A kind of anti-hair loss shampoo and preparation method

A technology for preventing hair loss and regenerating shampoo, applied in the field of shampoo, can solve the problem of insignificant effect, etc., and achieve the effect of enhancing activity

Inactive Publication Date: 2021-04-20
山茶元素(北京)科技研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The current market hair growth and hair care shampoo effect is not obvious

Method used

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  • A kind of anti-hair loss shampoo and preparation method
  • A kind of anti-hair loss shampoo and preparation method
  • A kind of anti-hair loss shampoo and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 1 Extraction of functional ingredients

[0064] Salvia miltiorrhiza: crush the Chinese medicinal material salvia miltiorrhiza, and pass through a 30-mesh sieve. Weigh 40 g of Salvia miltiorrhiza powder, add ethanol 10 times the weight of the original medicinal material, heat and reflux for extraction for 6 hours. Filter the extract, repeat the extraction of the residue twice, combine the extracts, filter and concentrate to a paste. Add 4 times the weight of the original medicinal material to the extract to dissolve the extract, and filter to obtain the salvia miltiorrhiza extract (liquid state). Crude drug concentration 0.25g / mL.

[0065] Angelica sinensis: crush the traditional Chinese medicine Angelica sinensis, and pass through a 30-mesh sieve. Weigh 40 g of angelica powder, add water 10 times the weight of the original medicinal material, heat and reflux for extraction for 6 hours. Filter the extract, repeat the extraction of the residue twice, combine the extra...

experiment example 1

[0074] Experimental example 1 Functional component experiment

[0075] Functional ingredients: the functional ingredients are Danshen extract, Angelica sinensis extract, Safflower extract, Astragalus extract, Polygonum multiflorum extract and Camellia oleifera polypeptide obtained in Example 1.

[0076] Proportions of functional ingredients: the weight ratio of salvia miltiorrhiza extract, angelica extract, safflower extract, astragalus extract, Polygonum multiflorum extract and Camellia oleifera polypeptide is 1:1:2:1:5:0.1.

[0077] Efficacy: Improve the activity of hair papilla cells

[0078] Experimental data: Taking dermal papilla cells as the experimental object, stimulated with a certain concentration of dihydrotestosterone to establish an in vitro cell model of androgenetic alopecia, treated with minoxidil as a control, and then treated the in vitro model of androgenetic alopecia with functional ingredients, passed the test Proliferation activity of dermal papilla cel...

experiment example 2

[0087] Experimental example 2 Shampoo experiment

[0088] Take the patients with alopecia and thinning hair as observation objects, and use the shampoo prepared in Example 1 every 3 days. Observe the amount of hair loss or hair loss in areas of thinning hair and observe how thick the hair is in the area.

[0089] When the hair becomes thicker, it is cured, if the number of hair loss is reduced, it is effective, and if the number of hair loss does not increase, it is effective.

[0090] Alopecia, thinning hair patients are selected 30 people. The effective rate is 85% for patients with hair loss and 98% for patients with thinning hair.

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Abstract

The invention discloses a shampoo for preventing hair loss and a preparation method thereof. The shampoo includes active ingredients, including salvia miltiorrhiza extract, angelica extract, safflower extract, astragalus extract, Polygonum multiflorum extract, and camellia seed polypeptide. The active ingredient composed of the salvia miltiorrhiza extract, the angelica extract, the safflower extract, the astragalus extract, the Polygonum multiflorum extract and the camellia seed polypeptide can enhance the activity of the dermal papilla cells after being treated with dihydrotestosterone. In vitro experiments showed that the secretion factors of dermal papilla cells, such as IGF‑1, VEGF, DKK‑1, TGFβ1, TGFβ2, IL‑6, etc., as well as β‑catenin and AR, all returned to normal levels. Patients with alopecia and thinning hair use the shampoo of the present invention once every 3 days. The effective rate is 85% for patients with hair loss and 98% for patients with thinning hair.

Description

technical field [0001] The invention belongs to the field of shampoos, and relates to a shampoo for preventing and growing hair and a preparation method thereof. Background technique [0002] The effect of hair growth and hair care shampoo in the market is not obvious. After the folk tea seeds are boiled and shampooed, the hair will be black and bright, and the hair will be thick. Polygonum multiflorum is a common traditional Chinese medicine for black hair and black hair. [0003] Androgenetic alopecia and alopecia areata are two common types of hair loss. Androgenetic alopecia is mainly induced by high levels of dihydrotestosterone in the hair follicles, while alopecia areata is mainly induced by autoimmunity. The molecular mechanism of male genetic hair loss treatment mainly includes (1) targeting the conversion stage of androgen to dihydrotestosterone, mainly inhibiting the activity of 5α reductase, thereby inhibiting the content of dihydrotestosterone in the body; (2)...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/9789A61Q5/02A61Q7/00
CPCA61K8/645A61K2800/5922A61Q5/02A61Q7/00A61K8/9789
Inventor 何礼明
Owner 山茶元素(北京)科技研发有限公司
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