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A kind of amoxicillin continuous crystallization process

An amoxicillin and process technology, applied in the field of continuous crystallization process, can solve the problems of low production efficiency of amoxicillin crystallization process, and achieve the effects of high use efficiency of process equipment, low impurity residue and high crystallization rate

Active Publication Date: 2021-12-21
UNITED LAB INNER MONGOLIA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is to provide a kind of amoxicillin continuous crystallization technology, to solve the problem that the production efficiency of amoxicillin crystallization process is lower in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The continuous crystallization process of amoxicillin described in the present embodiment comprises the following steps:

[0034](1) Mix 1L of amoxicillin condensate with 1:1 hydrochloric acid at 2.0m 3 The flow rate of / h was mixed and acidified by a pipeline mixer to obtain an acidified solution with a pH value of 1.0. After testing, the content of acidified amoxicillin was 60 mg / mL;

[0035] (2) After filtering and clarifying the obtained acidification liquid, enter the first crystallization tank, slowly add 6M ammonia water, control the pH of the feed liquid to 1.6, control the stirring speed in the first crystallization tank to 25r / min, and the volume of the feed liquid after about 1.2h Reaching 80% of the volume of the crystallization tank, the discharge flows into the second-stage crystallization tank;

[0036] (3) In the second crystallization tank, continue to add 6M ammonia water to control the feed liquid pH=2.5, control the stirring speed to 25r / min, and af...

Embodiment 2

[0040] The continuous crystallization process of amoxicillin described in the present embodiment comprises the following steps:

[0041] (1) Mix 1L of amoxicillin condensate with 1:1 hydrochloric acid in 4.5m 3 The flow rate of / h was mixed and acidified by a pipeline mixer to obtain an acidified solution with a pH value of 1.5. After testing, the content of acidified amoxicillin was 60 mg / mL;

[0042] (2) After filtering and clarifying the obtained acidification liquid, enter the first crystallization tank, slowly add 6M ammonia water, control the pH of the feed solution to 2.0, control the stirring speed in the first crystallization tank to 25r / min, and the volume of the feed liquid after about 2.0h Reaching 80% of the volume of the crystallization tank, the discharge flows into the second-stage crystallization tank;

[0043] (3) In the second crystallization tank, continue to add 6M ammonia water to control the feed liquid pH=4.0, and control the stirring speed to 25r / min....

Embodiment 3

[0047] The continuous crystallization process of amoxicillin described in the present embodiment comprises the following steps:

[0048] (1) Mix 1L of amoxicillin condensate with 1:1 hydrochloric acid in 3.8m 3 The flow rate of / h was mixed and acidified by a pipeline mixer to obtain an acidified solution with a pH value of 1.3. After testing, the content of acidified amoxicillin was 60mg / mL;

[0049] (2) Enter the first crystallization tank after the obtained acidification solution is filtered and clarified, slowly add 6M ammonia water, control the pH of the feed liquid=1.8, control the stirring speed in the first crystallization tank to 25r / min, and the volume of the feed liquid after about 1.5h Reaching 80% of the volume of the crystallization tank, the discharge flows into the second-stage crystallization tank;

[0050] (3) In the second crystallization tank, continue to add 6M ammonia water to control the feed liquid pH=3.3, control the stirring speed to 25r / min, and aft...

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Abstract

The invention belongs to the technical field of drug crystallization, and in particular relates to a continuous crystallization process for effectively improving the production efficiency of amoxicillin. The amoxicillin continuous crystallization process of the present invention, firstly, the amoxicillin condensation liquid is acidified to pH<1.5, and then the crystal form of the crystal is controlled by controlling different pHs in three crystallization tanks, and the quality of the medicine is changed. The crystallization rate of amoxicillin is effectively improved, and the output and quality of amoxicillin are effectively improved; and during the entire crystallization process, the entire feeding, crystallizing, and discharging processes are completely uninterrupted, and the use efficiency of the overall process equipment is high, truly realizing Continuous crystallization of amoxicillin.

Description

technical field [0001] The invention belongs to the technical field of drug crystallization, and in particular relates to a continuous crystallization process for effectively improving the production efficiency of amoxicillin. Background technique [0002] Amoxicillin is a broad-spectrum penicillin antibiotic, which has been widely used at present. Due to the increasing domestic production capacity year by year, the market competitiveness has become increasingly fierce. In order to improve product competitiveness and occupy the market, product production efficiency and quality are particularly important. At present, the process of enzymatic production of amoxicillin has been basically popularized in China, but there is still a certain gap in its product quality stability and production cost, and the production efficiency and product quality of the amoxicillin pharmaceutical process need to be further improved. [0003] Crystallization is one of the most effective methods to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D499/68
CPCC07D499/68C07B2200/13
Inventor 宋国忠齐洲花远志刘天鹏李慕安
Owner UNITED LAB INNER MONGOLIA CO LTD
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