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157results about How to "Optimize spatial structure" patented technology

Electrochemical sensor based on metal organic framework-vertical graphene composite structure and preparation method thereof

InactiveCN108982622AOptimized inductive and conductive performanceOptimize device functionalityMaterial electrochemical variablesAmount of substanceMetal-organic framework
The invention belongs to the technical field of biosensors, and in particular discloses an electrochemical sensor based on a metal organic framework-vertical graphene composite structure and a preparation method thereof. The preparation method specifically comprises the following steps: (1) growing vertical graphene on a stainless steel substrate; (2) synthesizing various different metal organic framework (MOF for short) materials such as ZIF-8, KAUST-1 and Ni-MIL-77 by taking the vertical graphene on the stainless steel substrate as a template; and (4) constructing the electrochemical sensorby taking the MOF-vertical graphene composite nanostructure as an electrode material. The electrochemical sensor has higher electric conductivity, larger specific surface area and more types of responsive substance surfaces, and the preparation method is relatively clear, different MOFs can be made by selecting materials according to performance of chemical reactions directly, and the spatial structure of the MOF material can be altered according to performance demand, so that the electrochemical sensor which further meets the demand can be manufactured more easily, and is wide in applicationrange.
Owner:SUN YAT SEN UNIV

Method for preparing bacterial cellulose compounded amnion extracellular matrix material containing collagen

The invention discloses a method for preparing a bacterial cellulose compounded amnion extracellular matrix material containing collagen, and relates to a preparation technology of tissue engineering biomaterials. The method comprises the following steps: activating a strain capable of secreting bacterial cellulose to prepare a seed mash; mixing the seed mash with strain concentration of 30-50wt% and a culture medium containing a collagen solution, and putting the mixture into a culture container to stand and culture to obtain a bacterial cellulose / collagen film; immersing an amnion extracellular matrix film in the culture medium, laying the amnion extracellular matrix film on the surface of the bacterial cellulose / collagen film after the amnion extracellular matrix film is completely wet; further standing and culturing for 1-6 hours, purifying and drying to obtain the bacterial cellulose compounded amnion extracellular matrix material containing collagen. The method is simple and practical in preparation process, low in cost and wide in material sources; the prepared compound material has an excellent spatial three-dimensional network, good biocompatibility and high mechanical strength, and can be used as a tissue engineering scaffold material and applied to tissue reconstruction.
Owner:钟春燕

Type 1 bovine viral diarrhea virus-like particle as well as preparation and application thereof

The invention discloses a type 1 bovine viral diarrhea virus (BVDV-1) virus-like particle as well as a preparation method and application thereof. A pFBD-BVDV-1 recombinant baculovirus transfer vectoris built by cloning structural protein C, Erns, E1 and E2 coding genes of BVDV-1 to pFastBacDual; a recombinant baculovirus vector Bac-BVDV-1 is obtained through the transposition in colibacillus DH10Bac; insect cells are transfected; recombinant baculovirus Baculo-BVDV-1 is obtained; the structural protein C, Erns, E1 and E2 of the insect cells for expressing BVDV-1 are infected and are automatically assembled into BVDV-1 virus-like particles (VLP) in the cells. The obtained virus-like particle is more similar to the morphostructure of the natural BVDV virus particles; after the inoculationinto animals, the bodies can be stimulated to generate good immune reaction; a better immune effect can be reached. The obtained virus-like particle can be directly purified by using the sucrose density gradient centrifugation. Compared with other expression systems, the virus-like particle has the advantages that the complicated process of extracellular assembly after the respectively purification of the structural protein is avoided; the efficiency is favorably improved; the cost is reduced; in addition, in the production process, the infective BVDV living viruses are not needed; the safetyis improved.
Owner:LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI

Parkinson hand motion quantitative analysis method and system based on depth image

ActiveCN110991268AProtect Patient PrivacyImprove the accuracy of quantitative analysisImage enhancementImage analysisFeature (machine learning)Image based
The invention discloses a Parkinson's hand motion quantitative analysis method and system based on a depth image, and belongs to the field of computer vision and machine learning. The method comprisesthe steps that a detected person makes a hand action according to the requirements of a Parkinson's disease evaluation table, multiple frames of depth images of the detected person are acquired in the period, and 3D coordinates of the hand centroid in each frame of depth image are recognized; according to the 3D coordinates of the hand centroid, hand point cloud and noise point cloud segmentationis carried out on each frame of depth image; predicting 3D coordinates of each hand joint point in each frame of depth image based on the hand point cloud in the single frame of depth image; integrally optimizing the 3D coordinates of all the hand joint points of all the frames according to the time sequence information between the continuous frames and the priori knowledge of the hand postures;according to the optimized articulation point 3D coordinates, hand motion features are extracted; and utilizing the trained XGBoost classifier to classify the extracted hand motion features, and giving a corresponding scoring result.
Owner:HUAZHONG UNIV OF SCI & TECH

