Water-soluble haematococcus pluvialis astaxanthin soft capsules and preparation method therefor

Abstract

The invention discloses water-soluble haematococcus pluvialis astaxanthin soft capsules and a preparation method therefor. Capsule walls of the astaxanthin soft capsules comprise the ingredients in parts by mass: 100 parts of gelatin, 6 parts of citric acid, 20 parts of glycerine, 4 parts of sodium carboxymethyl cellulose, 10 parts of sorbitol and 11-13 parts of water; and capsule cores comprise the ingredients in percentage by mass: 10.0%-18.0% of haematococcus pluvialis astaxanthin oil, 10.0%-20.0% of polyethylene glycol-400, 20.0%-40.0% of mono- / bis-glyceryl unsaturated fatty acid ester, 2.0%-5.0% of sorbitol and 30.0%-45.0% of decapolyglyceryl monooleate. The preparation method for the astaxanthin soft capsules further comprises a step of carrying out high-pressure homogenizing mixingunder nitrogen protection so as to prepare the capsule cores. According to the water-soluble haematococcus pluvialis astaxanthin soft capsules and the preparation method therefor, all adjuvants employed are used by health-care foods according to production needs, an emulsifier is an unsaturated fatty acid processed product, the astaxanthin soft capsules are safe, non-toxic, compliant and legal, are low in health security risk and are suitable for an aqueous nutrient absorption system of the intestines and stomach of a human body, and the bioavailability of an active ingredient, i.e., astaxanthin can be improved.

Description

technical field

[0001] The invention relates to a Haematococcus pluvialis astaxanthin soft capsule preparation and a preparation method thereof, in particular to a water-soluble Haematococcus pluvialls astaxanthin soft capsule and a preparation method thereof. Background technique

[0002] Astaxanthin is an oxygen-containing carotenoid (Xanthophyll), which is a carotenoid containing a ketone group. Its molecular formula is C 40 h 52 o 4 , the relative molecular mass is 596.86, and the semi-systematic name (IUPAC) is 3,3-dihydroxy-β,β-carotene-4,4'-dione (3,3'-Dihydroxy-β,β-carotene-4 ,4'-dione).

[0003] The two ends of the astaxanthin molecule are β terminal groups ( figure 1 ), contains hydroxyl and ketone groups, and its central polyene chain contains 9 double bonds, which can form a variety of cis-trans isomers (E / Z isomers), but most of them are all-trans isomers (All-trans isomers) in nature E-isomer). In addition, astaxanthin has a chiral center at the 3 and 3'...

Examples

preparation example Construction

[0058] The preparation method of the water-soluble Haematococcus pluvialis astaxanthin soft capsule includes the conventional soft capsule preparation steps of melting glue, making pills, setting the shape, washing pills, drying, checking pills, testing, and packaging. First, glue is melted, and dry gelatin is measured. 0.7 to 1.4 times the mass of water, heat, add plasticizer, dissolve completely, then add gelatin, stir to dissolve, degas under negative pressure, filter to remove impurities, and obtain glue; then make pellets, which can be molded or dropped; Regardless of whether it is pressed or dripped soft capsules, it needs to be shaped, washed, and dried until the water content is below 9.0% by mass; then, the pills are inspected to remove unqualified products; finally, inspection and packaging are carried out according to product implementation standards .

[0059] In view of the fact that the capsule core of the water-soluble Haematococcus pluvialis astaxanthin soft ca...

Embodiment 1

[0063] Preparation of a water-soluble Haematococcus pluvialis astaxanthin soft capsule

[0064] 1) Capsule wall component formula (mass meter)

[0065] 100 parts of gelatin, 20 parts of glycerin, 10 parts of sorbitol, 6 parts of citric acid, 4 parts of sodium carboxymethylcellulose, 110 parts of water.

[0066] 2) Capsule core component formula (mass percentage)

[0067] Haematococcus pluvialis astaxanthin oil 10.0%, mono-diglyceride oleate (monoglyceride mass percentage ≥ 90.0) 20.0%, decaglycerol mono-oleate 45.0%, polyethylene glycol-400 20.0%, sorbose Alcohol 5.0%.

[0068] 3) glue

[0069] Measure 1.1 times the weight of dry gelatin in water, heat, add glycerin, sorbitol, citric acid, sodium carboxymethyl cellulose required for the formula, dissolve completely, then add gelatin required for the formula, stir to dissolve, degas under negative pressure, filter Remove impurities and get glue.

[0070] 4) Preparation of capsule core

[0071] First, according to the form...

Embodiment 2

[0076] Preparation of a water-soluble Haematococcus pluvialis astaxanthin soft capsule

[0077] 1) Capsule wall component formula (mass meter)

[0078] 100 parts of gelatin, 20 parts of glycerin, 10 parts of sorbitol, 6 parts of citric acid, 4 parts of sodium carboxymethylcellulose, 100 parts of water.

