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Application of CCR1 as COPD diagnostic marker

A diagnostic marker, 1. CCR1 technology, applied in disease diagnosis, biological testing, biomaterial analysis, etc., can solve problems affecting test results and other issues

Pending Publication Date: 2020-08-14
SHANGHAI PUTUO DISTRICT PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the neutrophil function detected by this method can reflect the two functions of neutrophil phagocytosis and oxidation, and any functional defect will affect the detection results
[0007] There is no report about the application of CCR1 expression in the present invention as a COPD diagnostic marker

Method used

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  • Application of CCR1 as COPD diagnostic marker
  • Application of CCR1 as COPD diagnostic marker
  • Application of CCR1 as COPD diagnostic marker

Examples

Experimental program
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Embodiment 1

[0041] The COPD patient group consisted of 30 cases, including 16 males and 14 females, aged 35 to 82 years, all of whom were clinically diagnosed and admitted to the People's Hospital of Putuo District, Shanghai in the acute attack period of COPD from January 2018 to December 2019 patient. The clinical diagnosis includes physical signs, X-ray and laboratory related item tests, and the diagnosis complies with the diagnostic criteria in the Global Initiative for chronic obstructive pulmonary disease (GOLD) guidelines 2017. A total of 30 pneumonia patients (pneumonia group) who were diagnosed and hospitalized in Shanghai Putuo District People's Hospital during the same period were selected as disease controls, including 12 males and 18 females, aged 32-88 years. A total of 30 healthy persons (normal control group) who underwent physical examination at the People's Hospital of Putuo District, Shanghai during the same period were selected, including 14 males and 16 females, aged 2...

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Abstract

The invention relates to an application of CCR1 as a COPD diagnostic marker. A method comprises the following steps: detecting the peripheral blood and sputum (except the healthy control group) neutrophil oxidative phagocytic function and the expression level of related receptors of 30 healthy control groups, 30 pneumonia patients and 30 COPD patients by using FCM, and analyzing the inter-group difference. The result is as follows: compared with a healthy control group, the oxidative phagocytic function of neutrophils in peripheral blood and sputum of a COPD patient group and the expression ofa surface CCR1 receptor are obviously reduced (P is less than 0.05); compared with the pneumonia control group, the difference of oxidative phagocytic functions of neutrophils in peripheral blood hasno statistical significance, but in sputum, a COPD patient group is obviously lower than a pneumonia control group, the expression of neutrophil surface receptors CCR1 in the sputum of the COPD patient group is obviously higher than that of the pneumonia control group, and the difference has statistical significance (P is less than 0.05).

Description

technical field [0001] The invention relates to the technical field, specifically, the application of CCR1 expression as a COPD diagnostic marker. Background technique [0002] COPD is a disease characterized by airflow limitation that is not fully reversible. It is a common, frequent, and highly fatal chronic respiratory disease. It is currently one of the four major fatal diseases worldwide. So far, the exact pathogenesis of COPD is still unclear. It is generally believed that COPD is characterized by chronic inflammation of the airway, lung parenchyma and pulmonary blood vessels. The imbalance of protease and antiprotease, oxidation and antioxidant in the lungs is also involved in the pathogenesis of COPD. makes an important impact. [0003] Neutrophils (PMN) are important effector cells involved in innate immunity. PMN plays an important role in regulating inflammation and immune response through chemotactic phagocytosis, respiratory burst, secretion of decomposing enzy...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6863G01N33/6884G01N2333/7158G01N2800/12G01N2800/122G01N2800/127
Inventor 闫佩毅朱晴晖金姝张建宾张骥苏立杰
Owner SHANGHAI PUTUO DISTRICT PEOPLES HOSPITAL
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