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Nano realgar and its preparation

A realgar and nano-technology, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of lack of processing methods, difficult drug efficacy, and low bioavailability of drugs

Inactive Publication Date: 2003-07-30
HUAZHONG UNIV OF SCI & TECH
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  • Claims
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AI Technical Summary

Problems solved by technology

However, the pharmacological effects of traditional Chinese medicine cannot be solely attributed to the unique chemical composition of the drug, and may also be closely related to the physical state of the drug.
Due to the lack of advanced processing methods in traditional Chinese medicine processing methods, the bioavailability of many drugs is low, and it is difficult to fully exert their efficacy

Method used

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  • Nano realgar and its preparation
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Experimental program
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Effect test

Embodiment Construction

[0007] Take nano powder realgar and common realgar powder for drug effect comparison experiment. In the following two experiments, several realgar powder samples with different particle sizes were prepared from realgar, with the purpose of studying the influence of the particle size of the powder, especially the nanoscale, on its pharmacological effects. Experiment (1) on mouse sarcoma S 180 Study on Inhibition of Tumor Cells in Vitro

[0008] Materials for this experiment: realgar was purchased from the pharmacy of Hubei Academy of Traditional Chinese Medicine, Kunming white mice (about 20g), S 180 All tumor-bearing mice were purchased from the Experimental Animal Center of Tongji Medical University. The experimental method:

[0009] 1. Obtained three kinds of realgar powder samples with different particle sizes by the above-mentioned preparation method, and its average particle size is respectively 500nm (No. I sample), 200nm (No. II sample) and <100nm (No. III sample). ...

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Abstract

The present invention relates to a preparation method of nanomater realgar, i,e, the Chinese medicine realgar is made into nanometer-level (1-100 nanometers) fine powder to raise the medicinal effect and tumor-resisting action of Chinese medicine realgar. The method for implementing said invention includes: (1) temp.-controllable vacuum or inert atmosphere high-energy ball grinding method; and (2) supersonic airflow pulverizing method.

Description

technical field [0001] What the present invention relates to is traditional Chinese medicine and preparation method thereof. Introduce nanotechnology to the preparation of realgar, a traditional Chinese medicine, that is, make realgar into nano-scale fine powder, so as to endow realgar with higher efficacy. Nanotechnology refers to the research and application on the material scale of 0.1-100 nanometers (nanometer, nanometer for short). Background technique [0002] Mineral traditional Chinese medicine realgar, the main component is arsenic disulfide (As 2 S 2 ). The functions and indications of realgar are to detoxify and kill insects, dry dampness and expel phlegm, cut off malaria, and be used for carbuncle and furuncle, snake and insect bites, abdominal pain caused by parasites, epilepsy, malaria, etc. Modern pharmacological studies have shown that realgar has anti-pathogenic microorganisms and anti-tumor effects. [0003] Realgar is insoluble in water, and it is gen...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K33/36A61P35/00
Inventor 谢长生杨祥良徐辉碧吴隽黄开勋邓英吴际洲金满文
Owner HUAZHONG UNIV OF SCI & TECH