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Tumor microenvironment component marker combination and system for predicting nasopharyngeal carcinoma prognosis

A tumor microenvironment, nasopharyngeal cancer technology, applied in the biological field

Active Publication Date: 2020-11-10
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

[0003] There are many factors related to nasopharyngeal carcinoma, and there are many differentially expressed mRNAs. A large number of literatures have reported a variety of markers related to the prognosis of NPC. is a challenging job

Method used

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  • Tumor microenvironment component marker combination and system for predicting nasopharyngeal carcinoma prognosis
  • Tumor microenvironment component marker combination and system for predicting nasopharyngeal carcinoma prognosis
  • Tumor microenvironment component marker combination and system for predicting nasopharyngeal carcinoma prognosis

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Embodiment Construction

[0045] The inventors conducted research using single-cell mRNA sequencing technology and found that the tumor microenvironment of nasopharyngeal carcinoma contains five tumor cell components and 17 immune cell components, and through systematic bioinformatics calculations, the corresponding components of each component were mined. Signature genes, in nasopharyngeal carcinoma tumor tissue, by detecting the mRNA expression levels of the signature genes of each component, and performing single-sample gene enrichment analysis (ssGSEA) on the mRNA expression levels of the signature genes of each component , which can predict the expression level of each component in nasopharyngeal carcinoma tissue. Further, the inventors found six tumor microenvironment components that could predict the clinical prognosis of nasopharyngeal carcinoma patients by performing survival analysis on the expression levels of each component, including: cell cycle proliferation, macrophages, plasmacytoid dend...

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Abstract

The invention discloses a tumor microenvironment component marker combination and system for predicting nasopharyngeal carcinoma prognosis. The tumor microenvironment component marker combination comprises a cell cycle proliferation component and at least one of five immune cell components including macrophages, plasmacytoid dendritic cells, CLEC9A + dendritic cells, natural killer cells and plasma cells. According to some examples of the invention, the expression levels of different components in a nasopharyngeal carcinoma tumor microenvironment can be predicted by calculating the expressionlevels of respective feature genes of one tumor cell component and five immunocyte components, and clinical prognosis prediction can be performed on a nasopharyngeal carcinoma patient, so that individualized treatment is facilitated, and finally, survival benefits are brought to the patient.

Description

technical field [0001] The invention relates to the field of biology, in particular to a tumor microenvironment component marker combination and system for predicting the prognosis of nasopharyngeal carcinoma. Background technique [0002] Nasopharyngeal carcinoma is the most common head and neck tumor in China, especially in southern China, also known as "Guangdong tumor". According to different clinical stages, the current treatment methods for nasopharyngeal carcinoma are also different, mainly focusing on radiotherapy and chemotherapy, supplemented by targeted therapy, immunotherapy and other multidisciplinary comprehensive treatments. With the innovation of treatment methods and the implementation of standardized treatment, the survival rate and quality of life of patients with early nasopharyngeal carcinoma have been improved, but the prognosis of patients with advanced nasopharyngeal carcinoma is still poor, and patients with the same clinical stage will appear after ...

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G16B30/00G16H50/20
CPCC12Q1/6886G16B30/00G16H50/20C12Q2600/158C12Q2600/118
Inventor 马骏陈雨沛柳娜孙颖李文斐吕佳蔚王雅琴李晓敏李君炎张磐磐黎映琴唐玲珑毛燕萍周冠群何庆梅杨晓静
Owner SUN YAT SEN UNIV CANCER CENT
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