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Pharmaceutical composition comprising an antiparasitic drug and an active ingredient selected from carveol, thymol, eugenol, camphor, carvacrol, alpha-ionone or beta-ionone

An anti-parasite and thymol technology, applied in the direction of drug combination, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc., can solve the problems of life quality impact, difficult treatment of patients, shortened life expectancy, etc., to reduce cost effect

Inactive Publication Date: 2011-12-28
ADVANCED SCIENTIFICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For example, immunosuppressed patients in particular will become increasingly difficult to treat and their life expectancy will be correspondingly shortened
In addition, their quality of life is also greatly affected due to the high doses of therapeutic drugs given

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0064] Example 1: Treatment of chicken balls with carvacrol or thymol synergistic salinomycin Bug disease

[0065] These in vivo experiments were designed to measure weight gain, wasting index, daily cyst shedding and fecal appearance in treated birds.

[0066] The subjects of this experiment were 200 22-day-old subclinical coccidiosis chickens (average weight 620 g), sampled from a flock of 10,000 broilers. Subclinical coccidiosis was diagnosed on day 20. The mean cyst shedding in this experimental animal was 50,000 cysts / g (OPG).

[0067] Microscopic examination revealed the presence of two Eimeria genera: Eimeria acervulina and Eimeria tenella.

[0068] The antiparasitic used was salinomycin, one of the most widely prescribed antiparasitics for this type of infection. The two antiparasitic pharmaceutical compositions according to the present invention are prepared by mixing different concentrations of salinomycin with sub-inhibitory concentrations of carvacrol or thym...

example 2

[0087] Example 2: Intrinsic antimalarial effects of eugenol and carvacrol and synergistic effect of artesunate

[0088] In vitro test: IC 50 (Concentration required for 50% inhibition of parasite growth) Determination

[0089] The experiments were performed in 4 clones (designated 3d7, HB3, Dd2 and 7G8) of the malaria pathogen Plasmodium falciparum, a parasitic disease also known as malaria. These clones are laboratory reference models commonly used to screen drugs for antimalarial activity.

[0090] Plasmodium falciparum grows on human red blood cells. The assay is performed in 96-well plates in which infected erythrocytes (synchronized with sorbitol) are incubated at 37°C under gas-controlled (5% CO 2 , 1% O 2 ,,94%N 2 ) received different treatments for 72 hours in an incubator. Pathogen growth is measured by quantifying fluorescent DNA in the presence of SybrGreen.

[0091] One of the most effective antiparasitic drugs, artesunate, was tested. The antiparasitic p...

example 3

[0103] Example 3: Intrinsic antimalarial effect of eugenol and synergistic effect of chloroquine.

[0104] In vitro test: IC 50 Determination of (concentration required for 50% inhibition of parasite growth)

[0105] This experiment was carried out in the same Plasmodium falciparum clones (3d7, HB3, Dd2 and 7G8) as in Example 2, the first two clones (3d7 and HB3) were sensitive to chloroquine and the other two (Dd2 and 7G8) were sensitive to chloroquine drug resistance.

[0106] One of the most widely used antiparasitic drugs, chloroquine, was tested. The antiparasitic pharmaceutical composition according to the present invention is prepared by mixing different concentrations of chloroquine with sub-inhibitory concentrations of 0.2mM eugenol, which is higher than the IC of eugenol alone. 50 2 to 6-fold lower (depending on clone). The pharmaceutical composition is named as chloroquine-eugenol, and the letter P represents the synergistic effect of eugenol.

[0107] In eac...

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PUM

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Abstract

The present invention relates to a pharmaceutical composition comprising at least one first active therapeutic substance selected from the group consisting of carveol, thymol, eugenol, camphor, carvacrol, α-ionone, β-ionone and isomers, derivatives and mixtures thereof; and comprising at least one second active therapeutic substance which is an antiparasitic drug, in particular an antimalarial drug . The invention is applied in the pharmaceutical field.

Description

technical field [0001] The present invention relates to a pharmaceutical composition comprising two therapeutically active substances, one of which exerts a synergistic effect on the other; and to the use of this composition. Background technique [0002] It is known that the effect of therapeutic drugs depends on the dose used, and in the case of partial drug resistance, it is necessary to increase the dose of therapeutic drugs in order to achieve the desired effect. Dosage increases lead to problems of adverse reactions and acute or chronic toxicity, which can greatly complicate the condition of the treated patient. [0003] This partial resistance may become complete resistance. In this case, increasing the dose no longer had any beneficial therapeutic effect; only toxic effects were observed. Treatment in this case consists in changing the medication. [0004] This chain of events is itself repeatable and leads to the most severe scenario: complete resistance to multi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P31/12A61P33/00A61P33/10A61P35/00A61K45/06A61K31/045A61K31/05
CPCA61K31/05A61K45/06A61K31/045A61P31/12A61P33/00A61P33/10A61P35/00Y02A50/30A61K2300/00
Inventor 阿德南·雷梅尔
Owner ADVANCED SCIENTIFICS INC
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