin, heat it to 60°C, and put it into a high-speed shear; dissolve 1g of coenzyme Q10 in 3g of absolute ethanol, and then add it to In the cyclodextrin aqueous solution, homogenize at a high speed of 10,000 rpm for 20 minutes, discharge, add to a grinder, grind for 3 minutes, and discharge to obtain an inclusion compound;

[0059] (2), the primary clathrate of step (1) is added to the high-pressure homogenizer, 50g of PVPK30 is dissolved into an aqueous solution with 250g of water, then added to the high-pressure homogenizer, circulated once at 80Mpa, discharged, and then sprayed Dried to obtain a water-soluble coenzyme Q10 composition.

[0060] The encapsulation efficiency of the detection water...

Embodiment 3

[0062] Example 3, preparation of water-soluble coenzyme Q10 composition

[0063] The preparation method of water-soluble coenzyme Q10 composition comprises the steps:

[0064] (1) Weigh 20g of β-cyclodextrin, dissolve it in 1000g of water to obtain an aqueous solution of cyclodextrin, heat it to 60°C, and put it into a high-speed shear; dissolve 1g of coenzyme Q10 in 5g of absolute ethanol, and then add it to In the cyclodextrin aqueous solution, homogenize at a high speed of 7500rpm for 30 minutes, discharge, add to a grinder, grind for 4 minutes, discharge to obtain an inclusion compound;

[0065] (2), the primary inclusion compound of step (1) is added to a high-pressure homogenizer, 30g of PVPK30 is dissolved into an aqueous solution with 200g of water, then added to a high-pressure homogenizer, circulated once at 120Mpa, discharged, and then sprayed Dried to obtain a water-soluble coenzyme Q10 composition.

[0066] The encapsulation efficiency of the detection water-sol...

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Abstract

The invention provides a preparation method of a water-soluble coenzyme Q10 composition. The preparation method comprises the following preparation steps: (1) dissolving a formula amount of cyclodextrin into a proper amount of water to obtain a cyclodextrin aqueous solution, heating the cyclodextrin aqueous solution, dissolving a formula amount of coenzyme Q10 into a proper amount of absolute ethyl alcohol, then adding the obtained coenzyme Q10 solution into the cyclodextrin aqueous solution, carrying out high-speed homogenization treatment, discharging the mixture into a grinding machine forgrinding, and performing discharging to obtain a primary inclusion compound; and (2) dissolving a secondary embedding wall material in a proper amount of water to form a secondary embedding wall material aqueous solution, adding the secondary embedding wall material aqueous solution into the primary inclusion compound obtained in the step (1), putting the mixture into a high-pressure homogenizer,performing circulating for 1-10 times at 80-180Mpa, and performing discharging and drying. The secondary embedding wall material is selected from one or more of hydroxyethyl cellulose, poloxamer 188,PVP (Polyvinyl Pyrrolidone), PEG4000 (Polyethylene Glycol 4000), PEG6000 (Polyethylene Glycol 6000), gelatin and Arabic gum. According to the preparation method, the encapsulation efficiency of the coenzyme Q10 can be improved, and stability of the coenzyme Q10 composition in an aqueous solution can be effectively improved.

Description

technical field [0001] The invention belongs to the field of chemistry and relates to a water-soluble coenzyme Q10 composition and a preparation method thereof. Background technique [0002] Coenzyme Q10 (CoQ10), also known as ubiquinone, is a lipophilic chemical substance endogenously synthesized in human and various animal and plant cells. It consists of a benzoquinone ring connected to a side chain containing 10 isoprenoid units. CoQ10 is an indispensable and important physiological substance in the human body. Its chemical structure determines that it has many important physiological functions in the human body. It is an important transfer substance in life activities and a key substance in the rate-limiting reaction of the mitochondrial respiratory chain. , plays an important role in cellular energy generation and enhances biological vitality. CoQ10 is a rare compound that integrates medical use, nutrition and health care. Its value and potential in the fields of medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K9/50A61K31/122A61P39/00A23L33/10A61K8/11A61K8/35A61K8/73A61Q19/00
CPCA61K47/6951A61K31/122A61K9/5026A61K9/5042A61K9/5031A61K9/5057A61K9/5036A61P39/00A61K8/355A61K8/738A61K8/11A61Q19/00A23L33/10A61K2800/10
Inventor 王宇周敬扩朱广东陈占魏亚娜
Owner 上海融澈水性材料有限公司
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