Biological fermentation preparation method for flavored pigskin

The invention relates to a biological fermentation preparation method for flavored pigskin. The biological fermentation preparation method comprises the following steps: sterilizing a byproduct, namely pigskin of the pork industry, then performing micro-point roughening treatment of mixed protease on the surface of the pigskin, adding a carbon source and a nitrogen source required by fermentation,inoculating mucor racemosus XH-22, bacillus subtilis and aspergillus oryzae, and performing mixed solid-state fermentation, after surface hyphae are removed, inoculating yeast, the mucor racemosus XH-22 and the aspergillus oryzae, carrying out compensation fermentation on the pigskin, and subjecting a fermentation product to flavoring, drying and dehydration so as to obtain a product, namely fermented flavored pigskin. The flavored fermented pigskin produced by using the method provided by the invention has the following advantages: the production process is environmentally-friendly, simple,convenient, economical and practical; the difficulties of a conventional method in industrial production is overcome; meanwhile, the deficiencies of a conventional product in the aspects of nutritionand flavor can be made up; excellent flavor is guaranteed; and high-quality collagen is taken as a source of healthy energy at the same time.
Owner:ZHEJIANG UNIV OF TECH

Microporous composite biological ceramic bone repair scaffold as well as preparation method and device thereof

The invention discloses a microporous composite biological ceramic bone repair scaffold and a preparation method and device thereof. The repair scaffold comprises a repair scaffold body made of a composite material, the repair scaffold body comprises a plurality of scaffold layers which are overlapped, a plurality of micron-sized micropores are formed in each scaffold layer, and a plurality of micropores among the layers form a plurality of polyhedrons. The composite material comprises the following components in percentage by weight: 1%-5% of graphene, 50%-60% of zirconium oxide and 20%-40% of hydroxyapatite and beta-tricalcium phosphate. The polyhedrons are connected by the micropores, the conductivity and the high toughness of the graphene are utilized, the high strength and the wear resistance of the zirconium oxide are utilized, and the good bone induction activity of the hydroxyapatite and beta-tricalcium phosphate is utilized, so that the physical properties such as compressivestrength, elastic modulus, fracture toughness and other indexes of the new material are close to natural bone tissue, the new material can bear the large stress deformation without fracture, the wearcondition between the material and the adjacent tissue is reduced, and the new material has high osteogenesis induction activity at the same time.
Owner:BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV

Long-focal-length large-view-field miniaturized active athermalization optical system

PendingCN113805325AHigh resolutionWide temperature range operationOptical elementsImaging lensOptic system
The invention discloses a long-focal-length large-view-field miniaturized active athermalization optical system which comprises a Cassegrain reflection primary mirror, a reflection secondary mirror, a field lens, a collimating mirror, a first folding mirror, a second folding mirror, a first imaging mirror group, a third folding mirror, a second imaging mirror group, a fourth folding mirror, an imaging lens and a detector focal plane. The Cassegrain reflection primary mirror and the reflection secondary mirror form a Cassegrain imaging system, the field lens is arranged between the Cassegrain reflection primary mirror and the reflection secondary mirror, and the field lens is used for compressing the field angle of the collimating mirror and correcting the field curvature of the imaging system; and the collimating lens, the first folding lens, the second folding lens, the first imaging lens group, the third folding lens, the second imaging lens group, the fourth folding lens, the imaging lens and the detector focal plane are sequentially connected through light paths. The system can work in a wide temperature range, the cost of the system is reduced, meanwhile, the space structure of the system is optimized through the turning mirror, and miniaturization is achieved.
Owner:AEROSPACE SCI & IND MICROELECTRONICS SYST INST CO LTD

Method for preparing bacterial cellulose compounded amnion extracellular matrix material containing collagen

The invention discloses a method for preparing a bacterial cellulose compounded amnion extracellular matrix material containing collagen, and relates to a preparation technology of tissue engineering biomaterials. The method comprises the following steps: activating a strain capable of secreting bacterial cellulose to prepare a seed mash; mixing the seed mash with strain concentration of 30-50wt% and a culture medium containing a collagen solution, and putting the mixture into a culture container to stand and culture to obtain a bacterial cellulose / collagen film; immersing an amnion extracellular matrix film in the culture medium, laying the amnion extracellular matrix film on the surface of the bacterial cellulose / collagen film after the amnion extracellular matrix film is completely wet; further standing and culturing for 1-6 hours, purifying and drying to obtain the bacterial cellulose compounded amnion extracellular matrix material containing collagen. The method is simple and practical in preparation process, low in cost and wide in material sources; the prepared compound material has an excellent spatial three-dimensional network, good biocompatibility and high mechanical strength, and can be used as a tissue engineering scaffold material and applied to tissue reconstruction.
Owner:钟春燕
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