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Combined diagnosis model and system for early breast cancer

A diagnostic model and technology for breast cancer, which is applied in the field of combined diagnostic models and systems for early breast cancer, can solve the problems of low ctDNA abundance and imperfect detection technology, and achieve good clinical application prospects and high specificity

Active Publication Date: 2020-10-30
WENZHOU INST UNIV OF CHINESE ACAD OF SCI +3
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Problems solved by technology

However, the abundance of ctDNA in the peripheral blood of breast cancer patients, especially early breast cancer patients, is low, and the detection technology is not perfect. More in-depth research is needed for the clinical application of ctDNA detection

Method used

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  • Combined diagnosis model and system for early breast cancer
  • Combined diagnosis model and system for early breast cancer
  • Combined diagnosis model and system for early breast cancer

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Experimental program
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Embodiment

[0056] 1. Research object

[0057] Select from April 1, 2019 to August 31, 2019 in Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College Hospital (CHCAMS, n = 160, training set) and Cancer Hospital Affiliated to Harbin Medical University (HMUCH, n = 50, validation set ) 210 cases of BI-RADS4 lesions found by conventional ultrasonography, all patients were female, all patients underwent mammography and ultrasonography, and all patients were confirmed by surgery or biopsy pathological examination. In this study, the age, imaging appearance, pathological features, molecular subtype, stage and serum tumor markers such as carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) of the patients in the training set and validation set were compared. Perform phenotypic analysis. Two experienced radiologists at each center interpreted images and classified them according to the fifth edition of the BI-RADS classification. CEA and CA15-3 analyze...

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Abstract

The invention discloses a combined diagnosis model and system for early breast cancer. The combined diagnosis model comprises a parameter cfDNA differential methylation area marker, ultrasonic examination and molybdenum target X-ray examination. The combined diagnosis model is constructed by adopting an LASSO method, and a breast cancer patient can be effectively judged.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a combined diagnosis model and system for early breast cancer. Background technique [0002] Breast cancer is one of the most important malignant tumors in my country, and it is also the most common malignant tumor in women. It ranks 4th, 4th and 5th in the ranking of female malignant tumor deaths in the eastern, central and western regions, respectively. Bit (Sun Kexin, Zheng Rongshou, Zhang Siwei, etc. Analysis of the incidence and mortality of malignant tumors in different regions in China in 2015 [J]. Chinese Oncology, 2019, 28(01): 1-11.). Early treatment is beneficial to improve the survival rate of patients, therefore, early detection and diagnosis of breast cancer is of great significance. Since the early clinical symptoms and signs of breast cancer are usually without obvious specificity, it is generally not easy to be found clinically, so imaging examination has become an import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/20G16H50/70G16B40/00C12Q1/6886
CPCG16H50/20G16H50/70G16B40/00C12Q1/6886C12Q2600/154C12Q2600/178
Inventor 苏建忠刘嘉琦赵恒强许守平吴南黄宇宽
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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