Benzo [c] benzopyrone derivative and application thereof

A technology of benzopyrone and benzopyran, which is applied in the field of benzo[c]benzopyrone derivatives and their application in the treatment of cancer diseases, and achieves the effect of obvious proliferation inhibition
CN111499608AActive Publication Date: 2020-08-07WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV
Publication Date
2020-08-07

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Abstract

The invention discloses a benzo [c] benzopyrone derivative and application thereof. A series of chemical derivatives containing a Uro B skeleton (benzo [c] benzopyrone) as shown in a formula (I) are designed and synthesized by introducing different N-terminal end groups into a urolith derivative through a 1, 3-dibromopropane bridge chain. The invention can be applied to preparation of various anti-tumor drugs and is especially suitable for bladder cancer.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry, and specifically relates to a benzo[c]benzopyrone derivative and its application in treating cancer diseases. Background technique

[0002] Bladder cancer is the most common malignant tumor of the urinary system. The biological behavior of bladder tumors is complex and changeable, and they are prone to recurrence, invasion and metastasis. In addition to surgery, systemic chemotherapy has become the standard treatment for metastatic bladder cancer. Chemotherapeutic drugs commonly used in the treatment of bladder cancer include doxorubicin, hydroxycamptothecin, mitomycin, etc. However, due to the widespread emergence of drug resistance, bladder cancer cells are becoming less and less sensitive to these drugs. App doesn't work well. Therefore, the development of new anti-bladder cancer drugs is becoming more and more urgent. It is one of the hot spots in medical research to find low-toxicity an...

Claims

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