[0079] 2) Capsule core component formula (mass percentage)

[0080] Haematococcus pluvialis astaxanthin oil 18.0%, mono-diglyceride linoleate (monoglyceride mass percentage ≥ 90.0) 40.0%, decaglycerol mono-oleate 30.0%, polyethylene glycol-400 10.0%, Sorbet Sugar Alcohol 2.0%.

[0081] 3) glue

[0082] Measure 1.0 times the weight of dry gelatin in water, heat it, add glycerin, sorbitol, citric acid, and sodium carboxymethylcellulose required by the formula, dissolve completely, then add gelatin required by the formula, stir to dissolve, degas under negative pressure, and filter Remove impurities and get glue.

[0083] 4) Preparation of capsule core

[0084] First, accor...

technical field

[0001] The invention relates to a Haematococcus pluvialis astaxanthin soft capsule preparation and a preparation method thereof, in particular to a water-soluble Haematococcus pluvialls astaxanthin soft capsule and a preparation method thereof. Background technique

[0002] Astaxanthin is an oxygen-containing carotenoid (Xanthophyll), which is a carotenoid containing a ketone group. Its molecular formula is C 40 h 52 o 4 , the relative molecular mass is 596.86, and the semi-systematic name (IUPAC) is 3,3-dihydroxy-β,β-carotene-4,4'-dione (3,3'-Dihydroxy-β,β-carotene-4 ,4'-dione).

[0003] The two ends of the astaxanthin molecule are β terminal groups ( figure 1 ), contains hydroxyl and ketone groups, and its central polyene chain contains 9 double bonds, which can form a variety of cis-trans isomers (E / Z isomers), but most of them are all-trans isomers (All-trans isomers) in nature E-isomer). In addition, astaxanthin has a chiral center at the 3 and 3'...

Examples

preparation example Construction

[0058] The preparation method of the water-soluble Haematococcus pluvialis astaxanthin soft capsule includes the conventional soft capsule preparation steps of melting glue, making pills, setting the shape, washing pills, drying, checking pills, testing, and packaging. First, glue is melted, and dry gelatin is measured. 0.7 to 1.4 times the mass of water, heat, add plasticizer, dissolve completely, then add gelatin, stir to dissolve, degas under negative pressure, filter to remove impurities, and obtain glue; then make pellets, which can be molded or dropped; Regardless of whether it is pressed or dripped soft capsules, it needs to be shaped, washed, and dried until the water content is below 9.0% by mass; then, the pills are inspected to remove unqualified products; finally, inspection and packaging are carried out according to product implementation standards .

[0059] In view of the fact that the capsule core of the water-soluble Haematococcus pluvialis astaxanthin soft ca...

Embodiment 1

[0063] Preparation of a water-soluble Haematococcus pluvialis astaxanthin soft capsule

[0064] 1) Capsule wall component formula (mass meter)

[0065] 100 parts of gelatin, 20 parts of glycerin, 10 parts of sorbitol, 6 parts of citric acid, 4 parts of sodium carboxymethylcellulose, 110 parts of water.

[0066] 2) Capsule core component formula (mass percentage)

[0067] Haematococcus pluvialis astaxanthin oil 10.0%, mono-diglyceride oleate (monoglyceride mass percentage ≥ 90.0) 20.0%, decaglycerol mono-oleate 45.0%, polyethylene glycol-400 20.0%, sorbose Alcohol 5.0%.

[0068] 3) glue

[0069] Measure 1.1 times the weight of dry gelatin in water, heat, add glycerin, sorbitol, citric acid, sodium carboxymethyl cellulose required for the formula, dissolve completely, then add gelatin required for the formula, stir to dissolve, degas under negative pressure, filter Remove impurities and get glue.

[0070] 4) Preparation of capsule core

[0071] First, according to the form...

Embodiment 2

[0076] Preparation of a water-soluble Haematococcus pluvialis astaxanthin soft capsule

[0077] 1) Capsule wall component formula (mass meter)

[0078] 100 parts of gelatin, 20 parts of glycerin, 10 parts of sorbitol, 6 parts of citric acid, 4 parts of sodium carboxymethylcellulose, 100 parts of water.

[0079] 2) Capsule core component formula (mass percentage)

[0080] Haematococcus pluvialis astaxanthin oil 18.0%, mono-diglyceride linoleate (monoglyceride mass percentage ≥ 90.0) 40.0%, decaglycerol mono-oleate 30.0%, polyethylene glycol-400 10.0%, Sorbet Sugar Alcohol 2.0%.

[0081] 3) glue

[0082] Measure 1.0 times the weight of dry gelatin in water, heat it, add glycerin, sorbitol, citric acid, and sodium carboxymethylcellulose required by the formula, dissolve completely, then add gelatin required by the formula, stir to dissolve, degas under negative pressure, and filter Remove impurities and get glue.

[0083] 4) Preparation of capsule core

[0084] First, accor...

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