Macrobrachium rosenbergii thymosin β4 gene, protein, preparation method and application thereof

A technology of Macrobrachium rosenbergii and thymosin, which is applied in the preparation methods of peptides, thymosin, peptide/protein components, etc., to achieve the effect of obvious antibacterial activity
CN111499720BActive Publication Date: 2022-06-14YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2022-06-14

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Abstract

The invention belongs to the field of genetic engineering of molecular biology, and relates to the nucleotide sequence and encoded amino acid sequence of macrobrachium rosenbergii thymosin β4 gene, as well as the codon-optimized nucleotide sequence, in particular to macrobrachium rosenbergii thymosin Preparation method for recombinant expression of β4 protein. The recombinant expression of MrThyβ4 protein can overcome the problem of low yield in the purification and separation process, further study the function of the protein, and lay the foundation for the wide application of the protein in the research fields of biology, medicine and agriculture.
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Description

technical field

[0001] The invention belongs to the field of genetic engineering of molecular biology, and relates to the nucleotide sequence and the coded amino acid sequence of the thymosin β4 gene of Macrobrachium rosenbergii (Macrobrachium rosenbergii) and the nucleotide sequence after codon optimization, in particular to Macrobrachium rosenbergii (Macrobrachium rosenbergii) rosenbergii) Preparation method for recombinant expression of thymosin β4 protein. Background technique

[0002] Thymosin widely exists in vertebrates and invertebrates, and can be divided into three types according to the different isoelectric points: Tα, Tβ, and Tγ. The functional domain of thymosin is a thymosin (THY) domain, and the β-thymosin protein in invertebrates usually has multiple domains. At present, thymosin participates in various biological functions of the body, including regulating actin and remodeling the cytoskeleton. In addition, β-thymosin protein can also play an important ro...

Claims

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