Collagen multifunctional absorbable medical suture line and preparation method thereof

A collagen and collagen fiber technology, applied in the field of collagen suture processing, can solve the problems of absorbable protein thread rejection, high toxicity of chromium ions, residual chromium ions, etc., achieve green environmental protection efficiency and improve decolorization efficiency , Knotted firm effect

Inactive Publication Date: 2020-11-10
NEW MATERIAL INST OF SHANDONG ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, collagen sutures have the following problems: low strength and high absorbability, resulting in the use of multiple continuous sutures for absorbable protein threads and often requiring secondary sutures; incision infection, because the protein thread is sutured in the dermis , some patients will have a rejection reaction to the absorbable protein thread, causing redness and swelling of the incision, exudate, etc.
However, the toxicity of chromium ions is high, and a large amount of chromium ions remain in the wastewater during the tanning process, causing great pollution to the environment
In addition, chromium-containing sutures are used in human tissues, and there are potential safety risks

Method used

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  • Collagen multifunctional absorbable medical suture line and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0036] A collagen multifunctional absorbable medical suture and a preparation method thereof, comprising the following steps:

[0037] (1) Compound lipase degreasing treatment: Put fresh goat casings or green goat casings or black goat casings or small-tailed Han sheep casings into a solution composed of neutral lipase, enzyme activator calcium chloride and surfactant PEG400. Soak in a container of the mixed treatment solution, the soaking temperature is 30° C., and the soaking time is 2.5 hours to obtain the crude defatted collagen fiber.

[0038] (2) Ultrasonic-enhanced degreasing: Clean the crude degreased collagen fibers with water, put them into 0.9% sodium chloride solution and place them in an ultrasonic device, keep the temperature at 30°C, and carry out continuous ultrasonic radiation. The ultrasonic frequency is 49KHz. The time is 0.75h to obtain defatted collagen fibers.

[0039] (3) Composite catalase decolorization: clean the defatted collagen fibers with clear w...

Embodiment 2

[0044] A collagen multifunctional absorbable medical suture and a preparation method thereof, comprising the following steps:

[0045] (1) Compound lipase degreasing treatment: put fresh goat casings or green goat casings or black goat casings or small-tailed Han sheep casings into a mixture of neutral lipase, enzyme activator calcium chloride and surfactant polyoxyethylene Soak in a container of the mixed treatment solution composed of the solution, the soaking temperature is 25° C., and the soaking time is 3 hours to obtain the crude defatted collagen fiber.

[0046] (2) Ultrasonic enhanced degreasing: clean the crude collagen fibers with clear water, put them into 0.9% sodium chloride solution and place them in an ultrasonic device, keep the temperature at 25°C, and carry out continuous ultrasonic radiation. The ultrasonic frequency is 24.5KHz. The irradiation time was 2h to obtain defatted collagen fibers.

[0047] (3) Compound catalase decolorization: clean the degreased...

Embodiment 3

[0052] A collagen multifunctional absorbable medical suture and a preparation method thereof, comprising the following steps:

[0053] (1) Compound lipase degreasing treatment: put fresh goat casings or green goat casings or black goat casings or small-tailed Han sheep casings into a solution containing alkaline lipase, enzyme activator calcium sulfate and surfactant polyoxypropylene solution. soaking in a container of the mixed treatment solution, the soaking temperature is 25° C., and the soaking time is 3 hours to obtain the crude defatted collagen fiber.

[0054] (2) Ultrasonic-enhanced degreasing: clean the crude degreased collagen fiber with water, put it into 0.9% sodium chloride solution and place it in an ultrasonic device, keep the temperature at 25°C, and carry out continuous ultrasonic radiation. The ultrasonic frequency is 98KHz. The defatted collagen fibers were obtained after 1 h.

[0055] (3) Compound catalase decolorization: clean the degreased collagen fiber...

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Abstract

The invention relates to a collagen multifunctional absorbable medical suture line and a preparation method thereof. The preparation method of the collagen multifunctional absorbable medical suture line comprises the following steps of: (1) compound lipase degreasing; (2) ultrasonic enhanced degreasing; (3) compound catalase decoloration; (4) ultrasonic enhanced decolorization; (5) nano and biological function composite tanning; and (6) drying and sterilization. The collagen multifunctional absorbable medical suture line prepared with the method has the advantages of being high in tensile strength, controllable in absorption time, firm to knot, good in biocompatibility, free of adverse reactions in the human body and lasting in antibacterial performance. According to the preparation method, degreasing and decolorization are performed by using a composite biological enzyme process and an ultrasonic enhanced process, so that the method is environment-friendly and high in degreasing and decolorization efficiency; the tensile strength of the collagen medical suture line is greatly enhanced through nano and biological function composite tanning; the absorption time of the suture line inthe body is controllable; and the collagen medical suture line has the lasting antibacterial performance.

Description

technical field [0001] The invention relates to a collagen multifunctional absorbable medical suture and a preparation method thereof, belonging to the technical field of collagen suture processing. Background technique [0002] Collagen suture is a kind of absorbable medical surgical suture. It is a natural absorbable suture made from animal collagen. It is unparalleled in the field of surgical suture because it can be degraded by the human body, easy to operate, and has no toxic side effects. The advantage of this product has received more and more attention and has become the development direction of medical sutures. [0003] At present, collagen sutures have the following problems: low strength and high absorbability, resulting in the use of multiple continuous sutures for absorbable protein threads and often requiring secondary sutures; incision infection, because protein threads are sutured in the dermis , Some patients will have a rejection reaction to the absorbable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/00A61L17/14D01C3/00D06B13/00D06M16/00D06M15/15D06M11/74D06M11/48D06M15/03D06M101/12
CPCA61L17/00A61L17/005A61L17/10A61L17/14A61L2300/108A61L2300/236A61L2300/404A61L2300/412A61L2400/04D01C3/00D06B13/00D06M11/48D06M11/74D06M15/03D06M15/15D06M16/003D06M2101/12C08L89/00C08L5/08
Inventor 张硕张玉福李庆刚李静高宏宇彭丹王峰石新华牟秋红张方志
Owner NEW MATERIAL INST OF SHANDONG ACADEMY OF SCI
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