A kind of preparation technology of α-amyl alcohol fine particles

Abstract

The present invention relates to the technical field of balsam alcohol preparation technology, in particular to a preparation process of α-amyresin alcohol fine particles. The preparation process of the α-amyresin alcohol fine particles includes yeast synthesis, component extraction, critical expansion and inspection and packaging , wherein the reactor adopted in the critical expansion includes a mixing chamber, a negative pressure chamber and a controller; the center of the bottom of the negative pressure chamber is provided with a pretreatment pipe, and the top of the pretreatment pipe is provided with a nozzle; The degree of precipitation of micronuclei in the process of decompression and expansion is different, so that the particle size of the prepared fine particles is not stable enough, and the absorption effect of the fine particles in use is reduced; therefore, the present invention is installed on the bracket by rotating the mixing chamber , with the filter membrane in the negative pressure chamber, the particle size of the micronucleus crystals precipitated after the supercritical solution is decompressed and expanded is in a stable range, ensuring the absorption effect of the fine particles in use, thereby improving the α-amyresin alcohol The quality of preparation of fine particles.

Description

technical field [0001] The invention relates to the technical field of balsam alcohol preparation technology, in particular to a preparation process of α-amyl alcohol fine particles. Background technique [0002] Balsamol is a kind of triterpenoid compound, which widely exists in the plant kingdom in free or ester form. There are two isomers of balsamol in nature: α- balsamol and β- balsamol. The ursolic acid extracted from loquat leaves containing triterpene saponins has a wide range of pharmacological activities and has great application value. Body α-arysinol is very important. The content of ursolic acid and α-arysinol in plants is low, which is not conducive to extraction and cannot meet its medicinal needs. In recent years, using synthetic biology methods, through transformation The synthetic pathway of microorganisms realizes the mass production of medicinal ingredients, and shows the effect in the application of many medicinal ingredients; for the introduction of th...

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Problems solved by technology

[0004] There have also been some technical solutions for preparing α-amyresin fine particles in the prior art, such as a Chinese patent with the application number 2009102291585 disclosing a preparation process of α-amyresin fine particles. Critical fluid anti-solvent equipment, which consists of the following steps: configuration of α-amyresin liquid, carbon dioxide feed, α-amyresin crystallization, and inspection; Micronized particles are beneficial to human body absorption, can improve the solubility and curative effect of α-amyresinol, reduce the cost of use and side effects; the α-amyresinol ultrafine particles prepared in this technical scheme have unique advantages in clinical practice; but the The α-amyresin alcohol in the technical proposal is prepared by decompression and expansion in a supercritical fluid, and the equilibrium concentration of the solute in the supercritical fluid cannot be effectively controlled, so that the prepared α-amyresinol fine particles are used Absorption is affected in

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