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Biomarkers and their applications for early diagnosis and/or recurrence monitoring of glioma

A biomarker and glioma technology, applied in the field of biomarkers for early diagnosis and/or recurrence monitoring of glioma, to achieve the effect of convenient and easy diagnosis, rapid and accurate diagnosis method, and high diagnostic value

Active Publication Date: 2022-06-03
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the diagnosis and liquid biopsy of CSF exosomes have been rarely reported so far

Method used

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  • Biomarkers and their applications for early diagnosis and/or recurrence monitoring of glioma
  • Biomarkers and their applications for early diagnosis and/or recurrence monitoring of glioma
  • Biomarkers and their applications for early diagnosis and/or recurrence monitoring of glioma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

1, the identification screening of molecular marker in cerebrospinal fluid exosome:

Through the above-mentioned whole transcriptome detection, it is found that only the expression amount of miRNA in the cerebrospinal fluid exosome is stable and reliable, and is not affected by

Preoperative and postoperative status, tumor and non-tumor, and interindividual differences were the best markers for CSF liquid biopsy (Fig.

2). The expression level of miRNA is the highest, and the difference between individuals is the smallest, and the overall expression level is the most stable

2. Only miRNA in cerebrospinal fluid exosomes can be used as liquid biopsy molecular marker for early diagnosis of glioma

By contrasting various cerebrospinal fluid exosome indexes such as miRNA, mRNA, lncRNA and circRNA, it was found that only

Some miRNAs can accurately distinguish the cerebrospinal fluid of tumor patients from normal control cerebrospinal fluid, while the rest of the RNA indicators c...

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Abstract

The invention provides a biomarker for early diagnosis and / or recurrence monitoring of glioma and its application, and belongs to the technical field of molecular diagnosis and molecular biology. The study of the present invention found that the relative expression levels of various miRNAs in cerebrospinal fluid exosomes were significantly correlated with the occurrence of glioma, among which 102 miRNAs were significantly up-regulated in cerebrospinal fluid exosomes of patients with glioma, and 167 miRNAs were significantly down-regulated All of these miRNAs and their marker profiles containing 269 miRNAs have high diagnostic value. Each of the above 269 miRNAs can be used as a biomarker of glioma alone, and the collection of their marker profiles has higher diagnostic value. After combined application, it will provide a fast and accurate diagnostic method for clinical diagnosis and make the diagnosis and recurrence of glioma more difficult. Detection is more convenient and easy.

Description

Biomarkers for early diagnosis and / or recurrence monitoring of glioma and the same application technical field The invention belongs to molecular diagnosis and molecular biology technical field, be specifically related to for early diagnosis of glioma and / or biomarkers for recurrence monitoring and their applications. Background technique [0002] The information disclosed in this Background section is only for enhancement of understanding of the general background of the invention and is not necessarily be deemed to acknowledge or imply in any form that this information constitutes prior art already known to those of ordinary skill in the art technique. Human glioma is the most common malignant tumor of the central nervous system, although its prognosis depends on a variety of factors and diagnosis. However, in general, the survival time of grade III patients is 2-3 years, and the survival time of grade IV patients is only about one year. malignant glioma The c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886G16B30/10C12Q2600/178C12Q2600/158C12Q2600/118
Inventor 薛皓李刚赵荣荣郭钦栋李柏延靳传娣李江冰薛付忠刘宏桑元华
Owner SHANDONG UNIV QILU HOSPITAL