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Traditional Chinese medicine composition for treating gout as well as preparation method and application thereof

The technology of a composition and a pharmaceutical preparation is applied in the field of traditional Chinese medicine composition for treating gout and its preparation field, which can solve the problems of many adverse reactions, high toxicity of colchicine, pain of patients, etc. The effect of lowering blood uric acid levels

Active Publication Date: 2020-10-13
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, colchicine is highly toxic and has many adverse reactions, which can cause nausea, vomiting, diarrhea and other symptoms
Combined with other non-steroidal anti-inflammatory drugs, such as ibuprofen, diclofenac diethylamine, etc., as the treatment drugs to relieve the inflammation of acute attack of gout, after the acute symptoms are relieved, supplemented with urate-lowering drugs for uric acid-lowering treatment, non-steroidal anti-inflammatory drugs It will also cause more complications and adverse reactions, and bring greater pain to patients.

Method used

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  • Traditional Chinese medicine composition for treating gout as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating gout as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating gout as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] This embodiment provides a Chinese medicine composition for the treatment of gout, said Chinese medicine composition contains the following components by weight: 8 parts of angelica, 6 parts of Chuanxiong, 22 parts of viola, 22 parts of dandelion, 6 parts of Xia Wu Achyranthes bidentata 8 parts, Desmodium 12 parts, Notopterygium 6 parts, Myrobalan 6 parts, catechu 2 parts.

[0027] The Chinese medicine composition is prepared by the following method:

[0028] (1) After mixing and pulverizing the above-mentioned traditional Chinese medicine components into coarse powder, put it into the extraction equipment;

[0029] (2) Add 10, 8, and 6 times the amount of water in turn, heat and reflux three times, 1.5 hours each time, combine the extracts and filter, concentrate under reduced pressure at 60°C to a fluid extract with a relative density of 1.35, and dry under reduced pressure and vacuum at 65°C , and pulverized to obtain extract powder, to obtain the present Chinese me...

Embodiment 2

[0031] This example provides a traditional Chinese medicine composition for treating gout, which contains the following components in parts by weight: 12 parts of angelica, 10 parts of Chuanxiong, 30 parts of viola, 30 parts of dandelion, 9 parts of Xia Wu 12 parts of Achyranthes bidentata, 15 parts of Desmodium, 10 parts of notopterygium, 10 parts of myrobalan and 3 parts of catechu.

[0032] The Chinese medicine composition is prepared by the following method:

[0033] (1) After the above-mentioned Chinese medicine components are mixed and pulverized into coarse powder, put into the container for extraction;

[0034] (2) Add 10, 8, and 6 times the amount of 50% ethanol solution in sequence, heat and reflux for extraction three times, each time for 2.0 hours, combine the extracts and filter, condense under reduced pressure at 60°C to form a liquid extract with a relative density of 1.35, and store at 65°C Drying under reduced pressure and vacuum, and pulverizing to obtain ex...

Embodiment 3

[0036] This embodiment provides a Chinese medicine composition for treating gout, which contains the following components in parts by weight: 6 parts of Angelica sinensis, 3 parts of Rhizoma Chuanxiong, 15 parts of Viola chinensis, 15 parts of Dandelion, 3 parts of Xia Wu 5 parts of Achyranthes bidentata, 10 parts of Desmodium, 3 parts of Notopterygium, 3 parts of Myrobalan and 1 part of Catechu.

[0037] The Chinese medicine composition is prepared by the following method:

[0038] (1) After the above-mentioned Chinese medicine components are mixed and pulverized into coarse powder, put into the container for extraction;

[0039] (2) Add 10, 8, and 6 times the amount of water in turn, heat and reflux three times, 1.5 hours each time, combine the extracts and filter, concentrate under reduced pressure at 60°C to a fluid extract with a relative density of 1.25, and dry under reduced pressure and vacuum at 65°C , crushed to obtain extract powder, add dextrin at a ratio of 1:1 (...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating gout as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 6 to 12 parts of radix angelicae sinensis, 3 to 10 parts of rhizoma chuanxiong, 15 to 30 parts of herba violae, 15 to 30 parts of herba taraxaci, 3 to9 parts of rhizoma corydalis decumbentis, 5 to 12 parts of radix achyranthis bidentatae, 10 to 15 parts of herba lysimachiae, 3-10 parts of notopterygium root, 3-10 parts of Terminalia chebula Retz and 1-3 parts of catechu. The traditional Chinese medicine composition can relieve red, swollen and hot pain in the acute attack period of gout, reduce the blood uric acid level, effectively control recurrence of gout and reduce the occurrence probability of other complications, and various adopted traditional Chinese medicine raw materials are simple and easy to obtain. The traditional Chinese medicine composition for treating acute attack of treatment gout can be obtained through simple extraction and concentration, the preparation process is simple, after different auxiliary materials are added, different dosage forms of agents for treating acute attack of treatment gout can be prepared, and the traditional Chinese medicine composition has important significance on acute attack of treatment gout.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and more specifically relates to a traditional Chinese medicine composition for treating gout, a preparation method and application thereof. Background technique [0002] Gout is a heterogeneous chronic metabolic disease caused by purine metabolism disorder or uric acid excretion disorder caused by various reasons, also known as hyperuricemia. Gout is divided into acute gout and chronic gout according to clinical symptoms. Acute gout attacks suddenly and can be induced by trauma, surgery, excessive drinking, etc., and the clinical manifestation is gouty arthritis. Restricted joint movement seriously affects normal life. At present, the pathogenesis of gout has not been fully revealed, and it still cannot be completely cured. Long-term comprehensive treatment is mainly based on the combination of uric acid-lowering, anti-inflammatory and pain-relieving drugs, and diet control...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61P19/06
CPCA61K36/185A61K36/21A61K36/232A61K36/236A61K36/237A61K36/288A61K36/48A61K36/53A61K36/66A61K36/86A61K2236/331A61K2236/333A61K2236/51A61P19/06A61K2300/00
Inventor 冯育林李志峰游梦黄文平王琦杨世林钟国跃
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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