Ophthalmic liposome capable of penetrating cornea and targeting retina, preparation method and application thereof

An ophthalmic liposome and liposome technology, which is applied in the field of medicine, can solve the problems of not being able to effectively improve the fluidity of the vitreous body and targeting the retina, poor fluidity of the unimproved carrier, and large eye irritation, etc., to achieve Strengthen the corneal penetration effect, improve medication compliance, and increase the penetration effect
CN111888484BActive Publication Date: 2021-07-27GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO LTD
Publication Date
2021-07-27

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Abstract

The invention relates to an ophthalmic liposome capable of penetrating the cornea and targeting the retina, its preparation method and application. The ophthalmic liposome is a kind of liposome composed of lipid material with good biocompatibility, loaded with anti-VEGF drug and connected with cell penetrating peptide CPP and hyaluronic acid HA on the surface. The present invention loads the anti-VEGF drug inside the liposome, which effectively improves the shortcoming of the poor stability of the anti-VEGF drug. At the same time, the amphiphilicity of the liposome is used to enhance the corneal penetration effect, and the surface is covalently connected with a cell-penetrating liposome. Penetrant CPP and retina-targeted hyaluronic acid HA, found that the prepared liposomes can significantly increase the corneal penetration and accumulation of the drug to the fundus through eye drops, thereby increasing the concentration of the drug in the lesion , significantly improving the healing effect.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to an ophthalmic liposome co-modified with a cell penetrating peptide CPP and hyaluronic acid HA capable of penetrating the cornea and targeting the retina, and a preparation method and application thereof. Background technique

[0002] The eye is an extremely complex and precise organ, anatomically divided into two parts: the anterior segment and the posterior segment. The anterior segment mainly includes the cornea, conjunctiva, aqueous humor, and lens, and the posterior segment mainly includes the vitreous, sclera, choroid, and retina. Intraocular neovascular diseases are mainly located in the posterior segment of the eye, such as retinopathy of prematurity (ROP), diabetic retinopathy (Diabetic retinopathy, DR) and age-related macular degeneration (Age-related macular degeneration, AMD), It is a serious blinding eye disease. Fundus neovascular diseases include chor...

Claims

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