Rapid analysis method of Xingnaojing injection based on ultraviolet spectrum

A Xingnaojing injection, rapid analysis technology, applied in the analysis of materials, color/spectral property measurement, material separation and other directions, can solve problems such as less application in industrial production, achieve low cost, reduce product quality defects and quality differences , the effect of improving production efficiency

Pending Publication Date: 2020-09-29
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

Analysis methods for the production process of Xing...

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  • Rapid analysis method of Xingnaojing injection based on ultraviolet spectrum
  • Rapid analysis method of Xingnaojing injection based on ultraviolet spectrum
  • Rapid analysis method of Xingnaojing injection based on ultraviolet spectrum

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Embodiment 1

[0014] Example 1, using a rapid analysis method for the production process based on ultraviolet spectroscopy established by the present invention to monitor the extraction of Chinese medicine components under different process conditions. In order to expand the variation range of the content of each component in the sample, and to investigate whether the established analytical method is applicable under abnormal extraction conditions, six abnormal batch extraction experiments were carried out, and the changes to the extraction conditions are shown in Table 1. Batch 11 medicinal material particle size is abnormal (10-20 mesh), batch 12 medicinal material was not soaked before extraction, batch 13 and 14 extraction solvents were abnormal, batch 15 medicinal material input amount was wrong, and batch 16 heating power was abnormal. A total of 16 batches of experiments were carried out, and 166 samples were taken. The testing methods for each batch are as follows:

[0015] Acetoni...

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Abstract

The invention discloses a rapid analysis method of Xingnaojing injection based on an ultraviolet spectrum. The method is characterized in that acetonitrile is used as a mobile phase A, 0.1 wt% phosphoric acid-aqueous solution is used as a mobile phase B for linear gradient elution, and an elution procedure is 0 min, 30% A; 10min, 55%A; 24min, 55%A; 24.1min, 70%A; 35min, 70%A; 40min, 100%A; a flowrate is 0.6 mL/min, a column temperature is 40 DEG C, a sample size is 50 [mu]L, and a PDA detection wavelength range is 200-400 nm; and the detection wavelength of each component is as follows: isophorone with the wavelength of 238 nm; 4-methylene-isophorone with the wavelength of 275nm; curcuma zedoary bicyclo-enone with the wavelength of 256 nm; curcumenol with the wavelength of 261 nm; curcumazedoary diketone with the wavelength of 220 nm; curcumenone with the wavelength of 274 nm; curcuma zedoary furandienone with the wavelength of 274 nm; curcumenol with the wavelength of 210 nm; and germacrone with the wavelength of 210 nm. The analysis method established by the invention has advantages of rapidness, simplicity, convenience and low cost, and can be used for monitoring an extractionprocess and judging an extraction end point so that production efficiency is improved, and product quality defects and quality differences are reduced.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine production, in particular to a rapid analysis method for Xingnaojing injection based on ultraviolet spectroscopy. Background technique [0002] At present, the research on rapid analysis methods for the production process of Xingnaojing Injection mainly focuses on testing the quality of finished products and determining bioactive components such as sesquiterpenoids. The analytical methods for the production process of Xingnaojing Injection are seldom used in industrial production. Ultraviolet spectroscopy is a fast, non-destructive analytical method with the advantages of high sensitivity and inexpensive instrumentation. In order to reasonably judge the end point of the extraction process and improve the quality monitoring level of the production process, the present invention establishes a rapid analysis method for the production process of Xingnaojing injection based on ultraviolet s...

Claims

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Application Information

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IPC IPC(8): G01N21/33G01N30/02G01N30/06
CPCG01N21/33G01N30/02G01N30/06
Inventor 方金阳魏丹妮
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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